Abstract:In this report, polyvinyl alcohol/zinoxide (PVA/ZnO) & polyvinyl alcohol/titanium dioxide (PVA/TiO2) nanofibers were manufactured in three different concentrations of ZnO and TiO2 NPs for the application of self-cleaning properties because metallic oxides, specifically ZnO & TiO2, have the properties to remove the contaminants by hydroxyl radical (OH−1), which degrades the contaminants into small molecules and finally into CO2 and H2O. Therefore, these composites were manufactured by electrospinning. The resul… Show more
“…From the morphology study of nanofibers, it was obtained that GA did not have a significant effect on the morphology of nanofibers after cross-linking as presented in Fig. 2(b) and described in the previous literature 24 .Figure 2SEM of PVA/DSs nanofibers before crosslinking: ( a ) PVA/DSs nanofibers after crosslinking: ( b ) and cross-linked PVA/DSs after immersing in 0.5% w/w PAN/GENs: ( c ) 1% w/w PAN/GENs: ( d ) 2% w/w PAN/GENs: ( e ) 3% w/w PAN/GENs: ( f ) 4% w/w PAN/GENs: ( g ) and 5% w/w PAN/GENs: ( h ).…”
Section: Resultssupporting
confidence: 55%
“…The PVA spectrum in Fig. 5(C), showed a wild band at 3298 cm −1 response to the presence of OH functional group that the intensity of the same peak was decreased and shifted to higher wavelength due to a chemical reaction between PVA and GA after crosslinking 24 . Therefore, from the results, as summarized in Table 2, it was concluded that the method for crosslinking the PVA nanofibers did not have a significant effect on the structure of loaded DSs due to the presence of phenyl group at 841 and 1650 cm −1 .…”
Core-shell nanofibers with the ability to carry multiple drugs are attracting the attention to develop appropriate drug delivery systems for wounds dressing applications. In this study, biocompatible core-shell nanofibers have been designed as a promising dual-drug carrier with the capability of delivering both water-soluble and organic solvent-soluble drugs simultaneously. With the aim of fabricating the core-shell nanofibers, the dipping method has been employed. For this propose, core nanofibers made from polyvinyl alcohol (PVA) were immersed in various concentrations of polyacrylonitrile (PAN) and cross-linked by dipping into ethanol. Diclofenac sodium salt (DSs) and gentamicin sulfate (GENs) have been loaded into the core and shell nanofibers as models of the drug, respectively. The morphology study of core-shell nanofibers showed that the concentrations between 1% w/w up to 2% w/w PAN/GENs, with deep penetration into the internal layers of PAV/DSs nanofibers could lead to the core-shell structure. The cytotoxicity results showed the competency of designed core-shell nanofibers for wound dressing application. Also, the release profile exhibits the controllable behavior of drug release.
“…From the morphology study of nanofibers, it was obtained that GA did not have a significant effect on the morphology of nanofibers after cross-linking as presented in Fig. 2(b) and described in the previous literature 24 .Figure 2SEM of PVA/DSs nanofibers before crosslinking: ( a ) PVA/DSs nanofibers after crosslinking: ( b ) and cross-linked PVA/DSs after immersing in 0.5% w/w PAN/GENs: ( c ) 1% w/w PAN/GENs: ( d ) 2% w/w PAN/GENs: ( e ) 3% w/w PAN/GENs: ( f ) 4% w/w PAN/GENs: ( g ) and 5% w/w PAN/GENs: ( h ).…”
Section: Resultssupporting
confidence: 55%
“…The PVA spectrum in Fig. 5(C), showed a wild band at 3298 cm −1 response to the presence of OH functional group that the intensity of the same peak was decreased and shifted to higher wavelength due to a chemical reaction between PVA and GA after crosslinking 24 . Therefore, from the results, as summarized in Table 2, it was concluded that the method for crosslinking the PVA nanofibers did not have a significant effect on the structure of loaded DSs due to the presence of phenyl group at 841 and 1650 cm −1 .…”
Core-shell nanofibers with the ability to carry multiple drugs are attracting the attention to develop appropriate drug delivery systems for wounds dressing applications. In this study, biocompatible core-shell nanofibers have been designed as a promising dual-drug carrier with the capability of delivering both water-soluble and organic solvent-soluble drugs simultaneously. With the aim of fabricating the core-shell nanofibers, the dipping method has been employed. For this propose, core nanofibers made from polyvinyl alcohol (PVA) were immersed in various concentrations of polyacrylonitrile (PAN) and cross-linked by dipping into ethanol. Diclofenac sodium salt (DSs) and gentamicin sulfate (GENs) have been loaded into the core and shell nanofibers as models of the drug, respectively. The morphology study of core-shell nanofibers showed that the concentrations between 1% w/w up to 2% w/w PAN/GENs, with deep penetration into the internal layers of PAV/DSs nanofibers could lead to the core-shell structure. The cytotoxicity results showed the competency of designed core-shell nanofibers for wound dressing application. Also, the release profile exhibits the controllable behavior of drug release.
“…Natural and synthetic fibers have been electrospun either in single form or blends of different types of polymers to obtain desired features. 9,[33][34][35][36][37][38][39] Figure 1 briefly illustrates the process of electrospinning.…”
Background: Silver, incorporation with natural or synthetic polymers, has been used as an effective antibacterial agent since decades. Silver has potential applications in healthcare especially in nanoparticles form but silver sulfadiazine (AgSD) is the most efficient antibacterial agent especially for burn wound dressings. Method: In this report, mechanical, structural, and antibacterial properties of PAN nanofibers incorporation with silver sulfadiazine are mainly focused. AgSD was loaded for the first time on electrospinning as well as self-synthesized AgSD on PAN nanofibers by solution immersion method and then compared the results of both. Results: Occurrence of chemical reaction among the functional groups of AgSD and PAN were analyzed using FTIR, for both types of specimen. Morphological and surface properties of prepared nanofiber mats were characterized by scanning electron microscope, and it resulted in uniform nanofibers without bead formation. Diameter of nanofibers was slightly increased with addition of AgSD by in situ and immersion methods respectively. Nanoparticles distribution was analyzed by transmission electron microscopy. Thermal properties were analyzed by thermogravimetric analyzer and it was observed that AgSD decreased thermal stability of PAN which is better from biomedical perspective. X-ray diffraction declared crystalline structure of nanofiber mats. Presence of Ag and S contents in nanofiber mats was analyzed by X-ray photo spectroscopy. Antibacterial properties of nanofiber mats were investigated by disc diffusion method was carried out. E. coli and Bacillus bacteria strain were used as gram-negative and gram-positive respectively. Zone inhibition of the bacteria was used as a tool to determine effectiveness of AgSD released from PAN nanofiber mats. The antibacterial properties of PAN nanofibers impregnated with AgSD were determined with both types of bacteria strains to compare with control one. Conclusion: On the basis of characterization results it is concluded that PAN/AgSD (immersion) nanofiber mats have better structural and antibacterial properties than that of PAN/AgSD (in situ) nanofiber mats. So, from our point of view, self-synthesized AgSD is recommended for further production of nanofiber mats for antibacterial applications.
“…The enhancement in the resistance of bacterial strains has promoted the renewed interest in the development of new antibacterial approaches. One of them is the functionalizing the surface of the nanofiber's web with nanoparticles by facile method …”
The surface modification of nanofibers web enables the invention of wound dressings by using the simple materials substrate without altering the mechanical properties of foundation materials or nanofibers web. Herein, authors fabricated the novel antibacterial wound dressings by functionalizing the surface of cellulose acetate (CA) nanofibers. This surface treatment was done through facile method. The silver sulfadiazine (SSD) nanoparticles were successfully synthesized on the surface of cellulose acetate nanofibers web by in-situ facile method in which nanofibers webs were immersed in the solution of sodium sulfadiazine salt and silver nitrate (AgNO 3 ) for three different interval of times (hrs). The resultant CA/SSD nanofibers were characterized by scan electron microscope, transmission electron microscope, FT-IR, XPS, XRD, water contact angle and antibacterial agar disc diffusion test. All characterization results supported that this composite can be used for antibacterial wound dressings, especially for gram negative E. Coli bacteria because SSD has great potential against E. Coli bacteria.[a] Dr.
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