Self Emulsifying Drug Delivery System: A Recent Approach

Abstract

In recent years, nearly 40 % newer drugs compounds are hydrophobic in nature, which is a major challenge now-a-days for oral drug delivering due to low aqueous solubility. Lipid based drug delivery system is one of the favourable approach for poorly soluble compounds which can improve the drug absorption and oral bioavailability. Due to ion-pairing with appropriate surfactant and co-surfactant the macromolecular drug molecular oil droplet being found in the gut flow oral absorption which sufficiently stable towards lipase. Due to the formation of emulsified drug in micron level, it can efficiently endow the oral bioavailability. Several comprehensive papers have been published in the literature illustration diverse type of lipid based formulation with recent advancements. This article is based on an exhaustive and updated review on newer technology which out line an explicit discussion on its formulations and industrial scale up.

Formulation, In vitro and In vivo Evaluation of Sustained released Artemether-Lumefantrine-Loaded microstructured solid Lipid Microparticles (SLMs)

“…Increased surface area of the SLMs through globules formulation r the absorption of the drug molecule, led to enhanced intestinal permeability thus resulting in improved bioavailability and subsequent reduction in parasitemia. These findings in improved bioavailability collaborated the work of Bindhani et al 40 Literatures have shown that the bioavailability of artemetherlumefantrine increases with the administration of milk or fatty meals. 8 The formulation of artemether-lumefantrine in fatty microparticles could have improved its bioavailability as the solid lipid microparticles could have protected the entrapped artemetherlumefantrine from degradation.…”

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“…Medicines: A large number of herbal drugs and traditional medicines are being exploited and used for the development of SMEDDS because most of them have volatile and fixed oils 34,35 .…”

Preparation of self micro emulsifying drug delivery system(smedds) of poorly soluble drug eprosartan mesylate and its in vitro evaluation

“…Oral drug delivery is the most convenient and preferable route for administration of drugs because of low cost and easy administration (Bindhani et al, 2019). The oral route is the preferred route for chronic drug therapy.…”