Self‐fluorescent polymers for bioimaging

Ban, Qingfu; Li, Yan; Wu, Si

doi:10.1002/viw.20200135

Cited by 9 publications

(4 citation statements)

References 59 publications

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“…The compound HBT‐CHO was prepared according to the previous work 38,39 . The synthesis and the characterization of the compound (HBT‐CHO) is shown in Figure (S1).…”

Section: Methodsmentioning

confidence: 99%

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A new intramolecular proton transfer (ESIPT)‐based fluorescent probe for selective visualization of cyanide ion

Chen

Zhang

Wen

et al. 2022

VIEW

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Fluorescent probes for detection of CN − still have many limitations, such as small Stokes shift, irreversible, and background interference, which hamper their applications for on-site detection and bioimaging of CN − . In this work, we design a new CN − -activatable fluorescent probe (named AHMM) containing an ESIPT (excited-state intramolecular proton transfer) and hydrogen bond features, which show a large Stokes shift (225 nm) and molecular structural reversible detection. The probe AHMM exhibits an excellent selectivity for CN − without any interference from other anions in aqueous DMSO system. Furthermore, the mechanism of the interaction of AHMM with CN − is concluded by various experiments. The limit of detection of AHMM for CN − is calculated as low as 4.47 × 10 −8 M, lower than the concentration of CN − deemed acceptable by WHO (World Health Organization). AHMM can recognize CN − in tap water quantitatively and on-site by a smartphone APP. Moreover, food samples such as almond and cassava including CN − are visualized by fluorescence imaging. In addition, the probe shows practical applications of CN − imaging in cells and mice. This concept can be applied for designing multifunctional fluorescent probes with ESIPT and reversible characteristics for detection of CN − .

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“…The compound HBT‐CHO was prepared according to the previous work 38,39 . The synthesis and the characterization of the compound (HBT‐CHO) is shown in Figure (S1).…”

Section: Methodsmentioning

confidence: 99%

“…The compound HBT-CHO was prepared according to the previous work. 38,39 The synthesis and the characterization of the compound (HBT-CHO) is shown in Figure (S1). The compound HBT-CHO (1 mmol, 0.269 g) and diaminomaleonitrile A (1.5 mmol, 0.162 g) were added to 40 ml dry EtOH, then the mixture was reacted at 50 S4).…”

Section: Synthesis Of Hbt-cho and Ahmmmentioning

confidence: 99%

A new intramolecular proton transfer (ESIPT)‐based fluorescent probe for selective visualization of cyanide ion

Chen

Zhang

Wen

et al. 2022

VIEW

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“…[85,[116][117][118][119] and chitosan (CS). [87,[120][121][122] PAMAM is a class of synthetic polymers with hyperbranched structure and high-density surface functional groups. In order to ensure the effective combination of Cas9 RNP and PAMAM, some researchers used high-density phenylboric acid to functionalize the surface of PAMAM.…”

Section: Cationic Polymersmentioning

confidence: 99%

Nanoplatform‐Based In Vivo Gene Delivery Systems for Cancer Therapy

Luo,

Le,

et al. 2024

Small

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Gene therapy uses modern molecular biology methods to repair disease‐causing genes. As a burgeoning therapeutic, it has been widely applied for cancer therapy. Since 1989, there have been numerous clinical gene therapy cases worldwide. However, a few are successful. The main challenge of clinical gene therapy is the lack of efficient and safe vectors. Although viral vectors show high transfection efficiency, their application is still limited by immune rejection and packaging capacity. Therefore, the development of non‐viral vectors is overwhelming. Nanoplatform‐based non‐viral vectors become a hotspot in gene therapy. The reasons are mainly as follows. 1) Non‐viral vectors can be engineered to be uptaken by specific types of cells or tissues, providing effective targeting capability. 2) Non‐viral vectors can protect goods that need to be delivered from degradation. 3) Nanoparticles can transport large‐sized cargo such as CRISPR/Cas9 plasmids and nucleoprotein complexes. 4) Nanoparticles are highly biosafe, and they are not mutagenic in themselves compared to viral vectors. 5) Nanoparticles are easy to scale preparation, which is conducive to clinical conversion and application. Here, an overview of the categories of nanoplatform‐based non‐viral gene vectors, the limitations on their development, and their applications in cancer therapy.

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“…Various classes of fluorescent materials such as small-molecule organic dyes [ 18 , 19 , 20 , 21 ], fluorescent proteins [ 22 , 23 , 24 ], self-fluorescent polymers [ 10 , 25 , 26 , 27 ], dye-labeled polymeric nanoparticles [ 28 , 29 , 30 , 31 , 32 , 33 , 34 ], and quantum dots [ 35 , 36 , 37 , 38 ] have been explored. Among these, fluorescent dyes have gained popularity due to their commercial availability, ease of operation, and high resolution [ 39 ].…”

Section: Introductionmentioning

confidence: 99%

Highly Sensitive Detection of Bacteria by Binder-Coupled Multifunctional Polymeric Dyes

Kapil

Lee

et al. 2023

Polymers

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Infectious diseases caused by pathogens are a health burden, but traditional pathogen identification methods are complex and time-consuming. In this work, we have developed well-defined, multifunctional copolymers with rhodamine B dye synthesized by atom transfer radical polymerization (ATRP) using fully oxygen-tolerant photoredox/copper dual catalysis. ATRP enabled the efficient synthesis of copolymers with multiple fluorescent dyes from a biotin-functionalized initiator. Biotinylated dye copolymers were conjugated to antibody (Ab) or cell-wall binding domain (CBD), resulting in a highly fluorescent polymeric dye-binder complex. We showed that the unique combination of multifunctional polymeric dyes and strain-specific Ab or CBD exhibited both enhanced fluorescence and target selectivity for bioimaging of Staphylococcus aureus by flow cytometry and confocal microscopy. The ATRP-derived polymeric dyes have the potential as biosensors for the detection of target DNA, protein, or bacteria, as well as bioimaging.

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Self‐fluorescent polymers for bioimaging

Cited by 9 publications

References 59 publications

A new intramolecular proton transfer (ESIPT)‐based fluorescent probe for selective visualization of cyanide ion

A new intramolecular proton transfer (ESIPT)‐based fluorescent probe for selective visualization of cyanide ion

Nanoplatform‐Based In Vivo Gene Delivery Systems for Cancer Therapy

Highly Sensitive Detection of Bacteria by Binder-Coupled Multifunctional Polymeric Dyes

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