Self-Folding of Three-Dimensional Hydrogel Microstructures

Guan, Jingjiao; He, Hongyan; Hansford, Derek J.; Lee, L. James

doi:10.1021/jp054341g

Cited by 176 publications

(158 citation statements)

References 9 publications

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“…[6] This renders them an ideal base material for tuning internal stresses, as spatially segregating the degree of swelling in different regions of the hydrogel generates such stresses in a precise and controllable manner. [7] Gracias and co-workers have utilized this principle of patterned differential swelling to drive self-folding of poly (ethylene glycol) (PEG)-based hydrogel bilayers. [8] Their approach, relying on conventional photolithography to pattern PEG-based hydrogels, has broad applicability toward the manufacturing of microscale and macroscale 3D geometries.…”

Section: Self-assembly Of Bioinspired Materialsmentioning

confidence: 99%

Biomimicry, Biofabrication, and Biohybrid Systems: The Emergence and Evolution of Biological Design

Raman

Bashir

2017

Adv Healthcare Materials

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how the concept of bioinspiration, or imitating biological design and functionality in synthetic materials, created a new class of "smart" biomimetic materials. Then, we shall discuss how the continuing development of enabling manufacturing technologies, such as 3D printing and microfluidics, has established the separate subdiscipline of biofabrication for tissue engineering, or "building with biology." Finally, we shall investigate the convergence of these two fields into the emerging discipline of biohybrid design, the use of biological materials to power non-natural functional behaviors in synthetic machines. Throughout this report, we will revisit a single class of materials, hydrogels, as a case study of biological design in the context of each subfield, and discuss how the constraints, underlying principles, and end-use applications differ in each case. We will also discuss ethical considerations of biological design, with a special focus on forward engineering non-natural or hypernatural functional behaviors in biohybrid systems. We will conclude with recommendations for implementing biological design into educational curricula, ensuring effective and responsible practices for the next generation of engineers and scientists. Biomimicry and Bioinspired DesignA deeper understanding of the underlying design principles that govern biological systems has inspired the field of biomimicry. [1,2] Observing adaptive phenomena in nature, scientists and engineers have sought to extract the components of biological design responsible for this behavior and replicate the behavior in synthetic materials. Fundamentally, this involves understanding the building blocks or base units from which a biological material is built, the hierarchical assembly of these building blocks, and the interactions and interfaces between them.In this section, we will discuss strategies that engineers and scientists have employed to engineer bioinspired hierarchy, from bottom-up self-assembly and top-down engineered assembly. We will present several key demonstrations of stimulus-responsive hydrogels ranging from the micro-to the macroscale, and investigate novel demonstrations in biomimetic actuation and movement. We will conclude with the remaining challenges in the field of biomimicry and discuss the potential future impact of bioinspired design.The discipline of biological design has a relatively short history, but has undergone very rapid expansion and development over that time. This Progress Report outlines the evolution of this field from biomimicry to biofabrication to biohybrid systems' design, showcasing how each subfield incorporates bioinspired dynamic adaptation into engineered systems. Ethical implications of biological design are discussed, with an emphasis on establishing responsible practices for engineering non-natural or hypernatural functional behaviors in biohybrid systems. This report concludes with recommendations for implementing biological design into educational curricula, ensuring effective and responsible practice...

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Section: Self-assembly Of Bioinspired Materialsmentioning

confidence: 99%

Biomimicry, Biofabrication, and Biohybrid Systems: The Emergence and Evolution of Biological Design

Raman

Bashir

2017

Adv Healthcare Materials

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“…These mechanisms can be patterned templates or thin films which can be folded, curved, or rolled-up to become spirals, tubes, and cylindrical tubes [73,74]. Selffolding can occur spontaneously or in response to stimuli such as light, pH [75], temperature, magnetic field, or solvent [76,77]. In Figure 6, self-folding mechanism which is provided by hinges is shown briefly.…”

Section: Self-folding Polymersmentioning

confidence: 99%

Smart Delivery Systems with Shape Memory and Self-Folding Polymers

Erkeçoğlu¹,

Sezer²,

Bucak³

2016

Smart Drug Delivery System

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New generation delivery systems involve smart materials such as shape memory and self-folding polymers. Shape memory polymers revert back to their original shape above their glass transition temperatures where this temperature change can be induced conventionally, photolytically, with a lazer or magnetically depending on the composition of the material. This ability to assume original shape upon a trigger can be used in delivering drugs, DNA or cells. Self folding polymers are a new class of materials which may be composed of multilayers with different thermal expansion coefficients or with hinges that allow folding upon being triggered. These new materials allow various architectural designs of smart delivery vehicles predominantly for DNA and cells. The aim of this chapter is given shape and folding polymers and their usage for drug delivery systems.

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“…There are a diverse range of self-folding techniques that have already been demonstrated 21 . These methods utilize heat [22][23][24][25] , magnetic fields 26,27 , electric fields 28 , or liquid 29,30 to trigger folding along hinges. However, each has one or more limitations.…”

Section: Introductionmentioning

confidence: 99%

Self-folding with shape memory composites

et al. 2013

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Origami-inspired manufacturing can produce complex structures and machines by folding two-dimensional composites into three-dimensional structures. This fabrication technique is potentially less expensive, faster, and easier to transport than more traditional machining methods, including 3-D printing. Self-folding enhances this method by minimizing the manual labor involved in folding, allowing for complex geometries and enabling remote or automated assembly. This paper demonstrates a novel method of self-folding hinges using shape memory polymers (SMPs), paper, and resistive circuits to achieve localized and individually addressable folding at low cost. A model for the torque exerted by these composites was developed and validated against experimental data, in order to determine design rules for selecting materials and designing hinges. Torque was shown to increase with SMP thickness, resistive circuit width, and supplied electrical current. This technique was shown to be capable of complex geometries, as well as locking assemblies with sequential folds. Its functionality and low cost make it an ideal basis for a new type of printable manufacturing based on two-dimensional fabrication techniques.

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Self-Folding of Three-Dimensional Hydrogel Microstructures

Cited by 176 publications

References 9 publications

Biomimicry, Biofabrication, and Biohybrid Systems: The Emergence and Evolution of Biological Design

Biomimicry, Biofabrication, and Biohybrid Systems: The Emergence and Evolution of Biological Design

Smart Delivery Systems with Shape Memory and Self-Folding Polymers

Self-folding with shape memory composites

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