Self‐gated, dynamic contrast‐enhanced magnetic resonance imaging with compressed‐sensing reconstruction for evaluating endothelial permeability in the aortic root of atherosclerotic mice

Calcagno, Claudia; David, J. W.; Motaal, Abdallah G.; Coolen, Bram F.; Beldman, Thijs J.; Corbin, Alexandra; Kak, Arnav; Ramachandran, Sarayu; Pruzan, Alison; Sridhar, Arthi; Soler, Raphaël; Faries, Christopher; Fayad, Zahi A.; Mulder, Willem J. M.; Strijkers, Gustav J.

doi:10.1002/nbm.4823

Cited by 3 publications

(1 citation statement)

References 42 publications

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“…Unfortunately, the centrality of all the authors was less than 0.1, suggesting that even though lots of scholars were involved in this area, they were relatively dispersal. It is worth noting that Fayad, ZA and his team’s current research is in the development and use of CMR ( Calcagno et al, 2023 ) and fast computed tomography (CT) to characterize the elements leading to atherosclerotic plaque rupture ( Achenbach et al, 2022 ; Senders et al, 2022 ) and the definition of the components of plaque most active in initiating thrombosis ( Senders et al, 2018 ). Meanwhile, as for the co-cited authors’ analysis, LIBBY P from Harvard Medical School and Brigham and Women’s Hospital ranked first with a citation frequency of 493, and he is a cardiologist committed to clinical and basal research focus on the role of inflammation in vascular diseases such as atherosclerosis, and he has published large numbers of papers from 1995 up to the present ( Libby and Everett, 2019 ; Ridker et al, 2021 ; Stone et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Molecular imaging research in atherosclerosis: A 23-year scientometric and visual analysis

Pan

Chen

et al. 2023

Front. Bioeng. Biotechnol.

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Background: Cardiovascular and cerebrovascular diseases are major global health problems, and the main cause is atherosclerosis. Recently, molecular imaging has been widely employed in the diagnosis and therapeutic applications of a variety of diseases, including atherosclerosis. Substantive facts have announced that molecular imaging has broad prospects in the early diagnosis and targeted treatment of atherosclerosis.Objective: We conducted a scientometric analysis of the scientific publications over the past 23 years on molecular imaging research in atherosclerosis, so as to identify the key progress, hotspots, and emerging trends.Methods: Original research and reviews regarding molecular imaging in atherosclerosis were retrieved from the Web of Science Core Collection database. Microsoft Excel 2021 was used to analyze the main findings. CiteSpace, VOSviewer, and a scientometric online platform were used to perform visualization analysis of the co-citation of journals and references, co-occurrence of keywords, and collaboration between countries/regions, institutions, and authors.Results: A total of 1755 publications were finally included, which were published by 795 authors in 443 institutions from 59 countries/regions. The United States was the top country in terms of the number and centrality of publications in this domain, with 810 papers and a centrality of 0.38, and Harvard University published the largest number of articles (182). Fayad, ZA was the most productive author, with 73 papers, while LIBBY P had the most co-citations (493). CIRCULATION was the top co-cited journal with a frequency of 1,411, followed by ARTERIOSCL THROM VAS (1,128). The co-citation references analysis identified eight clusters with a well-structured network (Q = 0.6439) and highly convincing clustering (S = 0.8865). All the studies calculated by keyword co-occurrence were divided into five clusters: “nanoparticle,” “magnetic resonance imaging,” “inflammation,” “positron emission tomography,” and “ultrasonography”. Hot topics mainly focused on cardiovascular disease, contrast media, macrophage, vulnerable plaque, and microbubbles. Sodium fluoride ⁃PET, targeted drug delivery, OCT, photoacoustic imaging, ROS, and oxidative stress were identified as the potential trends.Conclusion: Molecular imaging research in atherosclerosis has attracted extensive attention in academia, while the challenges of clinical transformation faced in this field have been described in this review. The findings of the present research can inform funding agencies and researchers toward future directions.

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Section: Discussionmentioning

confidence: 99%

Molecular imaging research in atherosclerosis: A 23-year scientometric and visual analysis

Pan

Chen

et al. 2023

Front. Bioeng. Biotechnol.

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Self‐gated, dynamic contrast‐enhanced magnetic resonance imaging with compressed‐sensing reconstruction for evaluating endothelial permeability in the aortic root of atherosclerotic mice

et al. 2022

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High-risk atherosclerotic plaques are characterized by active inflammation and abundant leaky microvessels. We present a self-gated, dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) acquisition with compressed sensing reconstruction and apply it to assess longitudinal changes in endothelial permeability in the aortic root of Apoe À/À atherosclerotic mice during natural disease progression.Twenty-four, 8-week-old, female Apoe À/À mice were divided into four groups (n = 6 each) and imaged with self-gated DCE-MRI at 4, 8, 12, and 16 weeks after highfat diet initiation, and then euthanized for CD68 immunohistochemistry for macrophages. Eight additional mice were kept on a high-fat diet and imaged longitudinally at the same time points. Aortic-root pseudo-concentration curves were analyzed using a validated piecewise linear model. Contrast agent wash-in and washout slopes

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Evaluating Atherosclerotic Plaque Composition Using 3D Magnetic Resonance Imaging

Salagrama,

Bhardwaj,

Logeshwaran

et al. 2023

2023 International Conference on Emerging Research in Computational Science (ICERCS)

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Self‐gated, dynamic contrast‐enhanced magnetic resonance imaging with compressed‐sensing reconstruction for evaluating endothelial permeability in the aortic root of atherosclerotic mice

Cited by 3 publications

References 42 publications

Molecular imaging research in atherosclerosis: A 23-year scientometric and visual analysis

Molecular imaging research in atherosclerosis: A 23-year scientometric and visual analysis

Self‐gated, dynamic contrast‐enhanced magnetic resonance imaging with compressed‐sensing reconstruction for evaluating endothelial permeability in the aortic root of atherosclerotic mice

Evaluating Atherosclerotic Plaque Composition Using 3D Magnetic Resonance Imaging

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