Self-healing gelatin-based shape memory hydrogels via quadruple hydrogen bonding and coordination crosslinking for controlled delivery of 5-fluorouracil

Xu, Yuande; Hong, Yang; Zhu, Heyan; Jiang, Long; Yang, Hua

doi:10.1080/09205063.2020.1713711

Cited by 17 publications

(13 citation statements)

References 30 publications

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“…Gelatin based self-healing hydrogels were explored for the delivery of 5-fluorouracil (5-FU) for cancer therapy. The self-healing mechanism is attributed to the reversible dimerization of ureidopyrimidinone (UPy) side chains present in gelatin (Gelatin-UPy) as well as through the coordination crosslinking by introducing Fe 3+ in gelatin-UPy hydrogels [135]. An injectable self-healing hydrogel was made using Gum Arabic (GA) and Chitosan (CS) for the controlled release of nano curcumin as an anti-cancer treatment.…”

Section: Natural Polymer Based Self-healing Hydrogels As Drug Delivery Platforms For Cancer Therapymentioning

confidence: 99%

Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications

Shyam

Palaniappan

et al. 2021

Polymers

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Polymeric hydrogels are widely explored materials for biomedical applications. However, they have inherent limitations like poor resistance to stimuli and low mechanical strength. This drawback of hydrogels gave rise to ‘‘smart self-healing hydrogels’’ which autonomously repair themselves when ruptured or traumatized. It is superior in terms of durability and stability due to its capacity to reform its shape, injectability, and stretchability thereby regaining back the original mechanical property. This review focuses on various self-healing mechanisms (covalent and non-covalent interactions) of these hydrogels, methods used to evaluate their self-healing properties, and their applications in wound healing, drug delivery, cell encapsulation, and tissue engineering systems. Furthermore, composite materials are used to enhance the hydrogel’s mechanical properties. Hence, findings of research with various composite materials are briefly discussed in order to emphasize the healing capacity of such hydrogels. Additionally, various methods to evaluate the self-healing properties of hydrogels and their recent advancements towards 3D bioprinting are also reviewed. The review is concluded by proposing several pertinent challenges encountered at present as well as some prominent future perspectives.

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Section: Natural Polymer Based Self-healing Hydrogels As Drug Delivery Platforms For Cancer Therapymentioning

confidence: 99%

Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications

Shyam

Palaniappan

et al. 2021

Polymers

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“…However, the mechanical properties of such gels are usually not satisfactory; thus, the proteins should be additionally chemically cross-linked or mixed with synthetic polymers. The ionization of amino acids depends on acidity/alkalinity of the environment, which is why the proteins are the most commonly used for pH-sensitive hydrogels’ preparation [ 10 , 11 , 19 , 20 , 21 , 22 , 23 ]. Another group of biopolymers that may create hydrogels stabilized by hydrogen bonds is polysaccharides (e.g., hyaluronic acid (HA), chitosan (CS), starch, agar) and their derivatives (e.g., carboxymethylcellulose, hydroxypropyl chitosan).…”

Section: Interactions In Supramolecular Hydrogelsmentioning

confidence: 99%

From Supramolecular Hydrogels to Multifunctional Carriers for Biologically Active Substances

Skopińska-Wiśniewska

Flor

Kozłowska

2021

IJMS

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Supramolecular hydrogels are 3D, elastic, water-swelled materials that are held together by reversible, non-covalent interactions, such as hydrogen bonds, hydrophobic, ionic, host–guest interactions, and metal–ligand coordination. These interactions determine the hydrogels’ unique properties: mechanical strength; stretchability; injectability; ability to self-heal; shear-thinning; and sensitivity to stimuli, e.g., pH, temperature, the presence of ions, and other chemical substances. For this reason, supramolecular hydrogels have attracted considerable attention as carriers for active substance delivery systems. In this paper, we focused on the various types of non-covalent interactions. The hydrogen bonds, hydrophobic, ionic, coordination, and host–guest interactions between hydrogel components have been described. We also provided an overview of the recent studies on supramolecular hydrogel applications, such as cancer therapy, anti-inflammatory gels, antimicrobial activity, controlled gene drug delivery, and tissue engineering.

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“…With the idea of broadening the range of available multifunctional materials -i.e. polymers showing different independent functionalities -and to tailor them to the desired application, new polymers were purposely synthetized [64,72,[74][75][76]79,[113][114][115][116][117][118][119][120].…”

Section: Ddss Based On Smmsmentioning

confidence: 99%

Shape memory materials and 4D printing in pharmaceutics

Melocchi

Uboldi

Cerea

et al. 2021

Advanced Drug Delivery Reviews

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Self-healing gelatin-based shape memory hydrogels via quadruple hydrogen bonding and coordination crosslinking for controlled delivery of 5-fluorouracil

Cited by 17 publications

References 30 publications

Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications

Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications

From Supramolecular Hydrogels to Multifunctional Carriers for Biologically Active Substances

Shape memory materials and 4D printing in pharmaceutics

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