Self-healing polymer design from dynamic B–O bonds to their emerging applications

Zheng, Jie; Oh, Xin Yi; Ye, Enyi; Chooi, Wai Hon; Zhu, Qiang; Loh, Xian Jun; Liu, Yupeng

doi:10.1039/d2qm01128j

Cited by 17 publications

(10 citation statements)

References 132 publications

(241 reference statements)

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“…Moreover, hydrogels are able to actively interact with the surrounding environment due to the presence of abundant functional groups in their polymeric networks and can be endowed with injectability and self-healing ability through a rational design. [24,25] F I G U R E 2 Evolutionary trend of different types of wound dressings.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, hydrogel frameworks are gas permeable, making it possible for the wound tissues to “breathe”. Moreover, hydrogels are able to actively interact with the surrounding environment due to the presence of abundant functional groups in their polymeric networks and can be endowed with injectability and self‐healing ability through a rational design [24,25] …”

Section: Introductionmentioning

confidence: 99%

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Responsive hydrogel dressings for intelligent wound management

Wang

Yeo

et al. 2023

BMEMat

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Due to global aging problems, the rising number of patients suffering from chronic or hard‐to‐heal acute wounds imposes a significant burden on healthcare systems. Wound healing is a complicated and dynamic physiological process with distinct molecular and cellular levels at each phase. Despite numerous strategies and advanced wound dressings being developed, successful wound management through smart dressing materials that can adapt to changing wound microenvironments and address the needs of wounds at different stages remains a big challenge. Over the last decade, hydrogel‐based dressings have emerged as one of the most potent biomaterials for wound treatment with favorable biological characteristics and a high potential for active intervention during the wound‐curing process. In the current contribution, we present the most recent progress in smart hydrogel dressings that can regulate the release of therapeutics in response to external stimuli (such as light) as well as endogenous changes in wound environments (e.g., temperature, pH, glucose, and reactive oxygen species) to facilitate wound healing. We also introduce the cutting‐edge technologies of intelligent “sense‐and‐treat” dressings through a combination of built‐in sensors or sensing molecules with responsive hydrogels, which enable real‐time monitoring of wound conditions and prompt on‐demand therapy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Responsive hydrogel dressings for intelligent wound management

Wang

Yeo

et al. 2023

BMEMat

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“…Materials. The thermoplastic polyether based polyurethane (TPU) Elastollan 1185 A 15 000 with a density of 1.12 g/cm 3 was supplied in granular form by BASF Polyurethanes India Ltd. Germany. Epoxidized natural rubber with 50% epoxidation (ENR 50) with a Mooney viscosity (ML (1+4) 100 °C) of 80.3 was supplied by Muang Mai Guthrie public company limited, Thailand.…”

Section: Methodsmentioning

confidence: 99%

“…Self-healing materials, which can rebuild their structural integrity from possible physical damage and failure have received much attention in the current environmental challenge, where there is a significant need to improve the sustainability and durability of products. − Recently, research on self-healing materials has been very active to explore their potential applications in the fields of artificial muscles, wearable electronic devices, intelligent actuators, medical implants, etc. − However, most of the self-healing materials require external energy for the healing process, and the resulting materials show low mechanical strength. Among the various self-healing materials currently being developed, the self-healing polymers are the most versatile and unique material. − At present, the development of innovative supramolecular networks is the most efficient approach to introduce self-healing functionality in the polymeric materials. , One can develop such type of supramolecular networks in polymers by creating reversible covalent-bonds, such as Diels–Alder bonds and amine based bonds, and reversible noncovalent-bonds, such as hydrogen bonds, coordination bonds, and ionic bonds, which can generate reversible association–dissociation behavior triggered by an external stimulus, thereby initiating and enabling the damage–repair process. ,− However, the closure of the crack is a prerequisite for the self-healing process, which can only be achieved by contacting the damaged surfaces using external forces and is challenging to execute practically.…”

Section: Introductionmentioning

confidence: 99%

Shape Memory Behavior and Self-Healing Effects of Dynamically Vulcanized TPU/ENR Thermoplastic Elastomeric Blends

Banerjee

2023

ACS Appl. Polym. Mater.

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In this work, an innovative TPE material architecture with excellent shape memory and self-healing properties has been fabricated by introducing an in situ polymerized zinc dimethacrylate (PZDMA) onto the macromolecular chains of thermoplastic polyurethane (TPU) and epoxidized natural rubber (ENR) via dynamic vulcanization. Damage to the developed material surface could be healed by physical contact between the cut surfaces through a contraction force (i.e., shape memory effect), reassociation of ionic networks, and molecular diffusion of ENR chains at the interface. Interestingly, PZDMA not only promotes the shape memoryassisted self-healing functionality by enhancing ionic interactions with the blend components but also improves mechanical properties by the formation of ionic clusters which act as a reinforcement. The formation of such ionic reversible networks and clusters was evident from temperature dependent Fourier transform infrared spectroscopy, X-ray diffraction, Small angle X-ray scattering, X-ray photon spectroscopy, and transmission electron microscopy studies. The resulting material exhibited excellent shape-fixation ratio (R f ∼ 95%), shape-recovery ratio (R r ∼ 98%), healing efficiency (∼80% based on tensile strength of pristine sample and healed sample) and oil swelling resistance (5−6% in ASTM oil #3) at a suitable transition temperature of 80 °C. This work provides a promising route for the fabrication of next generation TPE materials, which may also be developed into innovative programmable elastomeric materials.

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“…Recently, reversible covalent bonds such as imine bonds, acylhydrazone bonds, disulfide bonds, and B–O bonds have been frequently utilized as dynamic cross-linkers to fabricate self-healable and recyclable polyurethane elastomers. ,, In comparison to noncovalent interactions, these reversible covalent bonds usually possess higher binding energy. Therefore, introducing high-density reversible covalent bonds into the polymer networks of polyurethane elastomers will realize the development of high-performance polyurethane elastomers with good self-healable efficiency.…”

Section: Introductionmentioning

confidence: 99%

Mechanically Robust yet Body-Temperature Self-Healable Polyurethane Elastomer via the Cross-Linking of Dynamic Boroxines

Bao,

Miao,

Yin

et al. 2023

ACS Appl. Polym. Mater.

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It has been a long-standing goal to develop self-healable polyurethane elastomers with desirable mechanical strength and toughness to satisfy the needs of practical applications. However, the conflict between mechanical strength and self-healing efficiency makes the development of such materials very challenging. Here, we have developed a mechanically robust and body-temperature self-healable polyurethane elastomer via the synergy of multiple dynamic reversible non-and covalent interactions in the polymer networks. The design selects flexible 1,4-butanediol bis(3-aminopropyl) ether (BBE) as the chain extender to endow the elastomer with toughness and chain flexibility to benefit its self-healing at body temperature. In addition, 4-formylphenylboronic acid (4-FPBA) was used to cross-link the polyurethane prepolymer to enhance the mechanical properties by the dehydration of phenylboronic acids. Therefore, the asprepared boroxine cross-linked poly(urethane-urea) (PUUI-Boroxine) elastomer exhibited high mechanical strength and toughness of ∼49.2 MPa and ∼162.9 MJ m −3 , respectively. Importantly, the damaged PUUI-Boroxine elastomer can be healed with a high healing efficiency of 91% at 37 °C for 15 h. The PUUI-Boroxine elastomer can also be solution reprocessed for at least three cycles with only a minimal decline in its mechanical properties. Finally, the PUUI-Boroxine elastomer can be employed to fabricate a body-temperature self-healable watchband. This work provides a facile strategy for the development of body-temperature self-healable polyurethane elastomers with outstanding mechanical strength and toughness.

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Self-healing polymer design from dynamic B–O bonds to their emerging applications

Abstract: Robust healable and reprocessable polymers have attracted increasing attention as a viable alternative to thermosets for increasing material service life and reducing plastic-related wastes. Recently, reversible covalent adaptable bonds have...

Cited by 17 publications

References 132 publications

Responsive hydrogel dressings for intelligent wound management

Responsive hydrogel dressings for intelligent wound management

Shape Memory Behavior and Self-Healing Effects of Dynamically Vulcanized TPU/ENR Thermoplastic Elastomeric Blends

Mechanically Robust yet Body-Temperature Self-Healable Polyurethane Elastomer via the Cross-Linking of Dynamic Boroxines

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