A survey was conducted online from December 30, 2020 to January 21, 2021, among the population of Lubumbashi city, to assess Knowledge, Attitudes and Practices (KAP) towards COVID-19. The resource persons were self-selected at random, to have freely accepted to answer the online questionnaire. A total of 487 people (50.7% of women), with an average age of 28.3 ± 7.7 years, were interviewed. Overall, 98.2% said they were aware of COVID-19. This knowledge comes from several sources dominated by television (42.7%). Several respondents (71.9%) admitted to being afraid of human-to-human transmission of COVID-19; while 72.1% hope that this disease will stop one day. Protective practices against COVID-19 contamination are dominated by wearing a surgical mask, social distancing and hand washing (66.9%). Self-medication either with medicinal plants or with conventional drugs are the most recommended practices by the questioned people, in case of symptoms related to COVID-19 (70.6%). Most medicinal plants [predominated by Eucalyptus globulus Labill. (45.9%, n = 344)] and conventional drugs [predominantly aspirin (41.5%; n = 41)], cited in this case, are reported in various studies as being used in the management of patients with COVID-19. In general, the KAPs observed vary considerably according to the gender and study level of the questioned people. The level of knowledge about COVID-19 among the population of Lubumbashi seems satisfactory and its management acceptable. Practices to control the COVID-19 symptom are predominated by the use of both conventional and non-conventional medicine. However, sensitization of the population of Lubumbashi for a better knowledge and adequate management of this virus is desirable.