Self Nano Emulsifying Drug Delivery System: A Novel Technique for Enhancement of Oral Bioavailability

Arun, Jagdish K; Rajeshwar, V.; Shrivastava, Birendra; Bakshi, Vasudha

doi:10.5958/0974-360x.2020.00448.5

Cited by 6 publications

(1 citation statement)

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“…Generally, the conventional liquid SMEDDS (L-SMEDDS) are encapsulated in hard or soft gelatin capsules. However, the lipid technique may also interact with the capsules, ensuing both hardness and softness of the shell 9,10,11,12 . L-SMEDDS promotes drug absorption via intestinal lymph by passing the firstpass impact of drugs.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2022

IJPSR

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SMEDDS are formulated to improve the oral bioavailability of lipophilic drugs. It is an isotropic mixture of compounds like oil, surfactant, co-surfactant, and drug having the unique ability to form fine o/w micro-emulsion by agitation and diluted with GI fluid. Its liquid formulation technique enhanced the absorption and bioavailability of poorly watersoluble drugs but also had a few drawbacks like long time period stability issues and storage conditions. Some special techniques convert the liquid form into solid dosage form to overcome these problems. The present paper gives exhaustive information about formulation design by screening excipients. We study the selection and solubility of excipients, its preparation and characterization, and the mechanism by which bioavailability can be improved. This discussion is useful for a better understanding of SMEDDS for its recent advancements, marketed formulation, and patents on SMEDDS. The poorly water-soluble drugs having dissolution rate absorption limited can be effectively formulated in the form of SMEDDS causing a stable plasma profile. The plasma levels of the poorly aqueous soluble medicament show the critical passage of drug absorption, i.e., dissolution. Surfactants with a high HLB value, such as Tween 80 are said to increase the permeability of active ingredients when administered in conjunction with the formulation due to their loosening effect on tight junctions.

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Section: Introductionmentioning

confidence: 99%

Untitled

2022

IJPSR

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Micro and nanoemulsion as drug carriers in Alzheimer's disease

Patel,

Paliwal,

Sawant

et al. 2024

Alzheimer's Disease and Advanced Drug Delivery Strategies

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Functional Excipients and Novel Drug Delivery Scenario in Self-nanoemulsifying Drug Delivery System: A Critical Note

Singh

Tonjan

2022

PNT

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Lipid-based formulations have emerged as prospective dosage forms for extracting the therapeutic effects of existing lipophilic compounds and novel chemical entities more efficiently. Compared to other excipients, lipids have the added benefit of enhancing the bioavailability of lipophilic and highly metabolizable drugs due to their unique physicochemical features and similarities to in vivo components. Furthermore, lipids can minimize the needed dose and even the toxicity of drugs with poor aqueous solubility when employed as the primary excipient. Hence, the aim of the present review is to highlight the functional behavior of lipid excipients used in SNEDD formulation along with the stability aspects of the formulation in vivo. Moreover, this review also covered the importance of SNEDDS in drug delivery, the therapeutic and manufacturing benefits of lipids as excipients, and the technological advances made so far to convert liquid to solid SNEDDS like melt granulation, adsorption on solid support, spray cooling, melt extrusion/ spheronization has also highlighted. The mechanistic understanding of SNEDD absorption in vivo is highly complex, which was discussed very critically in this review. An emphasis on their application and success on an industrial scale was presented, as supported by case studies and patent surveys.

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Self Nano Emulsifying Drug Delivery System: A Novel Technique for Enhancement of Oral Bioavailability

Cited by 6 publications

References 0 publications

Untitled

Untitled

Micro and nanoemulsion as drug carriers in Alzheimer's disease

Functional Excipients and Novel Drug Delivery Scenario in Self-nanoemulsifying Drug Delivery System: A Critical Note

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