Self-plasticized, lumogallion-based fluorescent optical sensor for the determination of aluminium (III) with ultra-low detection limits

Mendecki, Lukasz; Granados-Fócil, Sergio; Jendrlin, Martin; Mold, Matthew; Radu, Aleksandar

doi:10.1016/j.aca.2019.12.021

Cited by 12 publications

(3 citation statements)

References 56 publications

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“…Lumogallion excitation was carried out with Colibri 7 led 475, dichroic Quad band Semrock DAPI/GFP/RFP/Cy5, while emission with Bandpass 575-640. The spectrum of Lumogallion emission is broad, ranging from 520 to over 650 nm [40,61] with a peak at around 580 nm. Due to the absence of a longpass emission filter, we used Bandpass 575-640.…”

Section: Image Acquisitionmentioning

confidence: 99%

Aluminum Enters Mammalian Cells and Destabilizes Chromosome Structure and Number

Tenan

Nicolle

Moralli

et al. 2021

IJMS

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Chromosome instability (CIN) consists of high rates of structural and numerical chromosome abnormalities and is a well-known hallmark of cancer. Aluminum is added to many industrial products of frequent use. Yet, it has no known physiological role and is a suspected human carcinogen. Here, we show that V79 cells, a well-established model for the evaluation of candidate chemical carcinogens in regulatory toxicology, when cultured in presence of aluminum—in the form of aluminum chloride (AlCl3) and at concentrations in the range of those measured in human tissues—incorporate the metal in a dose-dependent manner, predominantly accumulating it in the perinuclear region. Intracellular aluminum accumulation rapidly leads to a dose-dependent increase in DNA double strand breaks (DSB), in chromosome numerical abnormalities (aneuploidy) and to proliferation arrest in the G2/M phase of the cell cycle. During mitosis, V79 cells exposed to aluminum assemble abnormal multipolar mitotic spindles and appear to cluster supernumerary centrosomes, possibly explaining why they accumulate chromosome segregation errors and damage. We postulate that chronic aluminum absorption favors CIN in mammalian cells, thus promoting carcinogenesis.

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Section: Image Acquisitionmentioning

confidence: 99%

Aluminum Enters Mammalian Cells and Destabilizes Chromosome Structure and Number

Tenan

Nicolle

Moralli

et al. 2021

IJMS

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“…When water is not taken with food, it reaches directly from the esophagus to the stomach, where it comes into contact with the digestive juice (pH is between 2-3.5 and, as mentioned earlier, Aluminum dissolves more quickly in acidic medium) (Rogers and Simon 1999, Rondeau et al 2000, Samir and Rashed 2018, Walton 2012. In such cases the free Al +3 in the water is more absorbed by the body (Gardner et al 2003, Klotz et al 2017, Mendecki et al 2020, Yang et al 2019, Zhang et al 2016, Willhite et al 2014.…”

Section: Aluminum In the Body And Alzheimer's Disease (Ad)mentioning

confidence: 92%

Aluminum in food and potential role on Alzheimer’s disease of aluminum

Alkaya

Demirci

Şevik

2022

Turkish Journal of Engineering

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Several studies have shown the relationship between the aluminum exposure and the Alzheimer's disease. The gastrointestinal absorption of Aluminum (Al) is low. Also, If the renal filtering system works as needed, generally urine can be enough to eliminate overdose (rational over concentrations) of Al. But Al can be found in kinds of foods and drinks such as processed foods (because of additives, packaging materials, utensils…), fresh vegetables and fruits (because of soil) and even in drinking water therefore, in some cases, the Al level may pose a health risk. Chronic high concentration to Al exposure preferably intakes by oral, intravascular ways with also not having a good condition of Glomerular Filtering System of Kidneys (GFR). Nowadays, although mankind is having more Al by oral ways than past and many studies have been conducted to determine whether there is a relationship between aluminum and Alzheimer's disease(AD) or not. Therefore, this review is intended to provide a short summary of the works done in the past and it may warn people about Al intake in the next decade, therefore human can change their life to be more natural less industrial.

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“…In most cases, for trace analysis, preconcentration steps on a specific sorbent are needed. Some spectrofluorimetric methods show high sensitivity with low detection limit, but long response time [31][32][33][34][35][36][37]. Even though their detection systems were simple, but it shows weaknesses in sensitivity and selectivity.…”

Section: Introductionmentioning

confidence: 99%

Layer-by-Layer Assembly of Electroactive Dye/LDHs Nanoplatelet Matrix Film for Advanced Dual Electro-optical Sensing Applications

2020

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It proved that the most destructive effects of the toxic Al3+ ion on the human nervous system and disease that are involved with this system, such as Alzheimer's. The development of solid-state electrodes is still in its infancy during the sensor-based detection methods for Al3+. Hence, in this study, a novel flexible ITO/PET-based electrochemical solid-state sensor was designed and constructed. Modification of the surface of electrode bedding was done by layer-by-layer (LbL) assembly of Mg–Al LDH. nanoplatelets along with alizarin red S (ARS) in an interconnected matrix film. In the molecular design of sensing base of the electrode, the electroactive organic units (ARS molecules) present in the ITO/PET-layered (ARS/LDHs)n matrix are involved in electrochemical reactions when exposed to the target molecule (Al3+ ion), so the electrochemical changes of the new formed Al-chelated system are detectable. This type of sensor is used for sensitive and selective detection of Al3+. The minimum sheet resistance, morphology and high electrocatalytic activity of the modified matrix film are obtained in the fifth cycle of LbL assembly technique. In this electrochemical sensor, both electrochemical and optical methods were detected with high sensitivity and selectivity of Al3+, so that in a cyclic voltammetry electrochemical method, the lower detection limit of 10.1 nM with a linear range of [0.2–120 μM] was obtained compared to the fluorescence-based optical method.

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Self-plasticized, lumogallion-based fluorescent optical sensor for the determination of aluminium (III) with ultra-low detection limits

Abstract: Selfplasticized, lumogallion-based fluorescent optical sensor for the determination of aluminium (III) with ultra-low detection limits, Analytica Chimica Acta,

Cited by 12 publications

References 56 publications

Aluminum Enters Mammalian Cells and Destabilizes Chromosome Structure and Number

Aluminum Enters Mammalian Cells and Destabilizes Chromosome Structure and Number

Aluminum in food and potential role on Alzheimer’s disease of aluminum

Layer-by-Layer Assembly of Electroactive Dye/LDHs Nanoplatelet Matrix Film for Advanced Dual Electro-optical Sensing Applications

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