Self-protonating, plasma polymerized, superimposed multi-layered biomolecule nanoreservoir as blood-contacting surfaces

Wang, Wenxuan; Lü, Lei; Bei, Ho Pan; Li, Xiangyang; Du, Zeyu; Maitz, Manfred F.; Huang, Nan; Tu, Qiufen; Zhao, Xin; Yang, Zhilu

doi:10.1016/j.cej.2020.128313

Cited by 6 publications

(1 citation statement)

References 25 publications

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“…More recent advances in drug eluting stents include heparin-eluting stents [ 22 , 23 , 24 , 25 ] and combined heparin–nitric-oxide-eluting stents [ 26 , 27 ], which elute the anti-coagulant drug heparin and anti-bacterial nitric oxide. Several different methods are used to measure the amount of platelet adhesion and thrombus formation to these coatings, but these only typically reduce thrombus formation to a level in the range of 60–80%.…”

Section: Introductionmentioning

confidence: 99%

Anti-Thrombogenicity Study of a Covalently-Attached Monolayer on Stent-Grade Stainless Steel

2021

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Implantable devices fabricated from austenitic type 316L stainless steel have been employed significantly in medicine, principally because the material displays excellent mechanical characteristics and corrosion resistance. It is well known, however, that interaction of exposure of such a material to blood can initiate platelet adhesion and blood coagulation, leading to a harmful medical condition. In order to prevent undesirable surface platelet adhesion on biomaterials employed in procedures such as renal dialysis, we developed an ultrathin anti-thrombogenic covalently attached monolayer based on monoethylene glycol silane chemistry. This functions by forming an interstitial hydration layer which displays restricted mobility in the prevention of surface fouling. In the present work, the promising anti-thrombogenic properties of this film are examined with respect to platelet aggregation on 316L austenitic stainless steel exposed to whole human blood. Prior to exposure with blood, all major surface modification steps were examined by X-ray photoelectron spectroscopic analysis and surface free-angle measurement by contact angle goniometry. End-stage anti-thrombogenicity detection after 20 min of blood exposure at 100 s−1, 300 s−1, 600 s−1, 750 s−1, and 900 s−1 shear rates revealed that a significant reduction (>90%) of platelet adhesion and aggregation was achieved for surface-modified steel, compared with untreated material. This result is confirmed by experiments conducted in real time for 60-minute exposure to blood at 100 s−1, 600 s−1, and 900 s−1 shear rates.

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Section: Introductionmentioning

confidence: 99%

Anti-Thrombogenicity Study of a Covalently-Attached Monolayer on Stent-Grade Stainless Steel

2021

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A Polymeric Strategy Empowering Vascular Cell Selectivity and Potential Application Superior to Extracellular Matrix Peptides

Zhou

Chen

et al. 2022

Advanced Materials

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Endothelialization of vascular implants plays a vital role in maintaining the long‐term vascular patency. In situ endothelialization and re‐endothelialization is generally achieved by selectively promoting endothelial cell (EC) adhesion and, meanwhile, suppressing smooth muscle cell (SMC) adhesion. Currently, such EC versus SMC selectivity is achieved and extensively used in vascular‐related biomaterials utilizing extracellular‐matrix‐derived EC‐selective peptides, dominantly REDV and YIGSR. Nevertheless, the application of EC‐selective peptides is limited due to their easy proteolysis, time‐consuming synthesis, and expensiveness. To address these limitations, a polymeric strategy in designing and finding EC‐selective biomaterials using amphiphilic β‐peptide polymers by tuning serum protein adsorption is reported. The optimal β‐peptide polymer displays EC versus SMC selectivity even superior to EC‐selective REDV peptide regarding cell adhesion, proliferation, and migration of ECs versus SMCs. Study of the mechanism indicates that surface adsorption of bovine serum albumin, an abundant and anti‐adhesive serum protein, plays a critical role in the ECs versus SMCs selectivity of β‐peptide polymer. In addition, surface modification of the optimal β‐peptide polymer effectively promotes the endothelialization of vascular implants and inhibits intimal hyperplasia. This study provides an alternative strategy in designing and finding EC‐selective biomaterials, implying great potential in the vascular‐related biomaterial study and application.

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Titanium Dioxide Covalently Immobilized Citric Acid (TiO₂‐CA) Nanohybrid Coating of Neurovascular Flow Diverter to Improve Antithrombogenic and Pro‐Endothelialization Properties

Qian

Zhang

Gao

et al. 2022

Adv Materials Inter

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FDs can also treat aneurysms that had been previously intractable or untreatable. The mechanics lie in FDs being able to alter the direction of blood flow in the aneurysm's parent vessel to reduce the blood flow velocity inside it to favor thrombosis and therefore accomplish embolization. [2] It also serves to boost reendothelialization, remodel the vascular wall, and exclude aneurysms from circulation eventually. [3] To date, numerous studies have confirmed the efficacy and safety of FDs. [4] Although FDs are still in their infancy, there have already been several products available on the market, namely Pipeline (Medtronic, USA), p48 and p64flow modulation devices (Phenox, Germany), FRED (MicroVention, USA), Derivo (Acandis, Germany), Silk (Balt Extrusion, France), and Surpass/Streamline (Stryker, USA), and there will be more. [4b] The FDs currently used, however, are not without problems. The biggest problem is that they will trigger plasma protein adhesion and activate coagulation cascade reactions once they are placed into the target blood vessel, which leads readily to thrombosis. [3] Thus, dual antiplatelet therapy (DAPT), such as aspirin and clopidogrel, is mandatory for patients to avoid

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Self-protonating, plasma polymerized, superimposed multi-layered biomolecule nanoreservoir as blood-contacting surfaces

Cited by 6 publications

References 25 publications

Anti-Thrombogenicity Study of a Covalently-Attached Monolayer on Stent-Grade Stainless Steel

Anti-Thrombogenicity Study of a Covalently-Attached Monolayer on Stent-Grade Stainless Steel

A Polymeric Strategy Empowering Vascular Cell Selectivity and Potential Application Superior to Extracellular Matrix Peptides

Titanium Dioxide Covalently Immobilized Citric Acid (TiO₂‐CA) Nanohybrid Coating of Neurovascular Flow Diverter to Improve Antithrombogenic and Pro‐Endothelialization Properties

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Self-protonating, plasma polymerized, superimposed multi-layered biomolecule nanoreservoir as blood-contacting surfaces

Cited by 6 publications

References 25 publications

Anti-Thrombogenicity Study of a Covalently-Attached Monolayer on Stent-Grade Stainless Steel

Anti-Thrombogenicity Study of a Covalently-Attached Monolayer on Stent-Grade Stainless Steel

A Polymeric Strategy Empowering Vascular Cell Selectivity and Potential Application Superior to Extracellular Matrix Peptides

Titanium Dioxide Covalently Immobilized Citric Acid (TiO2‐CA) Nanohybrid Coating of Neurovascular Flow Diverter to Improve Antithrombogenic and Pro‐Endothelialization Properties

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Product

Resources

About

Titanium Dioxide Covalently Immobilized Citric Acid (TiO₂‐CA) Nanohybrid Coating of Neurovascular Flow Diverter to Improve Antithrombogenic and Pro‐Endothelialization Properties