Self-rated sleep characteristics and bother from nocturia

Vaughan, Camille P.; Eisenstein, Rina; Bliwise, Donald L.; Endeshaw, Yohannes; Nagamia, Zobair; Wolf, Renata; Johnson, Theodore M.

doi:10.1111/j.1742-1241.2011.02868.x

Cited by 26 publications

(25 citation statements)

References 24 publications

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“…The difference in baseline nocturia frequency between the sites is likely related to demographic differences between the cohorts rather than measurement method. Lastly, the measure of bother from both cohorts was collapsed into a binary variable, “No to little bother” vs “Moderate to great/extreme bother.” This is a similar categorization to that described by Vaughan et al and independent of nocturia frequency. The subjectivity of the construct of bother may have been a study limitation, although it was collected using standardized metrics.…”

Section: Discussionsupporting

confidence: 86%

Nocturnal voiding frequency does not describe nocturia‐related bother

Rose

Denys

Kumps

et al. 2019

Neurourology and Urodynamics

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Aim Nocturia frequency has been used as a measure of treatment efficacy for nocturia even though fluctuation of the symptom over time has been well described in the literature. Additionally, given the multifactorial causal pathway and clinically relevant comorbidities, frequency alone may be an insufficient marker of treatment direction. The aim of this study was to investigate factors associated with nocturia‐related bother to identify additional variables that may capture the impact of nocturia, direct clinical care and have potential to quantify treatment outcome. Methods Prospective data from tertiary hospital Urology and Continence cohorts were matched for identical variables to generate a sample of 204 datasets. Descriptive statistics were obtained to describe the two cohorts. Characteristics of patients were evaluated across levels of nocturia frequency and nocturia‐related bother using nonparametric methods; statistically significant differences between groups in each cohort were established. Results Nocturia frequency alone does not comprehensively reflect attributable bother. Five sleep variables (poor quality sleep, short time to first awakening to void, less than 7 hours of total sleep, primary sleep latency, and daytime sleepiness) and daily urinary urgency were significantly associated with high nocturia‐related bother. Attributable bother, despite high‐frequency nocturia, was minimized by male gender, lack of daily urinary urgency and good sleep quality. Poor health status, urinary urgency and sleep latency were associated with nocturia frequency. Conclusions Items of importance to individuals with nocturia have been identified from patient data. These variables have the potential to sit alongside change in nocturia frequency as potential markers of treatment response.

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Section: Discussionsupporting

confidence: 86%

Nocturnal voiding frequency does not describe nocturia‐related bother

Rose

Denys

Kumps

et al. 2019

Neurourology and Urodynamics

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“…Current treatment strategies are typically focused exclusively on the lower urinary tract 25-27 , even though several reports suggest that older adults with nocturia are more likely to find nocturia to be clinical bothersome if it is complicated by poor sleep quality 28,29 . Wide-spread usage of available drug treatments for nocturia that target the lower urinary tract such as bladder relaxants, alpha blockers, or desmopressin are more often limited in older adults because of their potential for higher side effects 10 .…”

Section: Discussionmentioning

confidence: 99%

Differences in the Association of Nocturia and Functional Outcomes of Sleep by Age and Gender: A Cross-sectional, Population-based Study

Vaughan

Fung

Huang

et al. 2016

Clinical Therapeutics

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Purpose Nocturia is associated with poor sleep quality; however, little is known about the relationship between nocturia and sleep quality across different workforce-relevant age groups of adults. This has implications for developing new treatment strategies that are well tolerated across populations. Materials and Methods We conducted a cross-sectional study involving merged data from the 2005-2006 and 2007-2008 waves of the National Health and Nutrition Examination Survey. Participants responded to validated questions on nocturia frequency and sleep, the Functional Outcomes of Sleep Questionnaire General Productivity subscale (FOSQ-gp, range 1-4),. Analyses included multivariable linear regression with stratification by gender to examine associations between nocturia frequency (higher worse) and the FOSQ-gp scores (lower scores indicating worse daytime function related to sleep disturbance). Findings Of 10,512 adults aged ≥ 20 who completed the survey, 9,148 (87%) had complete nocturia and FOSQ-gp data. The population age-adjusted prevalence of nocturia at least twice nightly was 21.1% among men and 26.6% among women (p<0.001), and nocturia increased with age (p<0.001). Compared to those with no or one episode of nocturia, those with nocturia at least twice nightly reported lower mean FOSQ-gp scores (3.65 (95% CI: 3.61-3.69) vs. 3.19 (95% CI: 3.09-3.31) for men;3.52 (95% CI: 3.48-3.56) vs. 3.09 (95% CI: 3.02-3.16) for women). Older adults (age > 65 years) with greater nocturia frequency reported worse FOSQ-gp scores compared to younger adults with similar nocturia frequency (p< 0.001 among men and women). Implications In a population-based sample of community-dwelling men and women, the association between nocturia and worsened functional outcomes of sleep was greater among adults older than 65 years - a group more vulnerable to drug side effects and in whom nocturia is typically multifactorial. Additionally, these analyses demonstrate that the association between nocturia and functional outcomes of sleep is stronger with increasing age among men. Effective treatment strategies that are well tolerated by older adults such as multicomponent treatments that simultaneously address the combined effects of lower urinary tract and sleep dysfunction are needed.

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“…[7][8][9][10][11][12][13][14][15] For those individuals who report nocturia as bothersome there is even a stronger correlation with disturbed sleep. 13,16 As noted, to date, no study of the relationship between sleep and nocturia has used objective measurements of sleep, nor have previous studies examined the relationship between sleep and nocturia prospectively, on a night-to-night basis. Such data could enable the comparison of nights with or without nocturia in the same individual.…”

Section: S C I E N T I F I C I N V E S T I G a T I O N Smentioning

confidence: 99%