Self-reported Medicinal Cannabis Use as an Alternative to Prescription and Over-the-counter Medication Use Among US Military Veterans

McNabb, Marion; Durante, Katherine A.; Trocchio, Sarah; Ritter, David J.; MacCaffrie, Randal; Brum, Ann; Mandile, Stephen; White, Steven

doi:10.1016/j.clinthera.2023.04.003

Cited by 6 publications

(3 citation statements)

References 28 publications

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Section: Discussionmentioning

confidence: 99%

“…In contrast to physicians, pharmacists are significantly more likely to believe that recommending/prescribing CBD could reduce opioid use for chronic pain, as some research suggests [ 53 ]. In their study, McNabb et al [ 53 ] proved that the consumption of pharmaceutical medications and other substances by veterans could potentially be reduced due to medicinal cannabis. Physicians and pharmacists agree that they do not have enough knowledge about the use of CBD for medical purposes and, therefore, cannot recommend it to their patients (94% and 88.7%, respectively).…”

Section: Discussionmentioning

confidence: 99%

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Knowledge and Attitudes of Cannabidiol in Croatia among Students, Physicians, and Pharmacists

Batinic,

Curkovic,

Bukic

et al. 2023

Pharmacy

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Due to cannabidiol’s health benefits and absence of serious side effects, its use is constantly growing. This is a survey-based cross-sectional study that was conducted to determine Croatian pharmacists’, physicians’, and students’ knowledge and attitudes about cannabidiol (CBD). Two questionnaires were created, one for students and the other for physicians and pharmacists. Our participants (in total 874: 473 students and 401 physicians and pharmacists) generally had positive attitudes towards CBD therapy as approximately 60% of them believe that CBD treatment is generally efficacious. Participants had positive attitudes toward the therapeutic value of CBD, especially pharmacists and pharmacy students (63.8% and 72.2%, respectively). Pharmacists were significantly more convinced that CBD could reduce the use of opioids prescribed for chronic pain (p < 0.05). Only 17.5% of students had read scientific papers about CBD, compared to a significantly higher percentage of physicians and pharmacists (43.0% and 47.8%, respectively) (p < 0.05). This study revealed a gap in knowledge regarding CBD, since 89.3% of pharmacists and physicians, as well as 84.8% of students, believe they need more education about CBD. We conclude that it is important to improve the educational curricula so that medical professionals can recommend CBD use to their patients when needed.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Knowledge and Attitudes of Cannabidiol in Croatia among Students, Physicians, and Pharmacists

Batinic,

Curkovic,

Bukic

et al. 2023

Pharmacy

View full text Add to dashboard Cite

show abstract

“…its neuropharmacological manipulation in rodent models of PTSD have been shown to affect the behavioral consequences of trauma exposure (Aliczki and Haller, 2015; Danandeh et al, 2018; Fotio et al, 2023); and iv.) reports on PTSD patients self-medicating with cannabis suggest that symptoms can be ameliorated through activation of the eCB system (McNabb et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

Endocannabinoid and neuroplasticity-related changes as susceptibility factors in a rat model of posttraumatic stress disorder

Szente,

Balla,

Varga

et al. 2024

Preprint

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Traumatic experiences result in the development of posttraumatic stress disorder (PTSD) in 10-25% of exposed individuals. While human clinical studies suggest that vulnerability is potentially linked to endocannabinoid (eCB) signaling, neurobiological PTSD vulnerability factors are poorly understood. Employing a rat model of PTSD, we characterized distinct resilient and vulnerable subpopulations based on generalized fear, a core symptom of PTSD. Vulnerable subjects showed lower prelimbic and higher ventral hippocampal levels of eCB 2-arachidonoyl-glycerol (2-AG). Ventral hippocampal 2-AG content positively correlated with the strength of fear generalization. Furthermore, vulnerability was associated with downregulation of neuronal activity and neuroplasticity markers, and altered expression of eCB-related genes. Unsupervised and semi-supervised statistical approaches highlighted that hippocampal gene expression patterns possess strong predictive power regarding vulnerability. Taken together, the marked eCB and neuroplasticity changes in vulnerable individuals associated with abnormal activity patterns in the fear circuitry possibly contribute to context coding deficits, resulting in generalized fear.

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Cannabis Research and Therapeutics: An International Quasi-experiment in Cannabis Policy

Johnson

Colby

2023

Clinical Therapeutics

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Self-reported Medicinal Cannabis Use as an Alternative to Prescription and Over-the-counter Medication Use Among US Military Veterans

Cited by 6 publications

References 28 publications

Knowledge and Attitudes of Cannabidiol in Croatia among Students, Physicians, and Pharmacists

Knowledge and Attitudes of Cannabidiol in Croatia among Students, Physicians, and Pharmacists

Endocannabinoid and neuroplasticity-related changes as susceptibility factors in a rat model of posttraumatic stress disorder

Cannabis Research and Therapeutics: An International Quasi-experiment in Cannabis Policy

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