Self-setting bioactive calcium–magnesium phosphate cement with high strength and degradability for bone regeneration

Wu, Fan; Wei, Jie; Guo, Han; Chen, Fangping; Hong, Hao; Liu, Changsheng

doi:10.1016/j.actbio.2008.06.020

Cited by 197 publications

(151 citation statements)

References 43 publications

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“…Therefore, mixed-type self-setting formulations consisting of calcium orthophosphates and other calcium salts (e.g., calcium sulfates [38][39][40][41][42][43][44][45][46][47], calcium pyrophosphate [48][49][50], calcium polyphosphates [51,52], calcium carbonates [33,[53][54][55], calcium oxide [56][57][58][59][60][61], calcium hydroxide [62][63][64], calcium aluminate [26,65,66], calcium silicates [67][68][69][70][71], etc. ), strontium orthophosphate [72][73][74], magnesium orthophosphate [74][75][76][77][78], magnesium oxide [79], Zn-containing compounds [80], as well as cements made of various ion substituted calcium orthophosphates (e.g., Ca 2 KNa(PO 4 ) 2 , NaCaPO 4 , Na 3...…”

Section: Introductionmentioning

confidence: 99%

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Dorozhkin¹

2012

IJMC

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In early 1980s, researchers discovered self-setting calcium orthophosphate cements, which are a bioactive and biodegradable grafting material in the form of a powder and a liquid. Both phases after mixing form a viscous paste that after being implanted sets and hardens within the body as either a non-stoichiometric calcium deficient hydroxyapatite (CDHA) or brushite, sometimes blended with un-reacted particles and other phases. As both CDHA and brushite are remarkably biocompartible and bioresorbable (therefore, in vivo they can be replaced with a newly forming bone), self-setting calcium orthophosphate cements represent a good correction technique of non-weight-bearing bone fractures or defects and appear to be very promising materials for bone grafting applications. Besides, these cements possess an excellent osteoconductivity, molding capabilities, and easy manipulation. Nearly perfect adaptation to the tissue surfaces in bone defects and a gradual bioresorption followed by new bone formation are additional distinctive advantages of calcium orthophosphate cements. Besides, reinforced formulations are available; those are described as calcium orthophosphate concretes. Furthermore, formulations with high viscosity, such as pastes and putties are also known. The discovery of self-setting formulations has opened up a new era in the medical application of calcium orthophosphates; several commercial compositions have already been introduced as a result. Many more formulations are in experimental stages. In this review, an insight into the self-setting calcium orthophosphate formulations, as excellent biomaterials suitable for both dental and bone grafting applications, has been provided.

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Section: Introductionmentioning

confidence: 99%

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Dorozhkin¹

2012

IJMC

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“…The hydration reaction retarder of MCPB was composed of sodium polyphosphate (STPP) and decahydrate of sodium tetraborate (STB) [14]. A certain amount of retarders was added to MCPB, then blended and pulverized with a ball mill, and finally followed by sieving (200 mesh) to standby [15].…”

Section: Preparation Of Mcpb Powdersmentioning

confidence: 99%

Preparation and osteogenic properties of magnesium calcium phosphate biocement scaffolds for bone regeneration

Niu

Guo

et al. 2013

J. Inst.

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The regenerative treatment of large osseous defects remains a formidable challenge in today. In the present study, we have synthesized biodegradable magnesium calcium phosphate biocement (MCPB) scaffolds with interconnected macroporous structure (100-600 µm), as well as good bioactivity, biocompatibility and proper degradatibility. The results revealed that the porosity increased from 52% to 80% of MCPB scaffolds while the compressive strength decreased from 6.1 MPa to 1.2 MPa. We further assessed the effects of scaffolds on the rabbit femur cavity defect model in vivo by using synchrotron radiation X-ray microCT and microCT imaging, indicating that the MCPB scaffolds underwent gradually degradation and promoted the extensive neo-bone formation.KEYWORDS: Computerized Tomography (CT) and Computed Radiography (CR); Medical-image reconstruction methods and algorithms, computer-aided so; X-ray radiography and digital radiography (DR)

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“…There have been methodical attempts to develop bioactive dental and prosthetic cements using phosphates in the past [97] and also to exploit antibacterial properties of these materials [98]. Since CBPC materials are phosphate based, they are uniquely positioned to match with composition of bones and teeth, in which hydroxyl apatite, a calcium phosphate hydrate, is the main component.…”

Section: Cbpc Products In the Marketmentioning

confidence: 99%

Recent Progress in Chemically Bonded Phosphate Ceramics

Wagh

2013

ISRN Ceramics

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Chemically bonded phosphate ceramics have made an excellent progress in the last 10 years and are poised to be one of the major inorganic room-temperature setting materials for nuclear, structural, dental, and prosthetic applications. They are also poised to be the first inorganic industrial coatings for fire and corrosion protection applications. In 2004 the author in his book, Chemically Bonded Phosphate Ceramics, presented general theory, compositions, methods of fabrication, and preliminary commercial products that appeared in the market ten years ago. This paper reviews that background and presents advances of last ten years with an emphasis on the recent applications in the nuclear field.

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Self-setting bioactive calcium–magnesium phosphate cement with high strength and degradability for bone regeneration

Cited by 197 publications

References 43 publications

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Preparation and osteogenic properties of magnesium calcium phosphate biocement scaffolds for bone regeneration

Recent Progress in Chemically Bonded Phosphate Ceramics

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