Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Dorozhkin, Sergey V.

doi:10.5923/j.ijmc.20110101.01

Cited by 71 publications

(77 citation statements)

References 585 publications

(936 reference statements)

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“…In addition, there are reinforced formulations, which, in a certain sense, might be defined as calcium orthophosphate concretes [122]. Furthermore, self-setting formulations able to form porous bioceramics are also available [459,460,467,468,470,479,480,514,543,625,626,627,628].…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Calcium Orthophosphate-Based Bioceramics

Dorozhkin¹

2013

Materials

231

153

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Various types of grafts have been traditionally used to restore damaged bones. In the late 1960s, a strong interest was raised in studying ceramics as potential bone grafts due to their biomechanical properties. A bit later, such synthetic biomaterials were called bioceramics. In principle, bioceramics can be prepared from diverse materials but this review is limited to calcium orthophosphate-based formulations only, which possess the specific advantages due to the chemical similarity to mammalian bones and teeth. During the past 40 years, there have been a number of important achievements in this field. Namely, after the initial development of bioceramics that was just tolerated in the physiological environment, an emphasis was shifted towards the formulations able to form direct chemical bonds with the adjacent bones. Afterwards, by the structural and compositional controls, it became possible to choose whether the calcium orthophosphate-based implants remain biologically stable once incorporated into the skeletal structure or whether they were resorbed over time. At the turn of the millennium, a new concept of regenerative bioceramics was developed and such formulations became an integrated part of the tissue engineering approach. Now calcium orthophosphate scaffolds are designed to induce bone formation and vascularization. These scaffolds are often porous and harbor different biomolecules and/or cells. Therefore, current biomedical applications of calcium orthophosphate bioceramics include bone augmentations, artificial bone grafts, maxillofacial reconstruction, spinal fusion, periodontal disease repairs and bone fillers after tumor surgery. Perspective future applications comprise drug delivery and tissue engineering purposes because calcium orthophosphates appear to be promising carriers of growth factors, bioactive peptides and various types of cells.

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Section: Biomedical Applicationsmentioning

confidence: 99%

Calcium Orthophosphate-Based Bioceramics

Dorozhkin¹

2013

Materials

231

153

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“…The latter mixture might be considered as the first prototype of the self-setting calcium orthophosphate formulations (reviewed in Refs. [283,284]). The next publications on this topic appeared in 1975 [285] and 1976 [286].…”

Section: The Twentieth Centurymentioning

confidence: 99%

History of Calcium Phosphates in Regenerative Medicine

Dorozhkin¹

2014

Springer Series in Biomaterials Science and Engineering

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The historical development of a scientific knowledge on calcium orthophosphates from the 1770s until 1950 is described. The chosen time scale starts with the earliest available studies of the 1770s (to the best of my findings, calcium orthophosphates had been unknown before), passes through the entire nineteenth century, and finishes in 1950, because since then the amount of publications on calcium orthophosphates rapidly increased and the subject became too broad. In addition, since publications of the second half of the twentieth century are easily accessible, the substantial amount of them has been already reviewed by other scientists. Many forgotten and poorly known historical facts and approaches have been extracted from the old publications. Then they have been analyzed, systematized, and reconsidered from the modern point of view. The reported historical findings clearly demonstrate that many famous scientists of the past contributed to calcium orthophosphate investigations. Furthermore, the significant quantity of the scientific facts and experimental approaches appears to have been known for very many decades, and, in fact, a good deal of the relatively recent investigations on the subject is just either a further development of the earlier studies or a rediscovery of the already forgotten knowledge. Keywords

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“…Keunggulan material dalam bentuk semen dibandingkan bentuk granul, blok, maupun serbuk yaitu bersifat dapat diinjeksikan ISSN : 1978-628X 162 (injectable) sehingga dapat mengisi ruang (kavitasi) pada tulang dan gigi yang cacat serta bersifat dapat mengeras sendiri [3,4] . Keunggulan lain dari semen ini yaitu dapat dicetak sehingga dapat juga digunakan sebagai pengisi pada tulang yang rusak [5,6] . Semen berbahan dasar kalsium fosfat dapat dibentuk melalui pencampuran satu atau lebih senyawa kalsium fosfat dalam suatu larutan berair.…”

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Pembuatan Pasta Dan Pembentukan Lapisan Tipis Hidroksi Apatit Karbonat

Samah¹,

Arief²,

Jamarun³

2015

J.Ris.Kim.

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Paste of Carbonated Hydroxyapatite (CHA) as a biocompatible material that can be used in the bone and teeth repair has been developed on preparation of thick film. CHA paste was prepared by mixing precipitate of CHA with CaSO 4 and polyethylene glycol (PEG) in 2-propanol as solvent. Paste was deposited on substrate to get thick films by screen printing method. X ray diffraction (XRD) analysis has shown hexagonal crystal structure and crystal size of CHA acquired 7,2 nm by Scherrer's method. Fourier Transform Infrared (FTIR) analysis has shown absorption spectra which indicating phosphate, carbonate, and hydroxide group. Size of this composite particles analyzed by PSA (particle size analyzer) about 3µm and pore size was 0.44-0.49 nm obtained from BET analysis, increased with the addition of CaSO 4 (0.44 to 0,49 nm). Rephrase PEG was found as an adhesive and homogenize paste on substrat surface. In addition, CHA paste also potentially can be used as bone cement. Keywords : Paste, thick film, carbonated hydroxyapatite PENDAHULUANSemen, pengisi (filler) atau material substitusi tulang mulai banyak dikembangkan para peneliti saat ini di Indonesia, mengingat produksi biomaterial khususnya yang memiliki fungsi sebagaimana yang tersebut diatas masih relatif sedikit.. Material yang telah digunakan dan diujikan sebagai bahan implan yaitu material dari jenis logam dan non-logam. Contoh beberapa material logam tersebut yaitu Ti, Ti alloy, stainless steel, dan alloy CrCoMo, sedangkan material nonlogam seperti keramik ZrO 2 , polimer polietilen, dan komposit C/C.

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Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Cited by 71 publications

References 585 publications

Calcium Orthophosphate-Based Bioceramics

Calcium Orthophosphate-Based Bioceramics

History of Calcium Phosphates in Regenerative Medicine

Pembuatan Pasta Dan Pembentukan Lapisan Tipis Hidroksi Apatit Karbonat

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