2024
DOI: 10.1364/boe.531573
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Self-supervised hybrid neural network to achieve quantitative bioluminescence tomography for cancer research

Beichuan Deng,
Zhishen Tong,
Xiangkun Xu
et al.

Abstract: Bioluminescence tomography (BLT) improves upon commonly-used 2D bioluminescence imaging by reconstructing 3D distributions of bioluminescence activity within biological tissue, allowing tumor localization and volume estimation—critical for cancer therapy development. Conventional model-based BLT is computationally challenging due to the ill-posed nature of the problem and data noise. We introduce a … Show more

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