Self-Supported Chiral Dirhodium Organic Frameworks Enables Efficient Asymmetric Cyclopropanation

Abstract

The development of heterogeneous chiral dirhodium catalysts for fabricating important bioactive substances and reducing the loss of noble metals has long been of significant interest. However, there still remains formidable synthetic challenges since it requires multiple steps of the synthetic process, and rhodium is easily leached from solid materials during the reaction. Here, we demonstrated a self-supported strategy based on the Suzuki−Miyaura coupling reaction to construct two chiral dirhodium organic frameworks for heterogeneous asymmetric catalysis. The synthetic approach is simple and efficient since it requires only a small number of preparation steps and does not require any catalyst supporting materials. The obtained chiral dirhodium materials can be highly efficient and recyclable heterogeneous catalysts for asymmetric cyclopropanation between diazooxindole and alkenes. Importantly, Rh 2 -MOCP-2 exhibited almost similar catalytic performance compared to homogeneous catalyst Rh 2 (S-Br-NTTL) 4 . The afforded catalytic performance (93.9% yield with 80.9% ee) highly surpasses previous heterogeneous dirhodium catalysts reported to date.