Sema4D expression and secretion are increased by HIF-1α and inhibit osteogenesis in bone metastases of lung cancer

Chen, Wugui; Sun, Jing; Sui, Weiwei; Yang, Sizhen; Zhang, Ying; Hu, Xu; Qiu, Hao; Xu, Shang-Cheng; Chu, Tongwei

doi:10.1007/s10585-018-9951-5

Cited by 27 publications

(18 citation statements)

References 54 publications

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“…Studies have confirmed that HIF-1α is closely related to the progression of lung disease under hypoxia (22)(23)(24). Intracranial hypoxia caused by TBI can enable HIF-1α to regulate the tolerance of epithelial cells by affecting the transcription and expression of nitric oxide synthase under hypoxic conditions (25,26). Decreased release of nitric oxide will cause continuous vasoconstriction and increase airway resistance.…”

Section: Discussionmentioning

confidence: 91%

Analysis of the influencing factors and nursing strategy for acute atelectasis after traumatic brain injury surgery

Gong

Zhou

et al. 2021

Ann Palliat Med

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Background: Acute atelectasis is common after traumatic brain injury (TBI), but the related factors and treatment are still unclear. This study is to analyze the independent risk factors for acute atelectasis after TBI and propose an interventional nursing strategy, in order to correct respiratory function and improve the prognosis of patients.Methods: The clinical data of 93 patients with TBI admitted to our hospital from April 2015 to October 2019 were retrospectively analyzed. Clinical data were analyzed by single factor analysis, the cutoff value of influencing factors was obtained by receiver operating characteristic (ROC) curve analysis, and the influencing factors for acute atelectasis after TBI were examined by multi-factor logistic regression.Results: Twenty-two patients (23.66%) were complicated with acute atelectasis during the observation period, while the remaining 71 patients (76.34%) did not have acute atelectasis. Univariate analysis showed that there were significant differences in the Glasgow Coma Scale (GCS), history of vomiting and aspiration, mannitol use, mechanical ventilation, hypoalbuminemia, and serum hypoxia-inducible factor-1α between the acute atelectasis group and the non-acute atelectasis group (P<0.05). The AUC area of HIF-1α level predicting acute atelectasis was 0.896 [95% confidence interval (CI): 0.814-0.978, P=0.042], and the cut-off value was 2.12 mmol/L, with a sensitivity of 76.9% and a specificity of 93.3%. Logistic regression analysis showed that a history of vomiting and aspiration [odds ratio (OR) 3.908, 95% confidence interval

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Section: Discussionmentioning

confidence: 91%

Analysis of the influencing factors and nursing strategy for acute atelectasis after traumatic brain injury surgery

Gong

Zhou

et al. 2021

Ann Palliat Med

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“…Sema4D: strongly expressed in osteoclasts, with no evidence of its expression in osteoblasts [ 87,94,96,144 ]…”

Section: Possible Signals From Intrabony Nerves To Bonementioning

confidence: 99%

“…[ 87,93 ] Studies found the upregulation of bone mass in Sema4D knockout animals compared to wild ones. [ 94–96 ] Semaphorin 4D can inhibit expression of osteoblast differentiation markers and reduce the formation of mineralized nodules in vitro and in vivo. [ 94,95 ] The function of Sema4D on bone remodeling has been reported to be sex‐dependent.…”

Section: Possible Signals From Intrabony Nerves To Bonementioning

confidence: 99%

“…[ 94–96 ] Semaphorin 4D can inhibit expression of osteoblast differentiation markers and reduce the formation of mineralized nodules in vitro and in vivo. [ 94,95 ] The function of Sema4D on bone remodeling has been reported to be sex‐dependent. [ 96 ] For post‐menopausal women, higher serum Sema4D was found among those with osteoporosis.…”

Section: Possible Signals From Intrabony Nerves To Bonementioning

confidence: 99%

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Crosstalk between Bone and Nerves within Bone

et al. 2021

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For the past two decades, the function of intrabony nerves on bone has been a subject of intense research, while the function of bone on intrabony nerves is still hidden in the corner. In the present review, the possible crosstalk between bone and intrabony peripheral nerves will be comprehensively analyzed. Peripheral nerves participate in bone development and repair via a host of signals generated through the secretion of neurotransmitters, neuropeptides, axon guidance factors and neurotrophins, with additional contribution from nerve‐resident cells. In return, bone contributes to this microenvironmental rendezvous by housing the nerves within its internal milieu to provide mechanical support and a protective shelf. A large ensemble of chemical, mechanical, and electrical cues works in harmony with bone marrow stromal cells in the regulation of intrabony nerves. The crosstalk between bone and nerves is not limited to the physiological state, but also involved in various bone diseases including osteoporosis, osteoarthritis, heterotopic ossification, psychological stress‐related bone abnormalities, and bone related tumors. This crosstalk may be harnessed in the design of tissue engineering scaffolds for repair of bone defects or be targeted for treatment of diseases related to bone and peripheral nerves.

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“…Through the JAK/STAT pathway, leptin can potentiate BMP9-induced osteogenic differentiation of MSCs (34). However, hypoxia inducible factor-1α (HIF-1α) is engaged in bone metastasis of lung cancer through promoting the expression and secretion of Sema4D to inhibit osteogenic differentiation (35). Besides, dickkopfrelated protein 1 (DKK1) (36) and tumor necrosis factor-α (TNF-α) (37) have been proved to be involved in inhibiting osteoblast differentiation.…”

Section: Osteolytic Metastasismentioning

confidence: 99%

Current progress and mechanisms of bone metastasis in lung cancer: a narrative review

Wu¹,

Pan²,

Mao³

et al. 2021

Transl Lung Cancer Res

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Lung cancer is a kind of malignant tumor with rapid progression and poor prognosis. Distant metastasis has been the main cause of mortality among lung cancer patients. Bone is one of the most common sites. Among all lung cancer patients with bone metastasis, most of them are osteolytic metastasis. Some serious clinical consequences like bone pain, pathological fractures, spinal instability, spinal cord compression and hypercalcemia occur as well. Since the severity of bone metastasis in lung cancer, it is undoubtedly necessary to know how lung cancer spread to bone, how can we diagnose it and how can we treat it. Here, we reviewed the process, possible mechanisms, diagnosis methods and current treatment of bone metastasis in lung cancer. We divided the process of bone metastasis in lung cancer into three steps: tumor invasion, tumor cell migration and invasion in bone tissue. It may be influenced by genetic factors, microenvironment and other adhesion-related factors. Imaging examination, laboratory examination, and pathological examination are used to diagnose lung cancer metastasis to bone. Surgery, radiotherapy, targeted therapy, bisphosphonate, radiation therapy and chemotherapy are the common clinical treatment methods currently. We also found some problems remained to be solved. For example, drugs for skeletal related events mainly target on osteoclasts at present, which increase the ratio of patients in osteoporosis and fractures in the long term. In all, this review provides the direction for future research on bone metastasis in lung cancer.

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Sema4D expression and secretion are increased by HIF-1α and inhibit osteogenesis in bone metastases of lung cancer

Cited by 27 publications

References 54 publications

Analysis of the influencing factors and nursing strategy for acute atelectasis after traumatic brain injury surgery

Analysis of the influencing factors and nursing strategy for acute atelectasis after traumatic brain injury surgery

Crosstalk between Bone and Nerves within Bone

Current progress and mechanisms of bone metastasis in lung cancer: a narrative review

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