2014
DOI: 10.1152/ajprenal.00177.2014
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Semaphorin 3A inactivation suppresses ischemia-reperfusion-induced inflammation and acute kidney injury

Abstract: Ranganathan P, Jayakumar C, Mohamed R, Weintraub NL, Ramesh G. Semaphorin 3A inactivation suppresses ischemia-reperfusion-induced inflammation and acute kidney injury. Am J Physiol Renal Physiol 307: F183-F194, 2014. First published May 14, 2014 doi:10.1152/ajprenal.00177.2014.-Recent studies show that guidance molecules that are known to regulate cell migration during development may also play an important role in adult pathophysiologic states. One such molecule, semaphorin3A (sema3A), is highly expressed a… Show more

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Cited by 47 publications
(41 citation statements)
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“…In normal mouse kidneys, Sema3A is expressed in distal and collecting tubules as well as in podocytes [17,18] (table 1). Following acute kidney injury induced by transient ischemia or by cisplatin, Sema3A protein expression is upregulated in distal and collecting tubules [17,18].…”
Section: Semaphorins and Plexins In Acute Kidney Injurymentioning
confidence: 99%
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“…In normal mouse kidneys, Sema3A is expressed in distal and collecting tubules as well as in podocytes [17,18] (table 1). Following acute kidney injury induced by transient ischemia or by cisplatin, Sema3A protein expression is upregulated in distal and collecting tubules [17,18].…”
Section: Semaphorins and Plexins In Acute Kidney Injurymentioning
confidence: 99%
“…Following acute kidney injury induced by transient ischemia or by cisplatin, Sema3A protein expression is upregulated in distal and collecting tubules [17,18]. Under these pathophysiological conditions, infiltrating immune cells are likely to serve as an additional source of Sema3A in the kidney [18,19]. The functional role of Sema3A in ischemia/reperfusion injury in vivo has been assessed by both pharmacological as well as genetic approaches employing mice, which carry a loss-of-function mutation in the Sema3A gene.…”
Section: Semaphorins and Plexins In Acute Kidney Injurymentioning
confidence: 99%
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