Semen Analysis in Myxedema

Griboff, Solomon I.

doi:10.1016/s0015-0282(16)34627-1

Cited by 29 publications

(13 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The association between hypothyroidism and spermatogenesis has already been studied thirty years ago in two clinical studies showing decreased seminal volume, motility and abnormal testicular biopsies. These studies included a small number of patients and often lacked a control population (15,16). More recent studies followed a number of postpubertal men after hypothyroidism was induced for three months.…”

Section: Discussionmentioning

confidence: 99%

Is systematic screening for thyroid disorders indicated in subfertile men?

Poppe

Glinoer²,

Tournaye³

et al. 2006

eur j endocrinol

View full text Add to dashboard Cite

Context: Data on the prevalence of thyroid disorders in male subfertility remain scarce. Objective: To investigate the prevalence of thyroid dysfunction and thyroid autoimmunity in men with normal and abnormal semen characteristics. Setting: Tertiary referral center for reproductive medicine of the University Hospital AZ-VUB, Brussels, Belgium. Patients and design: Two hundred and ninety-two men were stratified according to the presence of normal (group 1; n ¼ 39) or abnormal (group 2; n ¼ 253) semen characteristics. Thyroid function was assessed by serum thyrotropin (TSH) and free thyroxine (FT4), and thyroid peroxidase antibodies (TPO-Ab) for thyroid autoimmunity (TAI or TPO-Ab . 34 kU/l); both were correlated with semen characteristics. Main outcome measures: Semen characteristics were determined by World Health Organisation criteria (rapid þ slow motility $ 50% and concentration $20 £ 10 6 ) and Kruger criteria (morphology $ 14% normal cells). Results: In group 1, the mean (^S.D.) age was 33^4 years; serum TSH was 1.6 (0.3 -29.6) mU/l (median (range)) and FT4 was 12.2 (8.8 -15.6) ng/l. In group 2, the mean age was 33^5 years, serum TSH was 1.3 (0.3-5.2) mU/l and FT4 was 12.5 (8.4-17.5) ng/l; (compared with group 1 P ¼ 0:008 for TSH and P ¼ 0:037 for FT4). In both groups, one patient had increased TSH (2.6% and 0.4%; P ¼ not significant (ns)). In group 1, one patient had TAI and in group 2 twelve patients had TAI (2.6% compared with 4.7%; P ¼ ns). FT4 was an independent determinant for semen characteristics. Conclusions: The prevalence of thyroid dysfunction and autoimmunity is comparable between men with normal and abnormal semen characteristics. On the basis of these data, we do not advise systematic screening for thyroid disorders in subfertile men consulting a tertiary referral center for reproductive medicine.

show abstract

Section: Discussionmentioning

confidence: 99%

Is systematic screening for thyroid disorders indicated in subfertile men?

Poppe

Glinoer²,

Tournaye³

et al. 2006

eur j endocrinol

View full text Add to dashboard Cite

show abstract

“…Griboff (56), investigated five hypothyroid patients and all demonstrated normal sperm counts, whereas other authors (4,34,37,57) found morphological and spermatogenic alterations in testicular biopsies of prepubertal and adult hypothyroid patients. Hypothyroid prepubertal testis may present a preponderance of tubular compartment with early onset of spermatogenesis and no increase in the number of Leydig cells.…”

Section: Thyroid Hormone Disorders and Male Reproductionmentioning

confidence: 93%

Clinical implications of altered thyroid status in male testicular function

Wajner

Wagner

Maia

2009

Arq Bras Endocrinol Metab

View full text Add to dashboard Cite

Thyroid hormones are involved in the development and maintenance of virtually all tissues. Although for many years the testis was thought to be a thyroid-hormone unresponsive organ, studies of the last decades have demonstrated that thyroid dysfunction is associated not only with abnormalities in morphology and function of testes, but also with decreased fertility and alterations of sexual activity in men. Nowadays, the participation of triiodothyronine (T3) in the control of Sertoli and Leydig cell proliferation, testicular maturation, and steroidogenesis is widely accepted, as well as the presence of thyroid hormone transporters and receptors in testicular cells throughout the development process and in adulthood. But even with data suggesting that T3 may act directly on these cells to bring about its effects, there is still controversy regarding the impact of thyroid diseases on human spermatogenesis and fertility, which can be in part due to the lack of well-controlled clinical studies. The current review aims at presenting an updated picture of recent clinical data about the role of thyroid hormones in male gonadal function. RESUMOOs hormônios da tireoide estão envolvidos virtualmente no desenvolvimento e na manutenção de todos os tecidos. As gônadas masculinas foram, por décadas, consideradas insensíveis aos hormônios tireoidianos. No entanto, estudos mais recentes têm demonstrado que disfunções tireoidianas estão associadas não somente a anormalidades na morfologia e na função dos testículos, mas também à diminuição da fertilidade e alterações na atividade sexual masculina. Atualmente, o papel da triiodotironina (T3) no controle da proliferação das células de Sertoli e Leydig, maturação testicular e esteroidogênese é amplamente aceito, bem como a presença de transportadores e receptores para o hormônio tireoidiano nos testículos durante o período de desenvolvimento e a idade adulta. No entanto, apesar dos dados que indicam que o T3 atua diretamente nos testículos humanos, persistem controvérsias em relação ao impacto das doenças tireoidianas sobre a espermatogênese e a fertilidade, o que pode ser em parte devido à escassez de estudos clínicos nessa área. Essa revisão tem por objetivo apresentar um panorama de dados clínicos atualizados sobre o papel dos hormônios tireoidianos na função gonadal masculina. Arq Bras Endocrinol Metab. 2009;53(8):976-82 Descritores

show abstract

“…Griboff (92) investigated five patients with primary hypothyroidism (aged 30 -64 yr) and, whereas all patients demonstrated normal sperm counts, semen exposure to room air revealed a rapid drying of the material and sperm motility loss in two of five specimens. Another study by De la Balze et al (93) investigated six adult hypothyroid males (aged 17-59 yr) and showed that all patients demonstrated features of hypogonadotropic hypogonadism, with testicular biopsies revealing histological abnormalities.…”

Section: B Hypothyroidism In Malesmentioning

confidence: 99%

Thyroid Function and Human Reproductive Health

Krassas¹,

2010

View full text Add to dashboard Cite

Via its interaction in several pathways, normal thyroid function is important to maintain normal reproduction. In both genders, changes in SHBG and sex steroids are a consistent feature associated with hyper- and hypothyroidism and were already reported many years ago. Male reproduction is adversely affected by both thyrotoxicosis and hypothyroidism. Erectile abnormalities have been reported. Thyrotoxicosis induces abnormalities in sperm motility, whereas hypothyroidism is associated with abnormalities in sperm morphology; the latter normalize when euthyroidism is reached. In females, thyrotoxicosis and hypothyroidism can cause menstrual disturbances. Thyrotoxicosis is associated mainly with hypomenorrhea and polymenorrhea, whereas hypothyroidism is associated mainly with oligomenorrhea. Thyroid dysfunction has also been linked to reduced fertility. Controlled ovarian hyperstimulation leads to important increases in estradiol, which in turn may have an adverse effect on thyroid hormones and TSH. When autoimmune thyroid disease is present, the impact of controlled ovarian hyperstimulation may become more severe, depending on preexisting thyroid abnormalities. Autoimmune thyroid disease is present in 5-20% of unselected pregnant women. Isolated hypothyroxinemia has been described in approximately 2% of pregnancies, without serum TSH elevation and in the absence of thyroid autoantibodies. Overt hypothyroidism has been associated with increased rates of spontaneous abortion, premature delivery and/or low birth weight, fetal distress in labor, and perhaps gestation-induced hypertension and placental abruption. The links between such obstetrical complications and subclinical hypothyroidism are less evident. Thyrotoxicosis during pregnancy is due to Graves' disease and gestational transient thyrotoxicosis. All antithyroid drugs cross the placenta and may potentially affect fetal thyroid function.

show abstract

Semen Analysis in Myxedema

Cited by 29 publications

References 12 publications

Is systematic screening for thyroid disorders indicated in subfertile men?

Is systematic screening for thyroid disorders indicated in subfertile men?

Clinical implications of altered thyroid status in male testicular function

Thyroid Function and Human Reproductive Health

Contact Info

Product

Resources

About