Semi-micro high-performance liquid chromatographic analysis of tiropramide in human plasma using column-switching

Baek, Soo Kyoung; Lee, Seung Seok; Park, Eun Jeon; Sohn, Dong Hwan; Lee, Hye Suk

doi:10.1016/s0731-7085(02)00570-8

Cited by 7 publications

(6 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In other words, the previously reported PK parameter values of tiropramide were similar to our PK results obtained by NCA analysis. After oral administration of 100 mg of tiropramide in humans, the obtained NCA PK parameters (as previously reported values) were 2.34-6.99 h for t 1/2 , 0.66-1.6 h for T max , 77.4-111 ng/mL for C max , and 267.7-812.7 h•ng/mL for AUC [6,12,[18][19][20][21]. On the other hand, the NCA PK parameters in this study were 3.41 ± 1.99 h for t 1/2 , 1.74 ± 0.63 h for T max , 69.07 ± 59.74 ng/mL for C max , and 280.34 ± 199.96 h•ng/mL for AUC, which were similar to the previously reported values.…”

Section: Discussionsupporting

confidence: 79%

See 1 more Smart Citation

Population Pharmacokinetic Analysis of Tiropramide in Healthy Korean Subjects

et al. 2020

View full text Add to dashboard Cite

The purpose of this study was to perform population pharmacokinetic (PPK) analysis of tiropramide in healthy Korean subjects, as well as to investigate the possible effects of various covariates on pharmacokinetic (PK) parameters of tiropramide. Although tiropramide is commonly used in digestive system-related diseases as an antispasmodic, PPK reporting and factors affecting PKs are not clearly reported. Thus, this study for healthy subjects is very significant because it could find new covariates in patients that had not been reported before or predict PPK for patients in the clinic by establishing PPK in healthy adults. By using Phoenix NLME, PK, demographic, and genetic data (collected to explain PK diversity of tiropramide in population) analyses were performed. As a basic model, a one-compartment with first-order absorption and lag-time was established and extended to include covariates that influenced the inter-subject variability. The total protein significantly influenced the distribution volume and systemic clearance of tiropramide, but genetic factors such as ABCB1 (1236C>T, 2677G>T/A, and 3435C>T), CYP2D6 (*1 and *10), OCT2 (808G>T), and PEPT1 (1287G>C) genes did not show any significant association with PK parameters of tiropramide. The final PPK model of tiropramide was validated, and suggested that some of the PK diversity in the population could be explained. Herein, we first describe the establishment of the PPK model of tiropramide for healthy Korean subjects, which may be useful as a dosing algorithm for the diseased population.

show abstract

Section: Discussionsupporting

confidence: 79%

“…Plasma concentrations of tiropramide were determined using a validated column-switching semi-micro high-performance liquid chromatography (HPLC) method based on a previous study [12].…”

Section: Determination Of Plasma Tiropramide Concentrationsmentioning

confidence: 99%

Population Pharmacokinetic Analysis of Tiropramide in Healthy Korean Subjects

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Literature search revealed that very few pharmacokinetic studies are published and the reported methods are based on liquid chromatography-tandem mass spectrometry [2], gas chromatography/nitrogen phosphorus detector [3,4] semi-micro HPLC using column switching [5] and gas chromatography coupled to mass spectrometry [6]. Although the reported methods are sensitive and accurate but are expensive, and labor intensive.…”

Section: Introductionmentioning

confidence: 99%

A simple sample preparation with HPLC–UV method for estimation of tiropramide from plasma: Application to bioequivalence study

Khan

Loya

Natvarlal

2007

Journal of Pharmaceutical and Biomedical Analysis

View full text Add to dashboard Cite

“…Tiropramide was extensively metabolized to N-desethyltiropramide, N-desethyl-N-despropyltiropramide, N-despropyltiropramide and hydroxytiropramide via N-desethylation, N-despropylation, and hydroxylation at N-propyl after oral administration of tiropramide to rats [3] and human [4,5]. A few methods for the determination of tiropramide in biological fluids were reported using gas-liquid chromatography (GLC) [4], GLC/mass spectrometry (GLC/MS) [5] and semi-micro high-performance liquid chromatography (HPLC) method [6]. However, those methods require relatively long run time.…”

Section: Introductionmentioning

confidence: 99%