Semi-solid functionalized nanostructured lipid carriers loading thymol for skin disorders

Folle, Camila; Sánchez‑López, Elena; Mallandrich, Mireia; Díaz‑Garrido, Natalia; Suñer-Carbó, Joaquim; Halbaut, Lyda; Carvajal-Vidal, Paulina; Marqués, Ana M.; Espina, Marta; Badia, Josefa; Baldoma, Laura; García, Maria Luisa; Calpena, Ana Cristina

doi:10.1016/j.ijpharm.2023.123732

International Journal of Pharmaceutics

2024

DOI: 10.1016/j.ijpharm.2023.123732

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Semi-solid functionalized nanostructured lipid carriers loading thymol for skin disorders

Camila Folle,

Elena Sánchez‑López,

Mireia Mallandrich

et al.

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Cited by 3 publications

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Dietary monoterpenoids and human health: Unlocking the potential for therapeutic use

Vyhlídalová,

Ondrová,

Zůvalová

2024

Biochimie

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Dietary monoterpenoids and human health: Unlocking the potential for therapeutic use

Vyhlídalová,

Ondrová,

Zůvalová

2024

Biochimie

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Progress in Topical and Transdermal Drug Delivery Research—Focus on Nanoformulations

Lunter,

Klang,

Eichner

et al. 2024

Pharmaceutics

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Skin is the largest organ and a multifunctional interface between the body and its environment. It acts as a barrier against cold, heat, injuries, infections, chemicals, radiations or other exogeneous factors, and it is also known as the mirror of the soul. The skin is involved in body temperature regulation by the storage of fat and water. It is an interesting tissue in regard to the local and transdermal application of active ingredients for prevention or treatment of pathological conditions. Topical and transdermal delivery is an emerging route of drug and cosmetic administration. It is beneficial for avoiding side effects and rapid metabolism. Many pharmaceutical, technological and cosmetic innovations have been described and patented recently in the field. In this review, the main features of skin morphology and physiology are presented and are being followed by the description of classical and novel nanoparticulate dermal and transdermal drug formulations. The biophysical aspects of the penetration of drugs and cosmetics into or across the dermal barrier and their investigation in diffusion chambers, skin-on-a-chip devices, high-throughput measuring systems or with advanced analytical techniques are also shown. The current knowledge about mathematical modeling of skin penetration and the future perspectives are briefly discussed in the end, all also involving nanoparticulated systems.

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Lipid-Based Formulation of Baricitinib for the Topical Treatment of Psoriasis

Mohammadi-Meyabadi,

Mallandrich,

Beirampour

et al. 2024

Pharmaceutics

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Background: Baricitinib, commonly used for autoimmune diseases, is typically administered orally, which can lead to systemic adverse effects. A topical formulation could potentially offer localized therapeutic effects while minimizing these side effects. Objectives: This study focuses on developing a lipid-based topical formulation of baricitinib (BCT-OS) for treating psoriasis. Methods: The optimized formulation was then assessed for physical, chemical, and biopharmaceutical characterization. Furthermore, the anti-inflammatory efficacy of the formulation was tested in a model of psoriasis induced by imiquimod in mice, and its tolerance was determined by the evaluation of biomechanical skin properties and an inflammation test model induced by xylol in mice. Results: BCT-OS presented appropriate characteristics for skin administration in terms of pH, rheology, extensibility, and stability. The formulation also demonstrated a notable reduction in skin inflammation in the mouse model, and high tolerability without affecting the skin integrity. Conclusions: BCT-OS shows promise as an alternative treatment for psoriasis, offering localized therapeutic benefits with a potentially improved safety profile compared to systemic administration.

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Semi-solid functionalized nanostructured lipid carriers loading thymol for skin disorders

Cited by 3 publications

References 32 publications

Dietary monoterpenoids and human health: Unlocking the potential for therapeutic use

Dietary monoterpenoids and human health: Unlocking the potential for therapeutic use

Progress in Topical and Transdermal Drug Delivery Research—Focus on Nanoformulations

Lipid-Based Formulation of Baricitinib for the Topical Treatment of Psoriasis

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