2023
DOI: 10.1002/cbdv.202300609
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Semicarbazides Carrying Indole Core: Synthesis, Cytotoxicity Evaluation against Human Breast Cancer Cell Lines, and Molecular Modeling Studies

Beyza Çelik,
Sümeyye Buran Uğur,
Münevver Baran
et al.

Abstract: In this article, we report the synthesis and cytotoxicity evaluation of novel indole‐carrying semicarbazide derivatives (IS1‐IS15). The target molecules were obtained by the reaction of aryl/alkyl isocyanates with 1H‐indole‐2‐carbohydrazide that was in‐house synthesized from 1H‐indole‐2‐carboxylic acid. Following structural characterization by 1H‐NMR, 13C‐NMR, and HR‐MS, IS1‐IS15 were investigated for their cytotoxic activity against human breast cancer cell lines, MCF‐7 and MDA‐MB‐231. According to the data o… Show more

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