Seminal plasma hormone concentration after oral application of progesterone

Feuring, Martin; Bertsch, Thomas; Bm, Tran; Rossol-Haseroth, Karin; Lösel, Ralf; Hc, Tillmann; Schultz, André; Weigel, M.; Wehling, Martin

doi:10.5414/cpp40047

Cited by 2 publications

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“…3 In addition to these genomic effects, several studies have also described nongenomic, rapid effects of GCs on immune cells. [4][5][6][7] Dexamethasone (DM) can attenuate the early events of the T-cell receptor (TCR)-induced signaling cascade, including the activation of Src kinases via the GCR. GCRdeficient Jurkat cells and human T cells treated with the GCR blocker, Ru486, during cell activation failed to demonstrate any inhibition in kinase activation in response to DM.…”

Section: Introductionmentioning

confidence: 99%

Dexamethasone augments CXCR4-mediated signaling in resting human T cells via the activation of the Src kinase Lck

Ghosh

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Collins

et al. 2009

Blood

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Dexamethasone (DM) is a synthetic member of the glucocorticoid (GC) class of hormones that possesses antiinflammatory and immunosuppressant activity and is commonly used to treat chronic inflammatory disorders, severe allergies, and other disease states. Although GCs are known to mediate welldefined transcriptional effects via GC receptors (GCR), there is increasing evidence that GCs also initiate rapid nongenomic signaling events in a variety of cell types. Here, we report that DM induces the phosphorylation of Lck IntroductionGlucocorticoids (GCs) are used to treat diseases with an inflammatory or immune-mediated component, including autoimmune diseases, graft rejection, and leukemia. GCs act via the T-cell intracellular GC receptor (GCR) and may negatively regulate the expression of numerous genes associated with proinflammatory cytokine signaling. 1,2 This inhibition of gene transcription appears to result from the ability of the GC/GCR complex to interfere with the activity of numerous transcription factors, either by binding to negative regulatory elements in the promoter region or through protein/protein interactions, impeding the ability of these factors to positively direct gene transcription. 3 In addition to these genomic effects, several studies have also described nongenomic, rapid effects of GCs on immune cells. [4][5][6][7] Dexamethasone (DM) can attenuate the early events of the T-cell receptor (TCR)-induced signaling cascade, including the activation of Src kinases via the GCR. GCRdeficient Jurkat cells and human T cells treated with the GCR blocker, Ru486, during cell activation failed to demonstrate any inhibition in kinase activation in response to DM. Interestingly, many of the inhibitory effects of GC have been observed in activated human or rodent T cells and immune cell subpopulations; however, the effects of DM on resting T cells are unclear.CXCR4, a chemokine receptor specific for the chemokine ligand, CXCL12, is expressed on leukocytes and is involved in the recirculation of naive lymphocytes into lymphoid tissue. 8 This receptor also plays a role in the retention of stem cells, differentiating B cells and neutrophils within bone marrow 9 and controls B-cell positioning within lymph nodes, where its expression is regulated by interleukin-4. 10 CXCR4 has been found to play a critical role in thymocyte chemotaxis and apoptosis 11 as well as thymic development. 12 CXCL12 was found to counteract the effects of DM on the apoptosis of CD4 ϩ CD8 ϩ T cells. Interestingly, several reports have also demonstrated that exposure of T-cell lines to GC can up-regulate cell surface CXCR4 expression. 13,14 Signals delivered through CXCR4-CXCL12 interactions result in potent chemotactic and pro-adhesive signals facilitating T-and B-lymphocyte migration. [15][16][17] Several reports have suggested that the activation of the Src kinase, Lck, on treatment of T cells with CXCL12 may be involved in orchestrating the downstream signals necessary for chemotaxis. 18,19 CXCR4 physically associates with the TC...

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Section: Introductionmentioning

confidence: 99%

Dexamethasone augments CXCR4-mediated signaling in resting human T cells via the activation of the Src kinase Lck

Ghosh

Baatar

Collins

et al. 2009

Blood

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Occurrence and reproductive roles of hormones in seminal plasma

Vítků

Kolátorová

Hampl

2017

Basic Clin. Androl.

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Only 2–5% of seminal fluid is composed of spermatozoa, while the rest is seminal plasma. The seminal plasma is a rich cocktail of organic and inorganic compounds including hormones, serving as a source of nutrients for sperm development and maturation, protecting them from infection and enabling them to overcome the immunological and chemical environment of the female reproductive tract. In this review, a survey of the hormones found in human seminal plasma, with particular emphasis on reproductive hormones is provided. Their participation in fertilization is discussed including their indispensable role in ovum fertilization. The origin of individual hormones found in seminal plasma is discussed, along with differences in the concentrations in seminal plasma and blood plasma. A part of review is devoted to methods of measurement, emphasising particular instances in which they differ from measurement in blood plasma. These methods include separation techniques, overcoming the matrix effect and current ways for end-point measurement, focusing on so called hyphenated techniques as a combination of chromatographic separation and mass spectrometry. Finally, the informative value of their determination as markers of male fertility disorders (impaired spermatogenesis, abnormal sperm parameters, varicocele) is discussed, along with instances where measuring their levels in seminal plasma is preferable to measurement of levels in blood plasma.

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Seminal plasma hormone concentration after oral application of progesterone

Cited by 2 publications

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Dexamethasone augments CXCR4-mediated signaling in resting human T cells via the activation of the Src kinase Lck

Dexamethasone augments CXCR4-mediated signaling in resting human T cells via the activation of the Src kinase Lck

Occurrence and reproductive roles of hormones in seminal plasma

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