2019
DOI: 10.1016/j.theriogenology.2019.06.018
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Seminal plasma mitigates the adverse effect of uterine fluid on boar spermatozoa

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Cited by 11 publications
(8 citation statements)
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“…Seminal plasma is a complex mixture of secretions originated from testes, epididymis and male accessory sexual glands. It has been proved that seminal plasma plays an important roles on sperm fertilizing ability and exerts important effects on female reproductive physiology (Luongo et al., 2019). The exposure of spermatozoa to small molecules such as metabolites can improve or hinder sperm fertilizing capacity, even if semen is diluted in extender during preservation of spermatozoa (Xu et al., 2004; Yeste et al., 2008).…”
Section: Introductionmentioning
confidence: 99%
“…Seminal plasma is a complex mixture of secretions originated from testes, epididymis and male accessory sexual glands. It has been proved that seminal plasma plays an important roles on sperm fertilizing ability and exerts important effects on female reproductive physiology (Luongo et al., 2019). The exposure of spermatozoa to small molecules such as metabolites can improve or hinder sperm fertilizing capacity, even if semen is diluted in extender during preservation of spermatozoa (Xu et al., 2004; Yeste et al., 2008).…”
Section: Introductionmentioning
confidence: 99%
“…In mice and pigs, there is robust evidence of modulation of the maternal environment through SP which positively impacts embryo survival and development 6,10,12,23,32 . However, similar evidence in cattle is sparse and seemingly contradictory.…”
Section: Discussionmentioning
confidence: 99%
“…Spermatozoa are highly specialized cells, programmed for destabilization during their journey to the site of fertilization. They are covered by SP proteins whose adsorption to the plasma membrane prevent its destabilization and disruption, once gathered under the title of “decapacitation factors” [ 210 ], relevant for in vitro processing and in vivo survival [ 100 , 242 ]. However, this friendly role can soon change.…”
Section: What Else Can Be Done With Our Current Knowledge Of Sp?mentioning
confidence: 99%
“…The SP of most species contains differential amounts of a 5-20 kDa peptidomes with pro-and anti(or tolerance-related)-cytokines and chemokines [11]. Both in human and boar, cytokine amounts of both inflammatory (tumor necrosis factor (TNF)-α, interferonγ (IFN-γ), interleukins (IL) −6, −8, granulocyte-macrophage colony-stimulating factor It is thus evident that the proteins of the SP exert multiple functions, starting with their general influence as a vehicle aiding sperm survival when semen is highly extended [43,87] or processed [22,98,99], to specific events while adsorbed to the sperm plasma membrane, reinforcing its stability during uterine sperm transport [100]. Besides, specific SP-proteins have pro-inflammatory capacities, contributing as a trigger for the well-known post-mating primary, transient inflammation whose role is to cleanse the intra-uterine lumen from foreign cells, proteins and eventual pathogens, as well as from excessive spermatozoa, e.g., those not involved neither in colonization of the tubal reservoirs or fertilization.…”
Section: Cytokines In the Seminal Plasma: The Effectors Of Such Signaling?mentioning
confidence: 99%