Seminoma, Sertolioma, and Leydigoma in Dogs: Clinical and Morphological Correlations

Abstract

The study aimed at presenting the most frequent male gonadal tumours in dogs, their clinical and histopathological aspects, at outlining aetiopathogenesis and differential diagnosis of the tumours. As examples of the most frequently manifested testicular tumours, three clinical cases were presented, involving tumour of interstitial (Leydig) cells, tumour of Sertoli cells, and seminoma. Respective clinical diagnosis employed USG, X-ray patterns, and morphological and biochemical tests. The surgically sampled material was stained with H+E and an attempt was made to establish expression of E-cadherin, calretinin, and Ki-67. It was shown that histopathological diagnosis of testicular tumours in dogs is frequently very difficult and complex and requires multidirectional studies.

Inhibin-α, E-cadherin, calretinin and Ki-67 antigen in the immunohistochemical evaluation of canine and human testicular neoplasms

“…Seminomas, Leydig cell tumors and Sertoli cell tumors represent the most frequent types of canine testicular neoplasms [1][2][3][4]. Although these tumors are also diagnosed in humans, their incidence is markedly lower than in dogs.…”

Bilaterally diffuse malignant seminoma in a dog

“…It is known that cryptorchidism is an important predisposing factor in the tumors. Seminomas get the risk of cryptorchidism rise to 15 fold, though it is increased to 26 fold in sertoli tumors (1,3,8). The testicle tumors were reported unilaterally and bilaterally, however, they are often occured in Right and in Boxer than other breeds (5,6,9).…”

“…Testicle tumors are commonly seen on older dog and other species although the tumors in dogs show low frequency (4.6-6%) but seminomas consist of 33% of all tumors of dog (1,3,11). Seminomas, sertoli cell tumors and Leydig cell tumors are most encountered among primary testicle tumors according to World Health Organization (WHO) (1,4,6,7,9).…”

“…In general, tumors are occurred bilaterally or unilaterally in right testicle in elderly dogs (1,2,7,9). In the case, tumor was seen bilaterally in 6 years old Terrier.…”

“…Seminomas, sertoli cell tumors and Leydig cell tumors are most encountered among primary testicle tumors according to World Health Organization (WHO) (1,4,6,7,9). And histologically evaluated mainly in two types (tubular and diffuse type).…”