Semisolid Formulation Containing a Nanoencapsulated Sunscreen: Effectiveness, &lt;I&gt;In Vitro&lt;/I&gt; Photostability and Immune Response

Paese, Karina; Jäger, Alessandro; Poletto, Fernanda; Pinto, Eduardo Costa; Rossi-Bergmann, Bartira; Pohlmann, Adriana Raffin; Guterres, Sílvia Stanisçuaski

doi:10.1166/jbn.2009.1028

Cited by 56 publications

(36 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Also, an increase in the skin hydration can be observed due to the occlusive properties of the nanoparticles [10]. More advantages include the physical stabilisation of formulations [11] and prevention of drug degradation [12,13] as well as an agreeable sensorial [10].…”

Section: Introductionmentioning

confidence: 99%

Vegetable oils as core of cationic polymeric nanocapsules: influence on the physicochemical properties

Contri

Ribeiro

Fiel

et al. 2012

Journal of Experimental Nanoscience

Self Cite

View full text Add to dashboard Cite

Vegetable oils might be alternatives to mineral or synthetic oils used in nanostructured systems for cutaneous application, due to their advantages with regard to skin care and protection. In this study, we propose the use of vegetable oils (Brazil nut, sunflower seed, olive, rose hip, grape seed and carrot oils) as oily core of Eudragit RS100Õ nanocapsules and determine their influence on the physicochemical properties of those nanoparticles, in comparison with nanocapsules with capric/caprylic triglycerides as oily core. The formulations containing vegetable oils as core presented pH values suitable for topical application, average diameter close to 280 nm (SPAN around 2.5) and zeta potential close to þ7 mV, due to the cationic properties of the polymer. Their viscosities were not affected by the type of oil used as core. By means of multiple light scattering, a reversible particle creaming phenomenon was observed for all the formulations. The nanocapsules prepared using Brazil nut, sunflower seed, olive, grape seed, rose-hip and carrot oils presented some distinct physicochemical properties when compared to nanocapsules obtained with capric/caprylic triglycerides: a higher size and SPAN value, a lower number of particles and a higher tendency to reversible creaming. Those findings are probably related to the lower density and higher viscosity of the vegetable oils.

show abstract

Section: Introductionmentioning

confidence: 99%

Vegetable oils as core of cationic polymeric nanocapsules: influence on the physicochemical properties

Contri

Ribeiro

Fiel

et al. 2012

Journal of Experimental Nanoscience

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, its physicochemical characteristics (M¯ w = 228.5 g ؒ mol -1 ; log P: 3.58) favor its permeation through the skin [16] . In a previous study, we reported that the nanoencapsulation of benzophenone-3 improved both its photostability and effectiveness compared to the nonencapsulated sunscreen [17] . Furthermore, some studies showed that polymeric nanocapsules can avoid the favorable permeation and the risk of systemic absorption of lipophilic substances like sunscreens [18,19] .…”

mentioning

confidence: 96%

Innovative Sunscreen Formulation Based on Benzophenone-3-Loaded Chitosan-Coated Polymeric Nanocapsules

Siqueira

Contri

Paese

et al. 2011

Skin Pharmacol Physiol

View full text Add to dashboard Cite

Aim: To evaluate the effect of cationic coating of polymeric nanocapsules in sunscreen formulations on the in vitro skin penetration of benzophenone-3. Methods: Benzophenone-3-loaded nanocapsules were prepared by the interfacial deposition of poly(Ε-caprolactone) and coated by using a chitosan solution. The nanoparticles were characterized and incorporated in hydrogels. The presence of nanoparticles in hydroxyethyl cellulose gels was observed by transmission electron microscopy and photon correlation spectroscopy. Penetration studies were carried out using Franz cells with porcine skin membranes. Results: Benzophenone-3-loaded chitosan-coated nanocapsules presented a mean size of 202 ± 7 nm and positive zeta potential (+21 ± 1 mV), while these values for the uncoated nanocapsules were 175 ± 1 nm and –8 ± 1 mV. Penetration profiles showed that a higher amount of benzophenone-3 remained at the skin surface and a lower amount was found in the receptor compartment after the application of the formulation containing chitosan-coated nanocapsules compared to a formulation containing its free form. Conclusions: Hydrogel containing benzophenone-3 chitosan-coated nanocapsules represents an innovative formulation to overcome limitations of sunscreen daily use.

show abstract

“…No entanto, a extração do fármaco a partir deste sistema nanoestruturado para fins de quantificação é extremamente difícil, sendo necessária a utilização de uma mistura de solventes que possibilite a solubilização da parede polimérica, bem como do ativo. 10 Assim sendo, o desenvolvimento de um método simples, rápido e preciso para a extração e quantificação do adapaleno a partir das nanocápsulas é altamente desejável. Em vista disso, o presente trabalho teve como objetivo desenvolver e validar um método analítico para quantificação do adapaleno através de cromatografia líquida de alta eficiência (CLAE).…”

Section: Introductionunclassified

Validação de método analítico por cromatografia líquida de alta eficiência para doseamento do adapaleno em suspensões de nanocápsulas

Barrios¹,

Farias²,

Roggia³

et al. 2011

Quím. Nova

View full text Add to dashboard Cite

Recebido em 27/10/10; aceito em 22/2/11; publicado na web em 12/5/11 VALIDATION OF ANALYTICAL METHOD BY HPLC FOR DETERMINATION OF ADAPALENE IN SUSPENSIONS OF NANOCAPSULES. Adapalene is a retinoid drug often used for disorders of the skin, mainly acne. In this work, an analytical method for the quantification of adapaleno in suspensions of nanocapsules by HPLC was developed and validated. The method was linear in the range of 10-30 μg mL -1 , with a good correlation coefficient (r = 0.994). Precision and accuracy analysis showed low relative standard deviation (< 4.6%) and a good recovery percentual (98.2-106.9%). The procedure was specific, linear, precise, exact and robust so that the method can be applied in quantification of adapalene in suspensions of nanocapsules.Keywords: adapalene; validation; HPLC. INTRODUÇÃOCom o nome químico ácido 6-[3-(1-adamantil)-4-metoxifenil]-2-naftoico, fórmula molecular C 28 H 28 O 3 e massa molar de 412,52 g mol -1 , 1 o adapaleno (Figura 1) é um pó branco solúvel em tetraidrofurano, ligeiramente solúvel em etanol e praticamente insolúvel em água.2 Este fármaco é um retinoide de terceira geração derivado do ácido naftoico, 3 que possui atividade comedolítica e anti-inflamatória apropriada, sendo uma alternativa tópica para o tratamento da acne. 4A acne é uma doença genético-hormonal, 5 que envolve a unidade pilossebácea, sendo mais frequente e intensa em áreas onde as glândulas sebáceas são maiores e mais numerosas, como na face, no tórax e dorso. 6O adapaleno apresenta alta estabilidade frente à luz e ao oxigênio, não demonstrando reatividade química.1,7 Esse fármaco penetra na unidade pilossebácea podendo apresentar alguns efeitos indesejáveis, sendo a irritação e o ressecamento da pele os mais comuns. 4,8,9 Em vista disso, busca-se com o desenvolvimento de sistemas nanoestruturados minimizar esses efeitos adversos e aumentar a eficácia desse ativo direcionando-o ao local de ação.Através desta abordagem nanotecnológica, foram desenvolvidas suspensões contendo nanocápsulas poliméricas de adapaleno utilizando óleo de melaleuca como núcleo oleoso e poli-(ε-caprolactona) como unidade polimérica. No entanto, a extração do fármaco a partir deste sistema nanoestruturado para fins de quantificação é extremamente difícil, sendo necessária a utilização de uma mistura de solventes que possibilite a solubilização da parede polimérica, bem como do ativo.10 Assim sendo, o desenvolvimento de um método simples, rápido e preciso para a extração e quantificação do adapaleno a partir das nanocápsulas é altamente desejável. Em vista disso, o presente trabalho teve como objetivo desenvolver e validar um método analítico para quantificação do adapaleno através de cromatografia líquida de alta eficiência (CLAE).Para garantir que um novo método analítico gere informações confiáveis e interpretáveis sobre a amostra, ele deve passar por um processo de avaliação denominado validação, que garante a confiabilidade e rastreabilidade dos resultados.11 A validação deve garantir, através de estudos experimen...

show abstract

Semisolid Formulation Containing a Nanoencapsulated Sunscreen: Effectiveness, <I>In Vitro</I> Photostability and Immune Response

Cited by 56 publications

References 18 publications

Vegetable oils as core of cationic polymeric nanocapsules: influence on the physicochemical properties

Vegetable oils as core of cationic polymeric nanocapsules: influence on the physicochemical properties

Innovative Sunscreen Formulation Based on Benzophenone-3-Loaded Chitosan-Coated Polymeric Nanocapsules

Validação de método analítico por cromatografia líquida de alta eficiência para doseamento do adapaleno em suspensões de nanocápsulas

Contact Info

Product

Resources

About