Sensing cellular adhesion with a CMOS integrated impedance-to-frequency converter

Mucha, Andreas; Schienle, M.; Schmitt‐Landsiedel, D.

doi:10.1109/sas.2011.5739770

Cited by 12 publications

(5 citation statements)

References 14 publications

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“…Impedance measurements are widespread for the analysis of cell adhesion towards a specific substrate [48,49]. As the cells spread, they alter the effective area available for current flow, causing a decrease in the capacitance as shown in Fig.…”

Section: Results Of Cell Adhesion Measurementsmentioning

confidence: 99%

Monitoring of irritant gas using a whole-cell-based sensor system

Bohrn

Stütz

Fuchs

et al. 2012

Sensors and Actuators B: Chemical

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Cell-based sensors for the detection of gases have long been underrepresented, due to the cellular requirement of being cultured in a liquid environment. In this work we established a cell-based gas biosensor for the detection of toxic substances in air, by adapting a commercial sensor chip (Bionas ® ), previously used for the measurement of pollutants in liquids. Cells of the respiratory tract (A549, RPMI 2650, V79), which survive at a gas phase in a natural context, are used as biological receptors. The physiological cell parameters acidification, respiration and morphology are continuously monitored in parallel. Ammonia was used as a highly water-soluble model gas to test the feasibility of the sensor system. Infrared measurements confirmed the sufficiency of the medium draining method. This sensor system provides a basis for many sensor applications such as environmental monitoring, building technology and public security.

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Section: Results Of Cell Adhesion Measurementsmentioning

confidence: 99%

Monitoring of irritant gas using a whole-cell-based sensor system

Bohrn

Stütz

Fuchs

et al. 2012

Sensors and Actuators B: Chemical

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“…There are many impedance measurement topologies available. Conversion to frequency [93], [94] and using a lock-in amplifier to extract the real and imaginary part of impedance [95]- [97] are among the typical topologies. The measurement principle of the first method is to obtain a frequency proportional to impedance using a periodic bi-directional current across the impedance.…”

Section: Impedance Sensorsmentioning

confidence: 99%

Wearables for the Next Pandemic

Hedayatipour

McFarlane

2020

IEEE Access

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This paper reviews the current state of the art in wearable sensors, including current challenges, that can alleviate the loads on hospitals and medical centers. During the COVID-19 Pandemic in 2020, healthcare systems were overwhelmed by people with mild to severe symptoms needing care. A careful study of pandemics and their symptoms in the past 100 years reveals common traits that should be monitored for managing the health and economic costs. Cheap, low power, and portable multi-modalsensors that detect the common symptoms can be stockpiled and ready for the next pandemic. These sensors include temperature sensors for fever monitoring, pulse oximetry sensors for blood oxygen levels, impedance sensors for thoracic impedance, and other state sensors that can be integrated into a single system and connected to a smartphone or data center. Both research and commercial medically approved devices are reviewed with an emphasis on the electronics required to realize the sensing. The performance characteristics, such as accuracy, power, resolution, and size of each sensor modality are critically examined. A discussion of the characteristics, research challenges, and features of an ideal integrated wearable system is also presented.

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“…The vitality index already stabilizes at a value around 2 after 10 h, while the absolute frequency continues to rise. The used medium was then exchanged for 2 ml of fresh DMEM, which causes a rise of the average frequency [28,29]. The vitality index does not increase as much except one outlier which is a numerical artifact caused by the sudden jump of the absolute frequencies.…”

Section: Impedance Measurements Of Cr Treated Cells 421 Impedance mentioning

confidence: 99%

A critical comparison of cell-based sensor systems for the detection of Cr(VI) in aquatic environment

Bohrn

Mucha

Werner

et al. 2013

Sensors and Actuators B: Chemical

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a b s t r a c tThe toxicity of chromium ions was investigated using mammalian cell cultures on impedance sensors as well as physiological in vitro sensor systems. The performance of commercially available systems like the 2500 Analyzing System (Bionas), xCELLigence (Roche) and Cytosensor Microphysiometer (Molecular Devices) was compared with a novel CMOS-based impedance-to-frequency converter device. Cell-based sensor systems are shown to be powerful tools to detect Cr(VI) pollutions within several hours in the range of multinational drinking water regulations. The ability to distinguish between toxic Cr(VI) and non-toxic Cr(III) species is one advantage of these integral sensor systems. Impedance only devices are not sufficient for the fast detection of toxic chromium species as rapid cellular changes occur only in the respiration system and the cell physiology.

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Sensing cellular adhesion with a CMOS integrated impedance-to-frequency converter

Cited by 12 publications

References 14 publications

Monitoring of irritant gas using a whole-cell-based sensor system

Monitoring of irritant gas using a whole-cell-based sensor system

Wearables for the Next Pandemic

A critical comparison of cell-based sensor systems for the detection of Cr(VI) in aquatic environment

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