Sensing liquid properties with thickness-shear mode resonators

Martin, Stephen J.; Frye, G.C.; Wessendorf, Kurt O.

doi:10.1016/0924-4247(94)00806-x

Cited by 187 publications

(90 citation statements)

References 21 publications

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“…In addition, other groups have reported numerous QCM studies that aim to understand the viscoelastic behavior of macromolecules as a thin film physically adsorbed or chemically conjugated on the QCM substrate [5-8, 11-13, 19-29], or as a viscous liquid remaining on the substrate [30][31][32][33][34]. Recent studies have shown the potential to decouple the mass adsorption-forming thin layer from the fluid viscosity and density [23,35].…”

Section: Introductionmentioning

confidence: 99%

Effect of a Non-Newtonian Load on SignatureS2for Quartz Crystal Microbalance Measurements

2014

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The quartz crystal microbalance (QCM) is increasingly used for monitoring the interfacial interaction between surfaces and macromolecules such as biomaterials, polymers, and metals. Recent QCM applications deal with several types of liquids with various viscous macromolecule compounds, which behave differently from Newtonian liquids. To properly monitor such interactions, it is crucial to understand the influence of the non-Newtonian fluid on the QCM measurement response. As a quantitative indicator of non-Newtonian behavior, we used the quartz resonator signature, 2 , of the QCM measurement response, which has a consistent value for Newtonian fluids. We then modified De Kee's non-Newtonian three-parameter model to apply it to our prediction of 2 values for non-Newtonian liquids. As a model, we chose polyethylene glycol (PEG400) with the titration of its volume concentration in deionized water. As the volume concentration of PEG400 increased, the 2 value decreased, confirming that the modified De Kee's three-parameter model can predict the change in 2 value. Collectively, the findings presented herein enable the application of the quartz resonator signature, 2 , to verify QCM measurement analysis in relation to a wide range of experimental subjects that may exhibit non-Newtonian behavior, including polymers and biomaterials.

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Section: Introductionmentioning

confidence: 99%

Effect of a Non-Newtonian Load on SignatureS2for Quartz Crystal Microbalance Measurements

2014

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“…Piezoelectric devices are highly attractive for biosensor applications due to their high sensitivity and stability [1][2][3][4]. Several materials are used and, up to now, quartz crystal remains the reference material [3][4][5][6] for bulk acoustic wave and surface acoustic wave resonators (QCM) with high stability.…”

Section: Introductionmentioning

confidence: 99%

“…Several materials are used and, up to now, quartz crystal remains the reference material [3][4][5][6] for bulk acoustic wave and surface acoustic wave resonators (QCM) with high stability. High quality quartz crystals can be found easily.…”

Section: Introductionmentioning

confidence: 99%

Design and microfabrication of a lateral excited gallium arsenide biosensor

Bienaime

Liu

Élie-Caille

et al. 2011

Eur. Phys. J. Appl. Phys.

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GaAs crystal presents some interesting perspectives for resonant biosensors due to its piezoelectric and good mechanical properties and the opportunity to bio-functionalize the surface. Moreover, GaAs can be micromachined by wet etching in several solutions, which constitutes a batch and low-cost process of fabrication. The lateral field excitation (LFE) is used to generate bulk acoustic waves. The main advantage of LFE is the possibility to measure in liquid media, but moreover reduced aging and increased frequency stability are also ensured. In this study, an analytical modelisation is used to determine the orientations of the vibrating membrane and the electric field that give satisfactory metrological performances. Electrical performances are discussed as a function of geometrical parameters. A simulation based on a Finite Element Modelisation is performed in order to optimize the design of the resonant structure. The microfabrication process of the structure is presented. The choice of etchants is discussed in terms of etch rates and surface textures. Several steps of the fabrication of the sensing area structure are shown and characterized. Finally, the active area is fabricated according to the theoretical and experimental results of this study.

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“…This approach was used to follow streptavidin binding [16]. While their system permits optical and acoustic detection on a single surface, the surface corrugation will influence the signal measured by the acoustic sensor [8], [17]. Remarkably, the value for the streptavidin layer thickness measured by the acoustic device was lower than expected, a result which could not be unambiguously explained [16].…”

Section: Introductionmentioning

confidence: 99%

Development of a combined surface plasmon resonance/surface acoustic wave device for the characterization of biomolecules

Bender

Roach

Tsortos

et al. 2009

Meas. Sci. Technol.

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It is known that acoustic sensor devices, if operated in liquid phase, are sensitive not just to the mass of the analyte but to various other parameters, such as size, shape, charge and elastic constants of the analyte as well as bound and viscously entrained water. This can be used to extract valuable information about a biomolecule, particularly if the acoustic device is combined with another sensor element which is sensitive to the mass or amount of analyte only. The latter is true in good approximation for various optical sensor techniques. This work reports on the development of a combined surface plasmon resonance / surface acoustic wave sensor system which is designed for the investigation of biomolecules such as proteins or DNA. Results for deposition of neutravidin and DNA are reported.

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Sensing liquid properties with thickness-shear mode resonators

Cited by 187 publications

References 21 publications

Effect of a Non-Newtonian Load on SignatureS2for Quartz Crystal Microbalance Measurements

Effect of a Non-Newtonian Load on SignatureS2for Quartz Crystal Microbalance Measurements

Design and microfabrication of a lateral excited gallium arsenide biosensor

Development of a combined surface plasmon resonance/surface acoustic wave device for the characterization of biomolecules

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