Sensing technologies and experimental platforms for the characterization of advanced oral drug delivery systems

Okeyo, Peter Ouma; Rajendran, Sriram Thoppe; Zór, Kinga; Boisen, Anja

doi:10.1016/j.addr.2021.113850

Cited by 10 publications

(6 citation statements)

References 185 publications

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“…The ability for oral drug delivery devices to be mucoadhesive in the GI tract is crucial as it influences the retention time of the devices as well as the absorption and oral bioavailability of the drugs [4] , [5] , [6] . In general, to characterize mucoadhesion, a flow-through [7] and a tensile strength method [8] have been used to investigate the interaction between a mucus layer and devices.…”

Section: Hardware In Contextmentioning

confidence: 99%

“…The tensile strength method directly measures the mucoadhesion force of a single device, illustrating the mucoadhesion by a force-to-displacement curve [9] . The most widely used instrument for detecting mucoadhesion force is a texture analyzer, which provides force measurements in the range from Newton to milli-Newton [4] , [9] , [10] . However, the mucoadhesive forces of most microdevices are in the micro-Newton range.…”

Section: Hardware In Contextmentioning

confidence: 99%

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Open-source force analyzer with broad sensing range based on an optical pickup unit

et al. 2022

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Section: Hardware In Contextmentioning

confidence: 99%

Section: Hardware In Contextmentioning

confidence: 99%

Open-source force analyzer with broad sensing range based on an optical pickup unit

et al. 2022

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“…Integration of manufacturing techniques is highly desired for developing novel functional materials. − Combining various characterization methods, including advanced ones, is also beneficial as these methods should closely match the scientific problem. , …”

Section: Introductionmentioning

confidence: 99%

3D Printed Drug Delivery Systems in Action–Magnetic Resonance Imaging and Relaxometry for Monitoring Mass Transport Phenomena

Baran,

Birczyński,

Milanowski

et al. 2024

ACS Appl. Mater. Interfaces

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The hypothesis of the study was that (1) 3D printed drug delivery systems (DDS) could be characterized in situ during drug release using NMR/MRI techniques in terms of mass transport phenomena description (interfacial phenomena), particularly for systems dealing with two mobile phases (e.g., water and low molecular weight liquid polymer); (2) consequently, it could be possible to deduce how these interfacial mass transport phenomena influence functional properties of 3D printed DDS. Matrix drug delivery systems, prepared using masked stereolithography (MSLA), containing poly(ethylene glycol) diacrylate (PEGDA) and low molecular weight polyethylene glycol (PEG) with ropinirole hydrochloride (RH) were studied as example formulations. The PEGDA to PEG (mobile phase) concentration ratio influenced drug release. It was reflected in spatiotemporal changes in parametric T 2 relaxation time (T 2 ) and amplitude (A) images obtained using magnetic resonance imaging (MRI) and T 1 -T 2 relaxation time correlations obtained using low-field time-domain nuclear magnetic resonance (LF TD NMR) relaxometry during incubation in water. For most of the tested formulations, two signal components related to PEG and water were assessed in the hydrated matrices by MRI relaxometry (parametric T 2 /A images). The PEG component faded out due to outward PEG diffusion and was gradually replaced by the water component. Both components spatially and temporally changed their parameters, reflecting evolving water−polymer interactions.The study shows that dynamic phenomena related to bidirectional mass transport can be quantified in situ using NMR and MRI techniques to gain insight into drug release mechanisms from 3D printed DDS systems.

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“…Improved understanding of disease mechanisms and advances in medical technology have made it evident that accurate delivery of therapeutic agents to their target sites in a safe and timely manner is the basis for achieving precise and controlled therapies 1–8 . To alleviate drug‐induced side effects and improve the quality of life, researchers across disciplines are developing new therapeutic agents, 9–14 constructing novel nano‐drug systems, 15–18 screening new drug targets, 19–21 and exploring new disease diagnosis methods 22–24 .…”

Section: Introductionmentioning

confidence: 99%

Dynamic responsiveness of self‐assembling peptide‐based nano‐drug systems

Wang

Zhan

Huang

et al. 2023

Interdisciplinary Medicine

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Dynamic‐responsive self‐assembly is the process of ordered supramolecular structure formation or reversible decomposition from building blocks. This process is driven by non‐covalent interactions based on complex stimulus‐responsive systems comprising different components within a microenvironment. Furthermore, stimuli‐responsive assembly‐disassembly is an intrinsic interaction process in organisms, indispensable in maintaining life activities and functions. However, the dynamic interactions between dynamically responsive nano‐drug systems (DRNSs) and biological systems remain unpredictable, which are a challenge for the precisely targeted therapy and controlled drug release of DRNSs in vivo. This review highlights novel self‐assembling peptide‐based nano‐drug systems and their biological interactions. By precisely controlling the shape and size of self‐assembled peptide nanomaterials, biologically simulated components with diverse biological functions and precise transport at the subcellular level can be achieved. We have also summarized the limitations and challenges of responsive self‐assembling peptide nanomaterials in clinical translation. Additionally, we have discussed the future perspectives of supramolecular therapeutics using signaling molecule gradient concentrations and efficiencies and highlighted the direction for developing clinically translatable smart nanomedicines.

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Sensing technologies and experimental platforms for the characterization of advanced oral drug delivery systems

Cited by 10 publications

References 185 publications

Open-source force analyzer with broad sensing range based on an optical pickup unit

Open-source force analyzer with broad sensing range based on an optical pickup unit

3D Printed Drug Delivery Systems in Action–Magnetic Resonance Imaging and Relaxometry for Monitoring Mass Transport Phenomena

Dynamic responsiveness of self‐assembling peptide‐based nano‐drug systems

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