Sensing the scent of death: Modulation of microRNAs by Curcumin in gastrointestinal cancers

Ashrafizadeh, Milad; Zarrabi, Ali; Hashemipour, Maryam Alsadat; Vosough, Massoud; Najafi, Masoud; Shahinozzaman, Muhammad; Hushmandi, Kiavash; Khan, Haroon; Mirzaei, Hamed

doi:10.1016/j.phrs.2020.105199

Cited by 71 publications

(36 citation statements)

References 229 publications

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“…Curcumin or [(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione] is a polyphenolic extraction of Curcuma longa species, which is often termed as turmeric ( Shafabakhsh et al, 2019 ; Ashrafizadeh et al, 2020 ). Curcumin had been used as a traditional Ayurvedic medicine due to its significant anti-inflammatory ( Satoskar et al, 1986 ), antioxidant ( Masuda et al, 2001 ), and antimicrobial ( Negi et al, 1999 ) properties.…”

Section: Introductionmentioning

confidence: 99%

Antimetastatic Effects of Curcumin in Oral and Gastrointestinal Cancers

Davoodvandi

Farshadi²,

Zare

et al. 2021

Front. Pharmacol.

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Gastrointestinal (GI) cancers are known as frequently occurred solid malignant tumors that can cause the high rate mortality in the world. Metastasis is a significant destructive feature of tumoral cells, which directly correlates with decreased prognosis and survival. Curcumin, which is found in turmeric, has been identified as a potent therapeutic natural bioactive compound (Curcuma longa). It has been traditionally applied for centuries to treat different diseases, and it has shown efficacy for its anticancer properties. Numerous studies have revealed that curcumin inhibits migration and metastasis of GI cancer cells by modulating various genes and proteins, i.e., growth factors, inflammatory cytokines and their receptors, different types of enzymes, caspases, cell adhesion molecules, and cell cycle proteins. Herein, we summarized the antimetastatic effects of curcumin in GI cancers, including pancreatic cancer, gastric cancer, colorectal cancer, oral cancer, and esophageal cancer.

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Section: Introductionmentioning

confidence: 99%

Antimetastatic Effects of Curcumin in Oral and Gastrointestinal Cancers

Davoodvandi

Farshadi²,

Zare

et al. 2021

Front. Pharmacol.

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“…Curcumin can induce apoptosis in cancer cells via activating caspase cascade and upregulating caspase-3 expression [293]. It has been reported that curcumin can regulate miRNA expression in cancer therapy [294][295][296]. Upon curcumin administration, the expression level of tumor-promoting miRNAs including miRNA-21 and miRNA-27a undergoes downregulation, while an increase occurs in the expression of tumor-suppressing miRNAs such as miRNA-22 and miRNA-145 [297].…”

Section: Lung Cancermentioning

confidence: 99%

Small in Size, but Large in Action: microRNAs as Potential Modulators of PTEN in Breast and Lung Cancers

et al. 2021

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MicroRNAs (miRNAs) are well-known regulators of biological mechanisms with a small size of 19–24 nucleotides and a single-stranded structure. miRNA dysregulation occurs in cancer progression. miRNAs can function as tumor-suppressing or tumor-promoting factors in cancer via regulating molecular pathways. Breast and lung cancers are two malignant thoracic tumors in which the abnormal expression of miRNAs plays a significant role in their development. Phosphatase and tensin homolog (PTEN) is a tumor-suppressor factor that is capable of suppressing the growth, viability, and metastasis of cancer cells via downregulating phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling. PTEN downregulation occurs in lung and breast cancers to promote PI3K/Akt expression, leading to uncontrolled proliferation, metastasis, and their resistance to chemotherapy and radiotherapy. miRNAs as upstream mediators of PTEN can dually induce/inhibit PTEN signaling in affecting the malignant behavior of lung and breast cancer cells. Furthermore, long non-coding RNAs and circular RNAs can regulate the miRNA/PTEN axis in lung and breast cancer cells. It seems that anti-tumor compounds such as baicalein, propofol, and curcumin can induce PTEN upregulation by affecting miRNAs in suppressing breast and lung cancer progression. These topics are discussed in the current review with a focus on molecular pathways.

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“…Symptoms of this disease do not become apparent until the advanced stage of disease. In recent decades, a continuous decrease in the incidence rates of GC has been found worldwide [ 4 , 5 , 6 , 7 ], as the decrease in GC rate may be related to the improvement of hygiene and food standards and the eradication of Helicobacter pylori ( H. pylori ) [ 8 ]. Genetic background, environmental pollutants, cigarette smoking, alcohol consumption, socioeconomic status, and H. pylori infection are known to be the main risk factors for GC [ 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Roles of Nrf2 in Gastric Cancer: Targeting for Therapeutic Strategies

et al. 2021

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Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) is a specific transcription factor with potent effects on the regulation of antioxidant gene expression that modulates cell hemostasis under various conditions in tissues. However, the effects of Nrf2 on gastric cancer (GC) are not fully elucidated and understood. Evidence suggests that uncontrolled Nrf2 expression and activation has been observed more frequently in malignant tumors, including GC cells, which is then associated with increased antioxidant capacity, chemoresistance, and poor clinical prognosis. Moreover, Nrf2 inhibitors and the associated modulation of tumor cell redox balance have shown that Nrf2 also has beneficial effects on the therapy of various cancers, including GC. Based on previous findings on the important role of Nrf2 in GC therapy, it is of great interest to scientists in basic and clinical tumor research that Nrf2 can be active as both an oncogene and a tumor suppressor depending on different background situations.

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Sensing the scent of death: Modulation of microRNAs by Curcumin in gastrointestinal cancers

Cited by 71 publications

References 229 publications

Antimetastatic Effects of Curcumin in Oral and Gastrointestinal Cancers

Antimetastatic Effects of Curcumin in Oral and Gastrointestinal Cancers

Small in Size, but Large in Action: microRNAs as Potential Modulators of PTEN in Breast and Lung Cancers

Roles of Nrf2 in Gastric Cancer: Targeting for Therapeutic Strategies

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