Sensitive adsorptive stripping voltammetric procedure of Imatinib determination in spiked urine samples using solid lead microelectrode

Abstract

This article reports for the first time the application of solid lead microelectrode for organic compound determination. The proposed sensor was used for anticancer drug Imatinib quantification by adsorptive stripping voltammetry. Procedure of Imatinib determination was developed utilizing advantages ensured by solid lead microelectrode: reusability and durability for a long period of time and its ecological character as compared to film electrodes. The detection limit of Imatinib determination was calculated to be 1.9 × 10 À 10 mol L À 1 . The analytical usability of the developed procedure was confirmed by acceptable recoveries of Imatinib determination in spiked urine samples.