Sensitive and selective determination of tolterodine tartrate and its electrochemical investigation on solid carbon based electrodes

Abstract

9701 Tolterodine tartrate (TLT) is a muscarinic receptor antagonist which is used for the treatment of urinary incontinence. It has a good selectivity for the muscar inic receptors for the overactive bladder. TLT helps preferably geriatric population to control urinary fre quency, urgency, and incontinence in detrusor insta bility. Tolterodine tartrate works on the lower urinary tract by increasing the residual urine and decreasing detrusor pressure [1,2].After oral administration, TLT is metabolised in the liver forming 5 hydroxymethyl derivative. This ac tive metabolite and tolterodine having similar anti muscarinic activity exhibit high specificity for musca rinic receptors, since they show clinically insignificant effects on other neurotransmitter receptors and other pharmacological targets such as calcium channels [3].TLT has fewer side effects than the other antimus carinic drugs such as oxybutynin, since it effectively targets the bladder and is tolerated better [4]. Thus, the patients need less drug and gain less side effects such as dizziness, abdominal pain, and headache [5,6]. The 1 The article is published in the original. chemical name of TLT with an empirical formula as C 26 H 37 NO 7 is (R) N,N diisopropyl 3 (2 hydroxy 5 methylphenyl) 3 phenylpropanamine L hydrogen tartrate (Structure I in Fig. 1).TLT has been studied and determined using a few analytical methods: HPLC -electrospray ionization mass spectrometric determination in human plasma [7], HPLC for the enantiometric separation of TLT [8], LC -tandem mass spectrometry in human plas ma [9], gas chromatography -mass spectrometry in plasma, serum, and urine [10], capillary solid phase extraction -tandem mass spectrometry in plasma samples [11], capillary liquid chromatography -tan dem mass spectrometry in plasma [12]. These reported methods require more expensive instrumentation and relatively high running costs. There has been no infor mation on the electrochemical behavior of TLT and its determination using any voltammetric techniques re ported in the literature. Electroanalytical methods of fer simple, sensitive, cheap, and fast measurements for the determination of a wide range of drug active com pounds. Moreover, it is important to investigate the electrochemical properties of the drugs, since meta Abstract-Tolterodine tartrate, a muscarinic receptor antagonist, was oxidized in various buffer media with different pH values using cyclic, differential pulse, and square wave voltammetric techniques on glassy carbon and boron doped diamond electrodes. Two irreversible anodic peaks were obtained. The oxidation process of tolterodine tartrate was diffusion controlled depending on pH for both electrodes. A detailed oxidation mech anism was proposed and discussed. The dependences of the peak current and peak potentials on pH, concen tration, nature of the buffer, and scan rate were investigated. A linear response between the peak current and the tolterodine tartrate concentration was obtained using differential pulse and square wave voltammetric te...

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