Sensitive and selective electrochemical determination of doxycycline in pharmaceutical formulations using poly(dipicrylamine) modified glassy carbon electrode

Gashu, Mulu; Kassa, Adane; Tefera, Molla; Amare, Meareg; Aragaw, Belete Asefa

doi:10.1016/j.sbsr.2022.100507

Cited by 10 publications

(2 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, spectrophotometric methods are promising and flexible analytical techniques that are quick, have a low limit of detection (LOD), need little analysis time, have excellent sensitivity and selectivity, and require few expensive instruments to determine analytes. [10,11] Only a few studies have been published on the electrochemical determination of doxycycline hyclate in pharmaceutical samples using molecularly imprinted electrochemical sensors based on modified glassy carbon electrodes made of multi-walled carbon nanotubes (MWCNTs), [12] molecularly imprinted gold electrodes (MIP/AuE), [13] DNA-immobilized onto carbon nanotube paste electrodes (CNTP), [14] and gold nanoparticles embedded molecularly imprinted polymer modified carbon paste composite electrode. The majority of these sensors need the usage of pricy materials like gold nanoparticles that must be prepared using difficult techniques.…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of Spectrophotometric Methods for the Quantitative Determination of Doxycycline Hyclate in Pure Form and Pharmaceutical Formulations Using Flow‐Injection and Batch procedures: A Comparative Study

Abdulghani

Hassan

2023

ChemistrySelect

View full text Add to dashboard Cite

Doxycycline hyclate is an antibiotic drug with a broad‐spectrum activity against a variety of gram‐positive and gram‐negative bacteria and is frequently used as a pharmacological agent and as an effector molecule in an inducible gene expression system. A sensitive, reliable and fast spectrophotometric method for the determination of doxycycline hyclate in pure and pharmaceutical formulations has been developed using flow injection analysis (FIA) and batch procedures. The proposed method is based on the reaction between the chromogenic reagent (V4+) and doxycycline hyclate in a neutral medium, resulting in the formation of a yellow compound that shows maximum absorbance at 396 nm. In a batch procedure, the proposed method was validated over the concentration range of 1.0–80 μg mL−1 with a sampling frequency of 30/h, and commercial pharmaceutical samples were successfully determined. The proposed method was successfully adapted with an FIA system where the peak heights are proportionally connected to doxycycline hyclate over the concentration range of 25–400 μg mL−1 with a sampling frequency of 50/h. The limits of detection (LOD) and quantification (LOQ) were 0.9 and 10.44 μg mL−1 and 3.01 and 34.81 μg mL−1 for batch and FIA respectively. The samples were submitted to an HPLC analysis, and the outcomes demonstrated excellent agreement with the suggested procedures. The adopted FIA procedure allows fast monitoring of doxycycline hyclate in pharmaceutical formulations and it can be used for quality control purposes during the production processes of doxycycline hyclate.

show abstract

Section: Introductionmentioning

confidence: 99%

Development and Validation of Spectrophotometric Methods for the Quantitative Determination of Doxycycline Hyclate in Pure Form and Pharmaceutical Formulations Using Flow‐Injection and Batch procedures: A Comparative Study

Abdulghani

Hassan

2023

ChemistrySelect

View full text Add to dashboard Cite

show abstract

“…The oxidation process of the voltammetric behavior of Doxy has been described in several studies. In general, two oxidation peaks are observed, the first being due to the dimethylamino group in position 4, and the second to the phenolic group in position 10 [ 34 , 35 ]. Studies have shown that increasing the pH decreases the peak current intensity, which is characteristic of the phenolic group in the 10-position of tetracyclines [ 36 , 37 ].…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Real-Time Release of Doxycycline from PLA-Based Nanofibers

Farkas

Marincaș

Barbu–Tudoran

et al. 2023

JFB

View full text Add to dashboard Cite

Electrospun mats of PLA and PLA/Hap nanofibers produced by electrospinning were loaded with doxycycline (Doxy) through physical adsorption from a solution with initial concentrations of 3 g/L, 7 g/L, and 12 g/L, respectively. The morphological characterization of the produced material was performed using scanning electron microscopy (SEM). The release profiles of Doxy were studied in situ using the differential pulse voltammetry (DPV) electrochemical method on a glassy carbon electrode (GCE) and validated through UV-VIS spectrophotometric measurements. The DPV method has been shown to be a simple, rapid, and advantageous analytical technique for real-time measurements, allowing accurate kinetics to be established. The kinetics of the release profiles were compared using model-dependent and model-independent analyses. The diffusion-controlled mechanism of Doxy release from both types of fibers was confirmed by a good fit to the Korsmeyer–Peppas model.

show abstract

Unconventional Fluorescent and Multi-responsive Polysiloxane: Synthesis, Characterization and Biological Applications

Li,

Jiang

et al. 2024

Chin J Polym Sci

View full text Add to dashboard Cite

Sensitive and selective electrochemical determination of doxycycline in pharmaceutical formulations using poly(dipicrylamine) modified glassy carbon electrode

Cited by 10 publications

References 52 publications

Development and Validation of Spectrophotometric Methods for the Quantitative Determination of Doxycycline Hyclate in Pure Form and Pharmaceutical Formulations Using Flow‐Injection and Batch procedures: A Comparative Study

Development and Validation of Spectrophotometric Methods for the Quantitative Determination of Doxycycline Hyclate in Pure Form and Pharmaceutical Formulations Using Flow‐Injection and Batch procedures: A Comparative Study

Investigation of the Real-Time Release of Doxycycline from PLA-Based Nanofibers

Unconventional Fluorescent and Multi-responsive Polysiloxane: Synthesis, Characterization and Biological Applications

Contact Info

Product

Resources

About