Sensitive and Selective Electrochemical Determination of L‐Cysteine Based on Cerium Oxide Nanofibers Modified Screen Printed Carbon Electrode

Abstract

A novel L‐cysteine (CysH) electrochemical sensor based on CeO2 nanofibers (NFs) modified screen printed carbon electrodes (SPCEs) was developed. The morphology and the structure of the as‐prepared CeO2 NFs were first characterized using scanning electron microscopy (SEM) and X‐ray diffraction pattern (XRD), respectively. The electrochemical and electrocatalytic performances of the CeO2 NFs modified SPCEs were then evaluated using cyclic voltammetry and amperometry. Experimental results showed that the CeO2 NFs modified SPCEs possess excellent electrocatalytic activity toward the detection of CysH. Specifically, the developed electrochemical sensor demonstrated a high sensitivity of 120 μA mM−1 cm−2, a low detection limit of 20 nM (signal to noise ratio of 3) and a wide linear range up to 200 μM for the determination of CysH, which are among the best values reported in literature. In addition, good selectivity and outstanding intra‐ and inter‐electrode reproducibility have also been observed. Furthermore, the developed CysH sensor was applied to detect CysH spiked into human serum samples with remarkable accuracy. All these features indicate that CeO2 NFs hold great promise in the development of high performance electrochemical sensor for CysH.

Electrochemical Amino Acid Sensing: A Review on Challenges and Achievements

“…Noble metals, e.g., gold [ 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 ], palladium [ 67 ], platinum [ 67 ], silver [ 68 , 69 , 70 ], noble metal composites, e.g., gold/copper [ 71 ], gold/silver [ 72 ], gold/nickel [ 73 ], gold/platinum [ 74 ] and silver/palladium [ 75 ], have been extensively used. Additionally, metal oxides, e.g., CeO 2 [ 76 ], Cu (X) O [ 77 ], Fe 2 O 3 [ 78 ], MgO [ 79 ], MnO 2 [ 80 ], NiO [ 81 ], SnO 2 [ 82 ], TiO 2 [ 83 ], WO 3 [ 84 ], Y 2 O 3 [ 85 ] and ZnO [ 86 ], as well as organic modifiers [ 87 , 88 , 89 , 90 , 91 , 92 , 93 , …”

A comprehensive review on recent trends in amino acids detection through analytical techniques

“…Using XRD and scanning electron microscopy (SEM), respectively, the morphology and structure of the as-prepared CeO2 NFs were analyzed. The designed sensor demonstrated good electrocatalytic oxidation for the detection of L-Cys [43].…”

Recent developments in voltammetric and amperometric sensors for cysteine detection

“…Cao et al also devised an l -Cys electrochemical sensor based on CeO 2 nanofibers modified screen printed carbon electrodes (SPCEs). 111 The electrochemical, as well as the electrocatalytic, functions of the CeO 2 nano-fibers modified SPCEs were assessed with the use of CV and amperometry. According to the experimental outputs, the CeO 2 nano-fibers modified SPCEs had very good electrocatalytic activities towards l -Cys detection.…”