Sensitive and selective spectrophotometric assay of piroxicam in pure form, capsule and human blood serum samples via ion-pair complex formation

Voltammetric Evaluation of Diclofenac Tablets Samples through Carbon Black-Based Electrodes

“…Inflammatory diseases constitute a complex and heterogeneous group of diseases, which are an important cause of disability. The pharmacological treatment of such diseases is mostly based on the use of corticosteroids and non-steroidal anti-inflammatory drugs (NSAIDs) [1,2,3]. Diclofenac (DIC) is a non-selective cyclooxygenase inhibitor belonging to NSAIDs, which acts by inhibiting the synthesis of prostaglandins that have a wide capacity to induce inflammation [1].…”

“…Pharmacopoeial methods for DIC assessment are often based in high-performance liquid chromatography (HPLC) [2,3,4], however, such techniques involve a number of pre-preparative steps, elevated cost of laboratory equipment, and are reagent-consuming methods. Although methods such as titulometry and spectrophotometry are also largely applied for DIC assessment to avoid costly methods, they lack nevertheless suitable precision and accuracy [4,5,6].…”

Association of 5,5′-Dibromo-o-Cresolsulfonphthalein Anions with Dye Cations in Aqueous Solution

“…[11][12][13][14][15] One of the most common areas of application is the use of bromine derivatives as analytical reagents, including the determination of components in biosamples and pharmaceuticals: antiviral, 16 antiseptic, 17,18 bactericidal, [19][20][21] antitumor, 22 antihypertensive, 23 antitussives 24,25 and others. [26][27][28][29] The effective use of 5,5′-dibromo-o-cresolsulfonphthalein (DBS) in the technologies of recent years is known. These include sensitive electrochemical DNA biosensors to the antitumor drug; 31 highly efficient extraction of heavy metals from industrial effluents by adsorption on a modified zeolite surface; 32 lysine decarboxylase analysis, 33 adsorption of hydrophobic molecules on the membrane of erythroleukemia cells; 34 evaluation of the properties of serum albumin, 30,[35][36][37][38][39][40][41] extracellular lactase.…”

“…42 It is noteworthy that many applications are based on the formation of ion pairs (associates) between the anionic form of sulfonphthalein and the analyte . 5,10,[17][18][19][20][21][22][23][24][25][26][27][28][29] In some cases, such associates can be extracted from the aqueous to organic phases. 17,22,27 Analysis of publications indicates the need for indepth study of cation-anionic interactions that cause the formation of associates, which include anions (HAn -, An 2-) of DBS.…”