Sensitive assay for the determination of cefazolin or ceftriaxone in plasma utilizing LC

Al‐Rawithi, Sameer; Hussein, Rajaa Farhan; Raines, Dale A.; Alshowaier, Ibrahim A.; Kurdi, Wesam

doi:10.1016/s0731-7085(99)00273-3

Cited by 39 publications

(27 citation statements)

References 11 publications

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“…It was considered that no apparent interference occurred if the relative error caused by foreign material was less than ±5%. The results showed that no apparent interference was found when including up to a 500-fold K + , Na + , NH4 + , Cl -, SO4 2 …”

Section: Interferencesmentioning

confidence: 97%

“…According to published literature, the various chromatographic methods, including conventional LC, HPLC and HPTLC, have been proposed for the detection of ceftriaxone sodium in pharmaceuticals or in body fluids, respectively. [1][2][3][4] Other analytical procedures, such as fluorometric and spectrophotometric determinations, were reported. [5][6][7] Due to its inherent high sensitivity and low detection limit, CL has been extensively applied in pharmaceuticals analysis.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Determination of Ceftriaxone Sodium in Pharmaceutical Formulations by Flow Injection Analysis with Acid Potassium Permanganate Chemiluminescence Detection

Zhang

Zhou

et al. 2006

ANAL. SCI.

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Section: Interferencesmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Determination of Ceftriaxone Sodium in Pharmaceutical Formulations by Flow Injection Analysis with Acid Potassium Permanganate Chemiluminescence Detection

Zhang

Zhou

et al. 2006

ANAL. SCI.

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“…10 Cefazolin sodium has some analytical methods described in official compendia such as British, 11 European, 12 Japanese, 13 Portuguese 14 and US 15 pharmacopeias. In the literature, several methods have been described for the qualitative 16 and quantitative analysis of cefazolin sodium, included spectrophotometry, [17][18][19][20][21][22][23][24][25][26][27][28][29] high-performance liquid chromatography [30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47] and voltammetry. 48 However, most of them were time-consuming and dedicated to sophisticated and expensive analytical instruments.…”

Section: Introductionmentioning

confidence: 99%

New Environmentally Friendly Method for Quantification of Cefazolin Sodium

Rechelo¹,

Fernandes²,

Kogawa³

et al. 2017

ECB

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Cefazolin sodium, a β-lactam antimicrobial agent belonging to the first generation cephalosporins, has a broad spectrum of action, acting against gram positive and gram negative bacteria. Stands out over other cephalosporins for its ability to also act against some species of Enterobacter, and have a long half-life, thus reducing the frequency of administrations. A simple, fast and reproducible method by visible spectrophotometry was developed and validated for quantification of cefazolin sodium in the lyophilized powder. This technique is widely used in the pharmaceutical industry due to its ease of execution, low cost, safety and high precision and accuracy. It has been employed in the quality control routine of numerous pharmaceuticals in order to identify them and quantify their active principles. The method was capable of detecting and quantifying the cefazolin sodium obtaining satisfactory results regarding selectivity, precision, accuracy and robustness, on linear range of 32.0 to 92.0 µg mL -1 , showing the correlation coefficient of 0.9993 when analyzed at 767 nm. Due to the environmental impacts caused by global economic development, green chemistry has come up with a proposal to minimize and/or eliminate the use of harmful solvents, which generate large amounts of toxic waste to the environment and the health of operators, as well as reducing expenses with costly processes. The proposed method does not use toxic solvent, proving to be effective, low cost, easy to apply and safe for the analyst and environment. *Corresponding AuthorsFax: +55 16 3301 6967 E-Mail: ac_kogawa@yahoo.com.br [a]

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“…A literature search indicates that HPLC has been used to analyze cefazolin sodium alone 26 and in combination with other drugs often coadministered. 27,28 However, there have been few stability studies of cefazolin sodium using HPLC.…”

Section: Introductionmentioning

confidence: 99%

Novel HPLC method for quantitative determination of cefazolin sodium in pharmaceutical formulations

Hasan¹,

Sher²,

Siddiqui³

et al. 2013

RRMC

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This paper reports a validated high-performance liquid chromatography method which is rapid, highly specific, and accurate for determination of cefazolin sodium in injectable pharmaceutical formulations. Separation was carried out using a Hibar ® µBondapak ® C 18 column with a mobile phase consisting of an acetonitrile to monobasic sodium phosphate buffer ratio of 17:83 and a flow rate of 1.0 mL per minute, and monitoring at a wavelength of 254 nm. The calibration curve was linear, with a correlation coefficient .0.9995 in the range of 5-100 µg/mL. Drug recovery was 98.35%-100.86%, with a limit of detection of 12.92 ng/mL and a limit of quantification of 43.09 ng/mL. The drug was subjected to stress conditions of hydrolysis (acid, base, oxidation, and thermal degradation), where maximum degradation was observed. Forced degradation studies confirmed stability indicating power of this method, which was validated in accordance with International Conference on Harmonization guidelines and used successfully to quantify the amounts of cefazolin sodium in bulk injectable formulations and in physiological fluid.

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Sensitive assay for the determination of cefazolin or ceftriaxone in plasma utilizing LC

Cited by 39 publications

References 11 publications

Determination of Ceftriaxone Sodium in Pharmaceutical Formulations by Flow Injection Analysis with Acid Potassium Permanganate Chemiluminescence Detection

Determination of Ceftriaxone Sodium in Pharmaceutical Formulations by Flow Injection Analysis with Acid Potassium Permanganate Chemiluminescence Detection

New Environmentally Friendly Method for Quantification of Cefazolin Sodium

Novel HPLC method for quantitative determination of cefazolin sodium in pharmaceutical formulations

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