Sensitive distance-based paper-based quantification of mercury ions using carbon nanodots and heating-based preconcentration

Ninwong, Benjawan; Sangkaew, Prapaporn; Hapa, Photcharapan; Ratnarathorn, Nalin; Menger, Ruth F.; Henry, Charles S.; Dungchai, Wijitar

doi:10.1039/d0ra00791a

Cited by 41 publications

(29 citation statements)

References 49 publications

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“…As a sensing platform, the detection limit of 10.7 nM for Hg(II) detection was achieved based on the quenching effect. A paper-based fluorescence sensor with instrument-free signal quantitation was developed for selective detection of Hg(II) by Henry et al [124]. The quantitation results were obtained by calculating the quenching distance on the filter paper after the addition of Hg(II) by simple measurement with a ruler.…”

Section: Paper-based Devicesmentioning

confidence: 99%

Recent advances in fluorescence probes based on carbon dots for sensing and speciation of heavy metals

2020

Nanophotonics

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Heavy metal (HM) pollution is a major global concern. Carbon dots (CDs) have demonstrated unique properties as sensing platforms for HMs detection. This review summarizes the progress made in recent years in fluorescence methods to determine HMs and their species using CDs. First, the strategies to synthesize and purify CDs are reviewed. The photoluminescence principles of CDs and their sensing mechanisms as HMs sensors are then summarized. The binding strategies between CDs and HMs are proposed to provide salient principles to design desirable CD-based HMs sensors. The preparation and merits of “turn-on” and ratiometric CDs for HMs detection with higher accuracy are discussed compared with commonly used “turn-off” sensors. Subsequently, the progress on detecting single HM ions, multi-HMs, and different metal species in solution, and the development of gel/solid-state sensor platforms such as paper-based devices, sensor arrays, hydrogels, polymer films, and ion-imprinted polymers are critically accessed. Furthermore, the advances in the cell, bacterial, plant, and animal bioimaging of HMs with CDs as promising bioimaging reagents are presented. Finally, the challenges and prospects of CDs as HMs sensors in future investigations are discussed.

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Section: Paper-based Devicesmentioning

confidence: 99%

Recent advances in fluorescence probes based on carbon dots for sensing and speciation of heavy metals

2020

Nanophotonics

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“…More specifically, carbon dots (CDs) possess many advantageous properties to serve as metal nanosensors, including their chemical versatility, hydrophilicity, photostability and low chemical and cytotoxicity [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ]. Previous works have evidenced excellent CD sensitivity in detecting metals such as Hg 2+ [ 19 , 20 , 21 , 22 , 23 , 24 ], Fe 3+ [ 25 , 26 ] and Pb 2+ [ 27 , 28 ], among others [ 13 , 29 , 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

Elucidating the Quenching Mechanism in Carbon Dot-Metal Interactions–Designing Sensitive and Selective Optical Probes

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Naccache

2021

Sensors

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Overexposure to metals has significant adverse effects on human and animal health coupled with nefarious consequences to the environment. Sensitive tools to measure low contaminant levels exist, but often come at a high cost and require tedious procedures. Thus, there exists a need for the development of affordable metal sensors that can offer high sensitivity and selectivity while being accessible on a global scale. Here, carbon dots, prepared in a one-pot synthesis using glutathione and formamide, have been developed as dual fluorescent metal sensing probes. Following extensive characterization of their physico-chemical properties, it is demonstrated that dual fluorescence can be exploited to build a robust ratiometric sensor with low-ppb detection sensitivity in water. This investigation shows that these optical probes are selective for Pb2+ and Hg2+ ions. Using steady-state and dynamic optical characterization techniques, coupled with hard and soft acid-base theory, the underlying reason for this selective behavior was identified. These findings shed light on the nature of metal-carbon dot interactions, which can be used to tailor their properties to target specific metal ions. Finally, these findings can be applicable to other fluorescent nanoparticle systems that are targeted for development as metal sensors.

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“…The distance-based approach can also be performed on a cotton thread substrate, which is an alternative material to paper for the fabrication of the fluidic sensor for the analysis of environmental contaminants [ 21 , 22 ]. In addition, by combination with a pre-concentration approach, such as headspace microextraction [ 23 ], solid-phase extraction [ 24 ], and a portable heater [ 25 ], the sensitivity of measurements can be improved. Furthermore, there are several reports of using distance-based applications for clinical diagnosis such as chloride test [ 26 ], potassium [ 27 ], alkaline phosphatase [ 28 ], and cardiac troponin I [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

“…For the detection of metal ions, the dPADs have also been previously reported using the principle based on the deposition of chemical chelating compounds, such as dithizone [ 30 ] and a synthesized porphyrin [ 31 ]. Interestingly, the growing interest in dPAD application is reflected by the increasing number of publications during recent years, by using several strategies such as G-quadruplex-DNAzyme [ 32 ], starch hydrolysis [ 33 ], ionophore-doped ion-selective nanospheres [ 34 , 35 ], and synthesized fluorescent ligands [ 25 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

A Simple Distance Paper-Based Analytical Device for the Screening of Lead in Food Matrices

et al. 2021

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A simple and rapid distance paper-based analytical device (dPAD) for the detection of lead (Pb) in foods is proposed herein. The assay principle is based on competitive binding between carminic acid (CA) and polyethyleneimine (PEI) to Pb in a food sample. The paper channels were pre-immobilized with PEI, before reacting with a mixture of the sample and CA. Pb can strongly bind to the CA; hence, the length of the red color deposition on the flow channel decreased as a lower amount of free CA bound to PEI. The dPAD exhibited good linear correlation, with ranges of 5–100 µg·mL−1 (R2 = 0.974) of Pb. Although, the limit of detection (LOD) of this platform was rather high, at 12.3 µg·mL−1, a series of standard additions (8.0, 9.0, and 10.0 µg·mL−1) can be used to interpret the cutoff of Pb concentrations at higher or lower than 2 µg·mL−1. The presence of common metal ions such as calcium, magnesium, nickel, and zinc did not interfere with the color distance readout. The validity of the developed dPAD was demonstrated by its applicability to screen the contamination of Pb in century egg samples. The results obtained from the dPAD are in accordance with the concentration measured by atomic absorption spectroscopy (AAS) (n = 9). In conclusion, this proposed dPAD, combined with the standard addition method, could be applied for screening Pb contamination in food matrices. This platform is, therefore, potentially applicable for field measurements of Pb in developing countries, because it is cheap and rapid, and it requires no significant laborious instruments.

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Sensitive distance-based paper-based quantification of mercury ions using carbon nanodots and heating-based preconcentration

Abstract: This article reports the first fluorescent distance-based paper device coupled with an evaporating preconcentration system for determining trace mercury ions (Hg2+) in water.

Cited by 41 publications

References 49 publications

Recent advances in fluorescence probes based on carbon dots for sensing and speciation of heavy metals

Recent advances in fluorescence probes based on carbon dots for sensing and speciation of heavy metals

Elucidating the Quenching Mechanism in Carbon Dot-Metal Interactions–Designing Sensitive and Selective Optical Probes

A Simple Distance Paper-Based Analytical Device for the Screening of Lead in Food Matrices

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