Sensitive screening of methamphetamine stimulant using potential-modulated electrochemiluminescence

Takahashi, Fumiki; Nitta, Saki; Shimizu, Ryo; Shoji, Taku; Tatsumi, Hirosuke; Jin, Jiye

doi:10.1016/j.aca.2021.339229

Cited by 7 publications

(2 citation statements)

References 29 publications

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“…We previously developed a sensitive ECL analysis method using the PM technique, 37,43) and applied PM-ECL to the sensitive determination of codeine. An alternating potential is superimposed on a direct current, and the alternating component of the observed ECL response is detected under PM-ECL measurement.…”

Section: Pm-ecl Behavior Of the [Ru(bpy) 3 ] 2+ /Codeine Systemmentioning

confidence: 99%

Development of a Potential-Modulated Electrochemiluminescence Measurement System for Selective and Sensitive Determination of the Controlled Drug Codeine

Takahashi,

Shimosaka,

Mori

et al. 2024

Chem. Pharm. Bull.

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Codeine is a common analgesic drug that is a pro-drug of morphine. It also has a high risk of abuse as a recreational drug because of its extensive distribution as an OTC drug. Therefore, sensitive and selective screening methods for codeine are crucial in forensic analytical chemistry. To date, a commercial analytical kit has not been developed for dedicated codeine determination, and there is a need for an analytical method to quantify codeine in the field. In the present work, potential modulation was combined with electrochemiluminescence (ECL) for sensitive determination of codeine. The potential modulated technique involved applying a signal to electrodes by superimposing an AC potential on the DC potential. When tris(2,2′-bipyridine) ruthenium(II) ([Ru(bpy) 3 ] 2 ) was used as an ECL emitter, ECL activity was confirmed for codeine. A detailed investigation of the electrochemical reaction mechanism suggested a characteristic ECL reaction mechanism involving electrochemical oxidation of the opioid framework. Besides the usual ECL reaction derived from the amine framework, selective detection of codeine was possible under the measurement conditions, with clear luminescence observed in an acidic solution. The sensitivity of codeine detection by potential modulated-ECL was one order of magnitude higher than that obtained with the conventional potential sweep method. The proposed method was applied to codeine determination in actual prescription medications and OTC drug samples. Codeine was selectively determined from other compounds in medications and showed good linearity with a low detection limit (150 ng mL 1 ).

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Section: Pm-ecl Behavior Of the [Ru(bpy) 3 ] 2+ /Codeine Systemmentioning

confidence: 99%

Development of a Potential-Modulated Electrochemiluminescence Measurement System for Selective and Sensitive Determination of the Controlled Drug Codeine

Takahashi,

Shimosaka,

Mori

et al. 2024

Chem. Pharm. Bull.

Self Cite

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“…In addition, electrochemical analytical methods are also considered to be sufficiently sensitive, precise, and accurate, which constantly brings them to the forefront in the field of doping control analysis [ 47 ]. According to the different identification methods used in the electrochemical detection process, the electrochemical detection modes of doping agents can roughly be divided into two categories: characteristic redox potential electrochemical sensors [ 48 , 49 ] and molecularly imprinted electrochemical sensors [ 46 , 50 ]. For example, Tarley’s group developed a reliable and selective voltammetric method to detect the designer drug, 1-(3-chlorophenyl) piperazine using a boron-doped diamond electrode.…”

Section: Drug Doping Detectionmentioning

confidence: 99%

A Review of Recent Progress in Drug Doping and Gene Doping Control Analysis

Yan

et al. 2023

Molecules

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The illicit utilization of performance-enhancing substances, commonly referred to as doping, not only infringes upon the principles of fair competition within athletic pursuits but also poses significant health hazards to athletes. Doping control analysis has emerged as a conventional approach to ensuring equity and integrity in sports. Over the past few decades, extensive advancements have been made in doping control analysis methods, catering to the escalating need for qualitative and quantitative analysis of numerous banned substances exhibiting diverse chemical and biological characteristics. Progress in science, technology, and instrumentation has facilitated the proliferation of varied techniques for detecting doping. In this comprehensive review, we present a succinct overview of recent research developments within the last ten years pertaining to these doping detection methodologies. We undertake a comparative analysis, evaluating the merits and limitations of each technique, and offer insights into the prospective future advancements in doping detection methods. It is noteworthy that the continual design and synthesis of novel synthetic doping agents have compelled researchers to constantly refine and innovate doping detection methods in order to address the ever-expanding range of covertly employed doping agents. Overall, we remain in a passive position for doping detection and are always on the road to doping control.

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Interpol Review of Drug Analysis 2019-2022

Love

Jones

2023

Forensic Science International: Synergy

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Sensitive screening of methamphetamine stimulant using potential-modulated electrochemiluminescence

Cited by 7 publications

References 29 publications

Development of a Potential-Modulated Electrochemiluminescence Measurement System for Selective and Sensitive Determination of the Controlled Drug Codeine

Development of a Potential-Modulated Electrochemiluminescence Measurement System for Selective and Sensitive Determination of the Controlled Drug Codeine

A Review of Recent Progress in Drug Doping and Gene Doping Control Analysis

Interpol Review of Drug Analysis 2019-2022

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