Sensitive spectrofluorimetric and mass spectroscopic methods for the determination of nucleic acid damage induced by photosensitized anti-inflammatory drugs: Comparative study

El-Yazbi, Amira F.; Guirguis, Karin M.; Belal, Tarek S.; Bedair, Mona M.

doi:10.1016/j.jpba.2020.113326

Cited by 21 publications

(9 citation statements)

References 21 publications

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“…DNA damage is a trigger for apoptosis and can be induced by many factors, including ultraviolet/ionizing radiation [ 34 , 35 ], endogenous metabolites [ 36 ], environmental and dietary carcinogens [ 37 ], some anti-inflammatory drugs [ 38 ], and genotoxic anticancer therapeutics [ 39 ]. DNA damage may be classified into many categories, consisting of DNA strand breaks, abnormal DNA cross-linking, point mutations, and gene mutations.…”

Section: Resultsmentioning

confidence: 99%

Mechanism-Based Sonodynamic–Chemo Combinations against Triple-Negative Breast Cancer

Feng

Chen

Yang

et al. 2022

IJMS

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Due to its noninvasive nature, site-confined irradiation, and high tissue penetrating capabilities, ultrasound (US)-driven sonodynamic treatment (SDT) has been proven to have broad application possibilities in neoplastic and non-neoplastic diseases. However, the inefficient buildup of sonosensitizers in the tumor site remarkably impairs SDT efficiency. The present work proposes a deep-penetrating sonochemistry nanoplatform (Pp18-lipos@SRA737&DOX, PSDL) comprising Pp18 liposomes (Pp18-lipos, Plipo), SRA737 (a CHK1 inhibitor), and doxorubicin (DOX) for the controlled formation of reactive oxygen species (ROS) and release of DOX and SRA737 upon US activation, therefore increasing chemotherapeutic effectiveness and boosting SDT efficacy. Therein, the antitumor activities of DOX have been attributed to its intercalation into the nucleus DNA and induction of cell apoptosis. CHK1 evolved to respond to DNA damage and repair the damage via cell cycle progression. SRA737 is a potent and orally bioavailable clinical drug candidate for inhibiting CHK1, demonstrating adjuvant anticancer effect in vitro and in vivo. It was interesting to find that SRA737 carried into Plipo@DOX could significantly alleviate G2/M cell cycle arrest and aggravate DNA double-strand injuries, resulting in significant cell death. The developed US-switchable nanosystem provides a promising strategy for augmenting sono-chemotherapy against breast cancer controllably and precisely.

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Section: Resultsmentioning

confidence: 99%

Mechanism-Based Sonodynamic–Chemo Combinations against Triple-Negative Breast Cancer

Feng

Chen

Yang

et al. 2022

IJMS

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“…In a study of five anti-inflammatory medications, incubation of piroxicam under UVA induced the formation of damaged single-stranded DNA [ 77 ]. On the other hand, piroxicam prevents tumor invasion by inhibiting angiogenesis, immunosuppression, growth factor recruitment and production of carcinogenic mediators [ 78 , 79 ].…”

Section: Resultsmentioning

confidence: 99%

Photosensitizing Medications and Skin Cancer: A Comprehensive Review

George

Baranwal

Kang

et al. 2021

Cancers

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(1) The incidence of skin cancer is increasing in the United States (US) despite scientific advances in our understanding of skin cancer risk factors and treatments. In vitro and in vivo studies have provided evidence that suggests that certain photosensitizing medications (PSMs) increase skin cancer risk. This review summarizes current epidemiological evidence on the association between common PSMs and skin cancer. (2) A comprehensive literature search was conducted to identify meta-analyses, observational studies and clinical trials that report on skin cancer events in PSM users. The associated risks of keratinocyte carcinoma (squamous cell carcinoma and basal cell carcinoma) and melanoma are summarized, for each PSM. (3) There are extensive reports on antihypertensives and statins relative to other PSMs, with positive and null findings, respectively. Fewer studies have explored amiodarone, metformin, antimicrobials and vemurafenib. No studies report on the individual skin cancer risks in glyburide, naproxen, piroxicam, chlorpromazine, thioridazine and nalidixic acid users. (4) The research gaps in understanding the relationship between PSMs and skin cancer outlined in this review should be prioritized because the US population is aging. Thus the number of patients prescribed PSMs is likely to continue to rise.

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“…Fluorescent biosensors are widely used as sensitive and selective tools for studying DNA interaction with small molecules and detection of any induced DNA damage that may have occurred. ,− In this study, the EvaGreen (EG) fluorescent biosensor was selected for studying the possible DNA interaction with compound 1 , as a series representative. EG is formed from two fluorescent monomers connected to each other with a flexible linker.…”

Section: Methodsmentioning

confidence: 99%

Inclusion of Nitrofurantoin into the Realm of Cancer Chemotherapy via Biology-Oriented Synthesis and Drug Repurposing

et al. 2023

Self Cite

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Structural modifications of the antibacterial drug nitrofurantoin were envisioned, employing drug repurposing and biology-oriented drug synthesis, to serve as possible anticancer agents. Eleven compounds showed superior safety in non-cancerous human cells. Their antitumor efficacy was assessed on colorectal, breast, cervical, and liver cancer cells. Three compounds induced oxidative DNA damage in cancer cells with subsequent cellular apoptosis. They also upregulated the expression of Bax while downregulated that of Bcl-2 along with activating caspase 3/7. The DNA damage induced by these compounds, demonstrated by pATM nuclear shuttling, was comparable in both MCF7 and MDA-MB-231 (p53 mutant) cell lines. Mechanistic studies confirmed the dependence of these compounds on p53-mediated pathways as they suppressed the p53–MDM2 interaction. Indeed, exposure of radiosensitive prostatic cancer cells to low non-cytotoxic concentrations of compound 1 enhanced the cytotoxic response to radiation indicating a possible synergistic effect. In vivo antitumor activity was verified in an MCF7-xenograft animal model.

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Sensitive spectrofluorimetric and mass spectroscopic methods for the determination of nucleic acid damage induced by photosensitized anti-inflammatory drugs: Comparative study

Cited by 21 publications

References 21 publications

Mechanism-Based Sonodynamic–Chemo Combinations against Triple-Negative Breast Cancer

Mechanism-Based Sonodynamic–Chemo Combinations against Triple-Negative Breast Cancer

Photosensitizing Medications and Skin Cancer: A Comprehensive Review

Inclusion of Nitrofurantoin into the Realm of Cancer Chemotherapy via Biology-Oriented Synthesis and Drug Repurposing

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