Sensitive Spectrophotometric Method for Determination of Chloramphenicol in Pharmaceutical Preparations Using 7,7',8,8'-tetracyanoquinodimethane reagent

Chemistry, Hayfa M. Al-Hammoshi Department of; Al-Sabha, Theia'a N.

doi:10.33899/edusj.2013.89817

J.Edu.Sci.

2013

DOI: 10.33899/edusj.2013.89817

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Sensitive Spectrophotometric Method for Determination of Chloramphenicol in Pharmaceutical Preparations Using 7,7',8,8'-tetracyanoquinodimethane reagent

Hayfa M. Al-Hammoshi Department of Chemistry¹,

Theia'a N. Al-Sabha²

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2019

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Using of 2,7-Dihydroxynaphthalene as a Novel Reagent in Spectrophotometric Assay of Chloramphenicol

Othman¹,

Jamal²

2019

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An indirect spectrophotometric method for the determination of chloramphenicol (CAP) has been suggested. The method is based on the oxidative coupling reaction of reduced chloramphenicol (R-CAP) with 2,7-dihydroxynaphthalene (2,7-DHN) reagent in the presence of potassium dichromate as oxidizing agent to produce brown colored, stable and soluble product. This product showed maximum absorption at 544 nm. Beer's law is obeyed over the range 0.5-7.5.µg.ml-1 of R-CAP and molar absorptivity of 1.069×10 5 l.mol-1 .cm-1 and Sandell's sensitivity index of 0.0030 µg.cm-2 , limit of detection (LOD), limit of quantitation (LOQ), relative error (RE%) and relative standard deviation (RSD%) have been estimated. The method has been successfully applied to the determination of CAP in drug formulations.

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Using of 2,7-Dihydroxynaphthalene as a Novel Reagent in Spectrophotometric Assay of Chloramphenicol

Othman¹,

Jamal²

2019

RJS

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Sensitive Spectrophotometric Method for Determination of Chloramphenicol in Pharmaceutical Preparations Using 7,7',8,8'-tetracyanoquinodimethane reagent

Cited by 1 publication

References 24 publications

Using of 2,7-Dihydroxynaphthalene as a Novel Reagent in Spectrophotometric Assay of Chloramphenicol

Using of 2,7-Dihydroxynaphthalene as a Novel Reagent in Spectrophotometric Assay of Chloramphenicol

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