Sensitive Zika biomarker detection assisted by quantum dot-modified electrochemical immunosensing platform

Ribeiro, Jéssika F.F.; Melo, José R.S.; Santos, Caroline de L.; Chaves, Claudilene R.; Filho, Paulo E. Cabral; Pereira, Goreti; Santos, Beate S.; Pereira, Giovannia A. L.; Rosa, Daniela Santoro; Ribeiro, Rogério; Fontes, Adriana

doi:10.1016/j.colsurfb.2022.112984

Cited by 10 publications

(5 citation statements)

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“…This section describes nanomaterials that are somewhat less common but are also successfully used to create impedimetric biosensors. Such materials include colloidal quantum dots [152,153], which during the synthesis process are formed with a shell of ligand molecules, two-dimensional nanomaterials from other semiconductor compounds [154][155][156], and, finally, magnetic nanoparticles [157,158].…”

Section: Other Nanomaterialsmentioning

confidence: 99%

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Hybrid Impedimetric Biosensors for Express Protein Markers Detection

Sitkov,

Ryabko,

Moshnikov

et al. 2024

Micromachines

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Impedimetric biosensors represent a powerful and promising tool for studying and monitoring biological processes associated with proteins and can contribute to the development of new approaches in the diagnosis and treatment of diseases. The basic principles, analytical methods, and applications of hybrid impedimetric biosensors for express protein detection in biological fluids are described. The advantages of this type of biosensors, such as simplicity and speed of operation, sensitivity and selectivity of analysis, cost-effectiveness, and an ability to be integrated into hybrid microfluidic systems, are demonstrated. Current challenges and development prospects in this area are analyzed. They include (a) the selection of materials for electrodes and formation of nanostructures on their surface; (b) the development of efficient methods for biorecognition elements’ deposition on the electrodes’ surface, providing the specificity and sensitivity of biosensing; (c) the reducing of nonspecific binding and interference, which could affect specificity; (d) adapting biosensors to real samples and conditions of operation; (e) expanding the range of detected proteins; and, finally, (f) the development of biosensor integration into large microanalytical system technologies. This review could be useful for researchers working in the field of impedimetric biosensors for protein detection, as well as for those interested in the application of this type of biosensor in biomedical diagnostics.

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Section: Other Nanomaterialsmentioning

confidence: 99%

“…In [153], a biosensor for detecting Zika virus envelope protein (EP-ZIKV) was developed based on an electrode with carboxylated CdTe QDs. Quantum dots were obtained in the form of an aqueous colloidal dispersion using mercaptosuccinic acid as a stabilizing agent (ligand molecules).…”

Section: Other Nanomaterialsmentioning

confidence: 99%

Hybrid Impedimetric Biosensors for Express Protein Markers Detection

Sitkov,

Ryabko,

Moshnikov

et al. 2024

Micromachines

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“…Notably, QDs possess a chemically active surface, facilitating their functionalization and enhancing their affinity with the analyte [ 6 ]. QDs have emerged as luminescent probes in analytical chemistry to develop various sensor types, including optical, electrochemical, and colorimetric [ 2 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Development of Fluorescent Sensors for Biorelevant Anions in Aqueous Media Using Positively Charged Quantum Dots

Silva,

Pereira,

Pereira

et al. 2024

Micromachines

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Quantum dots (QDs) have captured the attention of the scientific community due to their unique optical and electronic properties, leading to extensive research for different applications. They have also been employed as sensors for ionic species owing to their sensing properties. Detecting anionic species in an aqueous medium is a challenge because the polar nature of water weakens the interactions between sensors and ions. The anions bicarbonate (HCO3−), carbonate (CO32−), sulfate (SO42−), and bisulfate (HSO4−) play a crucial role in various physiological, environmental, and industrial processes, influencing the regulation of biological fluids, ocean acidification, and corrosion processes. Therefore, it is necessary to develop approaches capable of detecting these anions with high sensitivity. This study utilized CdTe QDs stabilized with cysteamine (CdTe-CYA) as a fluorescent sensor for these anions. The QDs exhibited favorable optical properties and high photostability. The results revealed a gradual increase in the QDs’ emission intensity with successive anion additions, indicating the sensitivity of CdTe-CYA to the anions. The sensor also exhibited selectivity toward the target ions, with good limits of detection (LODs) and quantification (LOQs). Thus, CdTe-CYA QDs show potential as fluorescent sensors for monitoring the target anions in water sources.

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“…9 Additionally, CdTe quantum dots exhibit a high surface-to-volume ratio, providing an extensive interface area for biomolecular interactions, making them promising for the development of highly sensitive biosensors. 10,11 The current study outlines the assembly and application of an optical and electrochemical immunosensor utilizing the Cys-CdTe-Antibody DENV sensing platform (Fig. 1) as a promising alternative for identifying DENV-1 and DENV-2.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%