Sensitivity and Specificity of Diffusion-Weighted Magnetic Resonance Imaging in Diagnosis of Bladder Cancers

Zhai, Ning; Wang, Yanhui; Zhu, Lai-Ming; Wang, Jiehuan; Sun, Xun; Xibin, HU; Li, Xian; Yu, Tao; Wang, Xinling; Meng, Nan; Yan, Qichang; Li, Xuejiao; Luo, Yahong

doi:10.25011/cim.v38i4.24262

Cited by 18 publications

(4 citation statements)

References 32 publications

(38 reference statements)

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“…Several studies (6,10,11,(17)(18)(19)21) have had a wide range of partially conflicting results for DWI MR imaging in differentiating T1 or lower tumors from T2 or higher tumors. This motivated researchers to perform a recently published meta-analysis (33), which included eight studies published before September 2014 in English or Chinese. It involved 259 T2 or higher lesions and 515 T1 or lower lesions.…”

Section: Evidence-based Practice: Diagnostic Value Of Mr Imaging In Dmentioning

confidence: 99%

The Diagnostic Value of MR Imaging in Differentiating T Staging of Bladder Cancer: A Meta-Analysis

et al. 2018

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Purpose To assess the diagnostic accuracy of magnetic resonance (MR) imaging for differentiating stage T1 or lower tumors from stage T2 or higher tumors and to analyze the influence of different imaging protocols in patients with bladder cancer. Materials and Methods A systematic literature search for original diagnostic studies was performed in PubMed, Medline, the Cochrane Library, and Web of Science. The methodologic quality of each study was evaluated by two independent reviewers who used the Quality Assessment of Diagnostic Accuracy Studies 2 tool. Data necessary to complete 2 × 2 tables were obtained, and patient, study, and imaging characteristics were extracted. Statistical analysis included data pooling, heterogeneity testing, sensitivity analyses, and forest plot construction. Results Seventeen studies (1449 patients with bladder cancer) could be analyzed. The pooled sensitivity and specificity of MR imaging were 0.90 (95% confidence interval [CI]: 0.83, 0.94) and 0.88 (95% CI: 0.77, 0.94), respectively, for differentiating tumors staged T1 or lower from those staged T2 or higher. Diffusion-weighted imaging and use of higher field strengths (3 T) improved sensitivity (0.92; 95% CI: 0.86, 0.96) and specificity (0.96; 95% CI: 0.93, 0.98). Conclusion This meta-analysis demonstrated high diagnostic performance of MR imaging for differentiating T1 or lower tumors from T2 or higher tumors in patients with bladder cancer. Higher field strength (3 T) and the use of diffusion-weighted imaging can slightly help improve sensitivity and specificity. RSNA, 2017.

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Section: Evidence-based Practice: Diagnostic Value Of Mr Imaging In Dmentioning

confidence: 99%

The Diagnostic Value of MR Imaging in Differentiating T Staging of Bladder Cancer: A Meta-Analysis

et al. 2018

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“…These evaluations of MRI are limited by small sample sizes and variable techniques. Previous meta‐analyses on MRI for staging of bladder cancer are limited by restricted focus on the index test (e.g., DWI only ) or focus on only one threshold of disease (e.g., ≤T1 vs ≥T2 ).…”

Section: Introductionmentioning

confidence: 99%

Diagnostic accuracy of magnetic resonance imaging for tumour staging of bladder cancer: systematic review and meta‐analysis

et al. 2018

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The purpose of this study is to evaluate accuracy of magnetic resonance imaging (MRI) for local staging of bladder cancer for four clinical scenarios (T-stage thresholds) considered against current standards for clinical staging and secondarily to identify sources for variability in accuracy. Systematic review of patients with bladder cancer undergoing T-staging MRI to evaluate the diagnostic accuracy using bivariate random-effects meta-analysis. Sub-group analysis was done to explore variability; risk of bias was assessed using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS)-2 tool. The search identified 30 studies (5156 patients). Pooled accuracy at multiple T-stage thresholds: ≤T1 vs ≥T2 = sensitivity 87% (95% confidence interval [CI] 82-91), specificity 79% (95% CI 72-85); T-any vs T0 = sensitivity 65% (95% CI 23-92), specificity 90% (95% CI 83-94); ≤T2 vs ≥T3 = sensitivity 83% (95% CI 75-88), specificity 87% (95% CI 78-93); and

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“…Zhang et al[54] meta-analysis reported the differences in ADC values between benign renal lesions (2.47 ± 0.81 × 10 -3 mm 2 /s) and malignant renal lesions (1.81 ± 0.41 × 10 -3 mm 2 /s) with a P value < 0.001. DWI is also studied in bladder malignancies, especially to evaluate the depth of invasion, deciding the T stage of bladder cancer which decides the management protocol[57,58]. Management of urinary bladder cancer is primarily determined on distinguishing superficial tumors (stage T1 or lower) from invasive ones (stage T2 or higher).…”

Section: Applications Of Dwi In Oncologymentioning

confidence: 99%

Diffusion magnetic resonance imaging: A molecular imaging tool caught between hope, hype and the real world of “personalized oncology”

Mahajan

Deshpande

Thakur

2017

WJR

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“Personalized oncology” is a multi-disciplinary science, which requires inputs from various streams for optimal patient management. Humongous progress in the treatment modalities available and the increasing need to provide functional information in addition to the morphological data; has led to leaping progress in the field of imaging. Magnetic resonance imaging has undergone tremendous progress with various newer MR techniques providing vital functional information and is becoming the cornerstone of “radiomics/radiogenomics”. Diffusion-weighted imaging is one such technique which capitalizes on the tendency of water protons to diffuse randomly in a given system. This technique has revolutionized oncological imaging, by giving vital qualitative and quantitative information regarding tumor biology which helps in detection, characterization and post treatment surveillance of the lesions and challenging the notion that “one size fits all”. It has been applied at various sites with different clinical experience. We hereby present a brief review of this novel functional imaging tool, with its application in “personalized oncology”.

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Sensitivity and Specificity of Diffusion-Weighted Magnetic Resonance Imaging in Diagnosis of Bladder Cancers

Cited by 18 publications

References 32 publications

The Diagnostic Value of MR Imaging in Differentiating T Staging of Bladder Cancer: A Meta-Analysis

The Diagnostic Value of MR Imaging in Differentiating T Staging of Bladder Cancer: A Meta-Analysis

Diagnostic accuracy of magnetic resonance imaging for tumour staging of bladder cancer: systematic review and meta‐analysis

Diffusion magnetic resonance imaging: A molecular imaging tool caught between hope, hype and the real world of “personalized oncology”

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