Sensitivity and Specificity of Multispectral Imaging for Polypoidal Choroidal Vasculopathy

Abstract

Purpose: To evaluate the sensitivity and specificity of multispectral imaging (MSI), a noninvasive imaging technique composed of a series of monochromatic scanning light, for polypoidal choroidal vasculopathy (PCV).Methods: This was a prospective observational study. Polypoidal lesions on MSI are defined by oval or lobular hyperreflective oval lesion with dark hyporeflective center. Branching vascular networks on MSI is featured by hyperreflective interlacing signal. Detection sensitivity and specificity of polypoidal lesions was compared with indocyanine green angiography, whereas sensitivity and specificity of branching vascular networks, subretinal fluid, and pigment epithelium detachment were compared with optical coherence tomography.Results: Among 67 eyes, 38 eyes (56.7%) were diagnosed with PCV, 7 eyes (10.4%) with neovascular age-related macular degeneration, 13 eyes (19.4%) with central serous chorioretinopathy, 6 eyes (9.0%) with pathological myopia, and 3 eyes (4.5%) with idiopathic choroidal neovascularization. Compared with indocyanine green angiography, the sensitivity and specificity for diagnosing PCV by MSI alone was 84.21% and 93.10%, respectively, and the positive predictive value and the negative predictive value for PCV by MSI was 94.12% and 81.82%, respectively. The sensitivity and specificity for detecting polypoidal lesions were 84.21% and 93.10% compared with indocyanine green angiography. Compared with optical coherence tomography, the sensitivity and specificity for detecting branching vascular networks were 95.83% and 88.37%, for the subretinal fluid were 76.92% and 86.67%, and for the pigment epithelium detachment were 91.11% and 90.91%, respectively.Conclusion: Multispectral imaging allowed noninvasive visualization of polypoidal lesions and branching vascular networks and may serve as a new diagnostic option for PCV.

Multimodal Fundus Imaging for Central Serous Chorioretinopathy

“…Multispectral fundus imaging utilizes an array of monochromatic light-emitting diode light sources to project onto different depths, including the RPE layer and choroid, of the retinal tissue. 54 The different tissues absorb varying spectrums of light. Monochromatic light reflection images from different depths of the retina are collected to form monochromatic spectral images, presented in an en face format.…”

Advances in multi-modal non-invasive imaging techniques in the diagnosis and treatment of polypoidal choroidal vasculopathy

“…Multi-spectrum imaging (MSI) is an imaging method that records images in spectral form and has been attempted for the diagnosis of PCV. Ma et al (29) found that PLs can be observed at wavelengths of 680 nm and above as lobes of "hyperborder, hypocenter" pattern lesions, and BNN can be vaguely observed as an area of interlacing hyper-reflectance with linear or dot of signals. Subretinal fluid appears as local blurred hyperreflective areas under short wavelengths, and PED can appear as a slightly high-reflective border.…”

Light color efficiency-balanced trans-palpebral illumination for widefield fundus photography of the retina and choroid

“…Multispectral imaging (MSI) technology, which employs multiple wavelengths from visible to near infrared, has been reported to visualize choroidal fundus. However, currently available MSI systems have limited FOV, typically 45° visual-angle (68° eye-angle) 10 – 12 .…”