Sensitivity and Validity of Psychometric Tests for Assessing Driving Impairment: Effects of Sleep Deprivation

Jongen, Stefan; Perrier, Joy; Vuurman, E.F.P.M.; Ramaekers, Johannes G.; Vermeeren, Annemiek

doi:10.1371/journal.pone.0117045

Cited by 52 publications

(42 citation statements)

References 70 publications

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“…Foot position is standardized between trials by markings on the platform. Recent studies have shown that postural balance as measured with this test is sensitive to low and moderate doses of alcohol, sleep deprivation, and residual effects of hypnotics (Vermeeren et al 2015 ; Jongen et al 2014 , 2015 ).…”

Section: Methodsmentioning

confidence: 99%

On-the-road driving performance the morning after bedtime use of suvorexant 15 and 30 mg in healthy elderly

Vermeeren

Vets²,

Vuurman

et al. 2016

Psychopharmacology

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RationaleSuvorexant is a first-in-class orexin receptor antagonist for treating insomnia. There is a general concern that hypnotics may impair next-morning driving ability.ObjectiveThe objective of this study was to evaluate next-morning driving performance in older adults after single and repeated doses of suvorexant.MethodsDouble-blind, randomized, placebo-controlled, 4-period crossover study in 24 healthy volunteers (10 females), aged 65–80 years. Subjects were treated with suvorexant (15 and 30 mg) for eight consecutive nights, zopiclone 7.5 mg nightly on days 1 and 8, and placebo. Driving performance was assessed on days 2 and 9 (9 h after dosing) using a 1-h standardized highway driving test in normal traffic, measuring standard deviation of lateral position (SDLP). Drug-placebo differences in SDLP >2.4 cm were considered to reflect clinically meaningful driving impairment.ResultsDriving performance as measured by SDLP was not impaired following suvorexant. Mean drug–placebo differences in SDLP following suvorexant 15 and 30 mg on day 2 and 9 were 0.6 cm or less. Their 90 % CIs were all below the threshold of 2.4 cm for clinical relevance and included zero, indicating effects were not clinically meaningful or statistically significant. Symmetry analysis showed no significant differences between the number of participants who had SDLP differences >2.4 cm and those who had SDLP differences <−2.4 cm following suvorexant.ConclusionsThere was no clinically meaningful residual effect of suvorexant 15 and 30 mg on next-morning driving (9 h after bedtime dosing) in healthy older adults, as assessed by mean changes in SDLP and by the number of participants on drug versus placebo that exceeded a predetermined threshold for clinically meaningful impairment.Electronic supplementary materialThe online version of this article (doi:10.1007/s00213-016-4375-x) contains supplementary material, which is available to authorized users.

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Section: Methodsmentioning

confidence: 99%

On-the-road driving performance the morning after bedtime use of suvorexant 15 and 30 mg in healthy elderly

Vermeeren

Vets²,

Vuurman

et al. 2016

Psychopharmacology

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“…smoking impairs psychomotor ability, divided attention, and motor impulsivity in NRU, while impairing only motor impulsivity in RU at high ∆9-THC concentrations (Ramaekers et al, 2009), suggesting that RU develop tolerance also to the effect of ∆9-THC on psychomotor ability (Ramaekers et al, 2009). It is worth mentioning that this study used a different task, the Critical Tracking Test (CTT), which specifically assesses psychomotor coordination rather than a wider range of psychomotor functions at the same time as for the DSST (Jongen et al, 2015). Similar findings were reported in 2015 by Desrosiers et al who showed that the ∆9-THC marijuana impairs CTT psychomotor ability and divided attention more prominently in NRU than RU, also increasing the number of tracking errors and false alarms as well as prolonging reaction times during divided attention only in NRU (Desrosiers et al, 2015).…”

Section: Cognitive Functionmentioning

confidence: 99%

Cannabis use and the development of tolerance: a systematic review of human evidence

Colizzi

Bhattacharyya

2018

Neuroscience & Biobehavioral Reviews

119

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Previous studies have reported conflicting results in terms of acute effects of cannabis in man. Independently of other factors, such discrepancy may be attributable to the different cannabis use history of study volunteers. It is thought that regular cannabis users may develop tolerance to the effects of acute cannabis administration. Here we systematically review all studies examining the effects of single or repeated cannabinoid administration in man as a function of previous cannabis exposure. Research evidence tends to suggest that the acute effects of single cannabinoid administration are less prominent in regular cannabis users compared to non-regular users. Studies of repeated cannabinoid administration more consistently suggest less prominent effects upon repeated exposure. Cognitive function is the domain showing the highest degree of tolerance, with some evidence of complete absence of acute effect (full tolerance). The acute intoxicating, psychotomimetic, and cardiac effects are also blunted upon regular exposure, but to a lesser extent (partial tolerance). Limited research also suggests development of tolerance to other behavioral, physiological, and neural effects of cannabis.

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“…The described method of assessing fitness-to-drive using a driving simulator is more predictive for the driving competence in real traffic compared to traditional psychometric testing (e.g. Jongen et al 2015). Regarding the minimum requirements on simulator configuration, a quite cost-efficient compact simulator is sufficient.…”

Section: Discussionmentioning

confidence: 99%

Are Driving Simulators Suitable to Measure the Driving Competence of Elderly Drivers?

Kenntner-Mabiala

Maag

Kaussner

et al. 2019

Proceedings of the 10th International Driving Symposium on Human Factors in Driver Assessment, Training and Vehicle Design: Dri

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The present project aimed to develop and validate a methodology for driving simulators to assess and diagnose driving ability of elderly drivers. A driving simulation course has been developed which covered a representative selection of driving tasks of moderate difficulty as well as scenarios which are particularly difficult for elderly drivers. Driving errors were semi-automatically registered and classified by a tablet PC application. Based on the registered driving errors, the driving competence of each driver was rated on an 11-point fitness-to-drive (FtD) rating scale by specifically trained raters. The driving course was validated on the basis of a 60-minute standardized driving test in real traffic. By including similar driving tasks, it was ensured that it was structurally comparable to the simulated course. 30 elderly drivers (> 70 years) and 30 control drivers (25-50 years) were assessed in the simulation and in real traffic. During the driving tests, more driving errors were registered for the elderly drivers than for the controls both in the simulator and in real traffic. FtD-ratings and total number of driving errors during the driving tests in the simulation correlated up to r = .80 with the FtD-ratings of the driving tests in real traffic. ROC-Analyses revealed at Sensitivity-Specificity Ratio of 85.71 : 82.61 at best. Overall, driving simulation was well accepted by the subjects. The findings of the study confirm the validity of driving simulation as a tool to diagnose driving ability and argue for its introduction as a diagnostic tool.

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Sensitivity and Validity of Psychometric Tests for Assessing Driving Impairment: Effects of Sleep Deprivation

Cited by 52 publications

References 70 publications

On-the-road driving performance the morning after bedtime use of suvorexant 15 and 30 mg in healthy elderly

On-the-road driving performance the morning after bedtime use of suvorexant 15 and 30 mg in healthy elderly

Cannabis use and the development of tolerance: a systematic review of human evidence

Are Driving Simulators Suitable to Measure the Driving Competence of Elderly Drivers?

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