Sensitivity of MRI parameters within intervertebral discs to the severity of adolescent idiopathic scoliosis

Huber, Maxime; Gilbert, Guillaume; Roy, Julien Le; Parent, Stefan; Périé, Delphine

doi:10.1002/jmri.25260

Cited by 11 publications

(8 citation statements)

References 30 publications

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“…It was also hypothesized that SWS should increase with deformation severity, but no correlation was observed between SWS and Cobb angle. Huber et al [31] reported that degeneration of IVD is greater within the curvature than in healthy areas, so it is possible that this lack of correlation, in our study, is due to the pooling of different spinal topologies.…”

Section: Discussionmentioning

confidence: 59%

“…Kobielarz et al [35] confirmed this alteration and reported that the number of elastin fiber and collagen I were reduced in AF. In vivo, Huber et al [31] showed by MRI that IVD were more degenerated in scoliosis than healthy IVD whereas Schlösser et al found by CT scan analysis that deformation in 3-D was greater in the IVD than in the vertebral bodies [15].…”

Section: Discussionmentioning

confidence: 99%

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Shear-wave elastography can evaluate annulus fibrosus alteration in adolescent scoliosis

et al. 2018

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Shear-wave elastography can evaluate annulus fibrosus alteration in adolescent scoliosis

et al. 2018

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“…Scoliosis was more severe in untreated children than in MCGR-treated children. Scoliosis itself was proven as a risk factor of IDD [ 27 , 28 , 29 ]. However, in this population, prior MCGR therapy had a more severe effect on disc health than the actual degree of scoliosis.…”

Section: Discussionmentioning

confidence: 99%

Smaller Intervertebral Disc Volume and More Disc Degeneration after Spinal Distraction in Scoliotic Children

Lippross¹,

Girmond²,

Lüders³

et al. 2021

JCM

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In recent decades, magnetically controlled growing rods (MCGR) were established to treat progressive early-onset scoliosis. The aim of this investigation was to assess the effect of long-term MCGR with continuous distraction on intervertebral discs in scoliotic children. Magnetic resonance imaging (MRI) of 33 children with spinal muscular atrophy was analyzed by grading intervertebral disc degeneration (IDD) and measuring intervertebral disc volume. Cohort I (n = 17) were children who had continuous spinal distraction with MCGRs for 5.1 years and MRI before (av. age 8.1) and after (av. age 13.4) MCGR treatment. Cohort II (n = 16, av. age 13.7) were patients without prior surgical treatment. Lumbar intervertebral disc volume of cohort I did not change during 5.1 years of MCGR treatment, whereas disc volumes were significantly larger in age- and disease-matched children without prior treatment (cohort II). Cohort I showed more IDD after MCGR treatment in comparison to early MRI studies of the same patients and children without surgical treatment. MRI data showed a volume reduction and disc degeneration of lower thoracic and lumbar intervertebral discs in scoliotic children after continuous spinal distraction with MCGRs. These effects were confirmed in the same subjects before and after treatment as well as in surgically untreated controls.

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“…Multiparametric magnetic resonance imaging (MRI) has been used to investigate alterations in mechanical properties in the intervertebral disc using linear regressions to relaxation times T 1 , T 2 and T 1rho , magnetization transfer ratios, apparent diffusion coefficients and fractions of anisotropy . Multiparametric MRI, associated with principal component analysis and agglomerative hierarchical clustering, is a promising tool for the classification of degenerated intervertebral discs and for the further identification of biomarkers of the evolution of spine pathologies . However, MRI parameters, including the relaxation time constants T 1 and T 2 , are magnetic field strength dependent.…”

Section: Introductionmentioning

confidence: 99%

“…[26][27][28][29][30][31] Multiparametric MRI, associated with principal component analysis and agglomerative hierarchical clustering, is a promising tool for the classification of degenerated intervertebral discs and for the further identification of biomarkers of the evolution of spine pathologies. 32 However, MRI parameters, including the relaxation time constants T 1 and T 2 , are magnetic field strength dependent. In addition, regressions between mechanical properties and MRI parameters are dependent on the tissue degradation state, making in vivo application difficult.…”

mentioning

confidence: 99%

Frequency‐dependent shear properties of annulus fibrosus and nucleus pulposus by magnetic resonance elastography

et al. 2018

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Aging and degeneration are associated with changes in mechanical properties in the intervertebral disc, generating interest in the establishment of mechanical properties as early biomarkers for the degenerative cascade. Magnetic resonance elastography (MRE) of the intervertebral disc is usually limited to the nucleus pulposus, as the annulus fibrosus is stiffer and less hydrated. The objective of this work was to adapt high-frequency needle MRE to the characterization of the shear modulus of both the nucleus pulposus and annulus fibrosus. Bovine intervertebral discs were removed from fresh oxtails and characterized by needle MRE. The needle was inserted in the center of the disc and vibrations were generated by an amplified piezoelectric actuator. MRE acquisitions were performed on a 4.7-T small-animal MR scanner using a spin echo sequence with sinusoidal motion encoding gradients. Acquisitions were repeated over a frequency range of 1000-1800 Hz. The local frequency estimation inversion algorithm was used to compute the shear modulus. Stiffness maps allowed the visualization of the soft nucleus pulposus surrounded by the stiffer annulus fibrosus surrounded by the homogeneous gel. A significant difference in shear modulus between the nucleus pulposus and annulus fibrosus, and an increase in the shear modulus with excitation frequency, were observed, in agreement with the literature. This study demonstrates that global characterization of both the nucleus pulposus and annulus fibrosus of the intervertebral disc is possible with needle MRE using a preclinical magnetic resonance imaging (MRI) scanner. MRE can be a powerful method for the mapping of the complex properties of the intervertebral disc. The developed method could be adapted for in situ use by preserving adjacent vertebrae and puncturing the side of the intervertebral disc, thereby allowing an assessment of the contribution of osmotic pressure to the mechanical behavior of the intervertebral disc.

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Sensitivity of MRI parameters within intervertebral discs to the severity of adolescent idiopathic scoliosis

Cited by 11 publications

References 30 publications

Shear-wave elastography can evaluate annulus fibrosus alteration in adolescent scoliosis

Shear-wave elastography can evaluate annulus fibrosus alteration in adolescent scoliosis

Smaller Intervertebral Disc Volume and More Disc Degeneration after Spinal Distraction in Scoliotic Children

Frequency‐dependent shear properties of annulus fibrosus and nucleus pulposus by magnetic resonance elastography

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