Sensitivity pattern among bacterial isolates in neonatal septicaemia in port Harcourt

Abstract

BackgroundThe organisms responsible for neonatal sepsis vary across geographical boundaries and with the time of illness thus periodic bacteriologic surveillance is a neccessity. The present study was therefore carried out to determine the common bacterial pathogens in Port Harcourt and their sensitivity pattern.MethodsFour hundred and six neonates were prospectively screened for sepsis over a 6 month period. Sensitivity of the bacterial isolates to different antibiotics was determined using Kirby-Bauer diffusion method.ResultsGram negative organisms predominated (75.1%) with Klebsiella pneumonia (58.2%) being the commonest. The quinolones were the most sensitive antibiotics to the commonly isolated organisms.ConclusionKlebsiella pneumonia is the commonest organism responsible for neonatal sepsis in Port Harcourt. There is an overall decline in the antibiotic susceptibility to the commonly isolated bacterial pathogens.

Neonatal sepsis: epidemiology, clinical spectrum, recent antimicrobial agents and their antibiotic susceptibility pattern

“…Lancefield grouping is not done in our institution. Similar to our study Klebseilla is found most common organism in study done by Desai et al 9 (47.14%), Rathore et al 10 (55.14%), West Peterside et al 11 (58.2%). In study in third generation cephalosporins only one organism (Strept.…”

Neonatal septicaemia: prevalence and antimicrobial susceptibility patterns of common pathogens at Princess Marina Hospital, Botswana

“…16 Much higher rates of neonatal LCBI (33.1%) were reported from a Nigerian special care infant unit. 17 Many studies report on blood culture yield, rather than result of the predominance of late-onset neonatal sepsis. Most neonates were given empirical antibiotics at birth for prematurity, or had experienced an earlier episode of suspected sepsis.…”

“…Our study and others from Africa report a higher prevalence of late-onset neonatal sepsis. 12,17,23,24 This pattern represents horizontal infection transmission, i.e. hospitalacquired infections, which are largely preventable by good infection control practices.…”

Antibiotic resistance—the need for global solutions

“…Neonatal nurseries in some LMICs report meticillin resistance rates of 17-28% in S aureus isolates. 40,216,237 Similarly, Lubell and colleagues 238 recorded poor susceptibility to almost all commonly used antibiotics in pathogens such as S aureus and Klebsiella spp. Without rigorous evidence, most clinicians agree that 90% susceptibility or higher of potential pathogens to antibiotics in critical care settings like neonatal intensive care units, and 80% or higher in non-critical health-care settings, is acceptable.…”