Sensitivity, specificity, and diagnostic accuracy of three dermoscopic algorithmic methods in the diagnosis of doubtful melanocytic lesions

Annessi, Giorgio; Bono, R.; Sampogna, Francesca; Faraggiana, Tullio; Abeni, Damiano

doi:10.1016/j.jaad.2007.01.014

Cited by 116 publications

(75 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The accuracy we report with dermoscopy is however similar to recent research and metaanalysis reported to date. In a series of 198 melanocytic lesions, Annessi et al[ 24] report sensitivity, specificity and diagnostic accuracy of melanoma using the pattern analysis method of 85.4, 74.5 and 82.3%, respectively. In addition, a recent metaanalysis of 13 dermoscopic studies indicated similar results with a diagnostic accuracy of dermoscopy of 83.2% and a specificity of 85.8% [25].…”

Section: Discussionmentioning

confidence: 99%

“…Dermoscopy is a noninvasive technique which has currently received the widest clinical use, and there is evidence that it can improve the diagnostic accuracy in the assessment of benign and malignant melanocytic lesions [4,5,6,7,23,24,25]. CSLM is a promising noninvasive imaging technique which provides high-resolution, instantaneous, cellular-level detail of human skin in vivo.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Diagnostic Accuracy of in vivo Confocal Scanning Laser Microscopy Compared to Dermoscopy of Benign and Malignant Melanocytic Lesions: A Prospective Study

Langley

Walsh²,

Sutherland³

et al. 2007

Dermatology

112

View full text Add to dashboard Cite

Background: The diagnosis of melanoma at an early, curable stage is an important challenge for clinicians. Confocal scanning laser microscopy (CSLM) is a high-resolution, noninvasive technology that may facilitate improved diagnostic accuracy over clinical examination. The aim of this study was to evaluate the diagnostic accuracy of CSLM compared to dermoscopy in a prospective examination of benign and malignant melanocytic lesions. Methods: 125 patients with suspicious pigmented lesions were prospectively recruited to undergo a clinical, dermoscopic and CSLM examination. A diagnosis was made preoperatively with each technique, and the lesion was then excised and diagnosed using histopathology. Results: 125 patients with 125 lesions were studied comprising 88 melanocytic nevi and 37 melanomas. Dermoscopy had a sensitivity of 89.2%, a specificity of 84.1%, a positive predictive value of 70.2% and a negative predictive value of 94.9%. CSLM was found to have a sensitivity of 97.3%, a specificity of 83.0%, a positive predictive value of 70.6% and a negative predictive value of 98.6%. No melanomas were misidentified when both techniques were used together. Conclusions: CSLM had a relatively higher sensitivity than dermoscopy; however, the specificity was similar with CSLM and dermoscopy. These results suggest that dermoscopy and CSLM are complementary.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Diagnostic Accuracy of in vivo Confocal Scanning Laser Microscopy Compared to Dermoscopy of Benign and Malignant Melanocytic Lesions: A Prospective Study

Langley

Walsh²,

Sutherland³

et al. 2007

Dermatology

112

View full text Add to dashboard Cite

show abstract

“…In fact, dermoscopy is able to increase the diagnostic sensitivity of melanoma by 10 to 35% compared with clinical observation alone (18)(19)(20). Dermoscopic characterization of nodular melanoma is limited owing to the diagnostic difficulties posed by the morphologic features of the lesion and the dermal component of nodular malignant proliferation.…”

Section: Dermoscopic Featuresmentioning

confidence: 99%

Diagnostic spectrum of nodular melanoma

Stanganelli¹

2016

cderm

View full text Add to dashboard Cite

SummaryNodular melanoma represents 10 to 30% of all melanomas and circa 50% of those with a Breslow thickness greater than 2 mm. The main cause of death among malignant cutaneous tumors, it presents a high metastatic potential even in the early growth stages, making an early diagnosis fundamental. It is more common in men than in women, its onset is in later age, in any part of the body, more often on the neck and head. Due to its clinical characteristics (symmetrical, nodular, amelanotic/hypomelanotic or highly pigmented lesion) nodular melanoma is difficult to diagnose with the ABCD rule (Asymmetry, irregular Borders, Color variation and Diameter).

show abstract

“…Lesions with light-brown hypopigmentation areas on the periphery were 30 times more likely to be diagnosed as thin melanoma compared to lesions without this dermoscopic characteristic. 25 …”

Section: Dermoscopic Criteriamentioning

confidence: 99%

“…6.30 In a series of 940 benign melanocytic nevi, Annessi et al classified 53% as clinically benign and found 78% of histological atypicality, showing discrepancy between clinical and histopathological diagnosis. 25 In the same study, they divided the nevi into two groups: group A, consisting of nevi with a diameter between 3 and 5mm, and group B, with nevi larger than 5 mm. Comparing the two groups, a greater clinicopathological diagnostic discrepancy was observed (group A: 21% of clinical dysplasia and 68.3% of histological dysplasia, and group B: 67.4% of clinical dysplasia and 83.2% of histological dysplasia) in the group of lesions with smaller diameter (group A).…”

Section: Clinicopathological Correlationmentioning

confidence: 99%

Nevo displásico (nevo atípico)

Rezze

Duprat

2010

An. Bras. Dermatol.

View full text Add to dashboard Cite

Atypical nevum (dysplastic) is considered an important factor associated with increased risk of developing cutaneous melanoma. It is believed that atypical nevi are precursor lesions of cutaneous melanoma. They may be present in patients with multiple melanocytic nevi (atypical nevus syndrome) or isolated and in small numbers in a non-familial context. The disease usually begins at puberty and predominates in young people. It has a predilection for sun-exposed areas, especially the trunk. The major challenge in relation to atypical nevi lies in the controversy of defining its nomenclature, clinical diagnosis, dermoscopic criteria, histopathological diagnosis and molecular aspects. This review aims at bringing knowledge, facilitating comprehension and clarifying doubts about atypical nevus. Keywords: Nevi and melanomas; dermoscopy; Histology Resumo: O nevo atípico (displásico) é considerado um fator importante associado com o risco aumentado de desenvolvimento do melanoma cutâneo. Acredita-se que nevos atípicos sejam lesões precursoras do melanoma cutâneo. Podem estar presentes em pacientes com múltiplos nevos melanocíticos (síndrome do nevo atípico) ou isolados e em poucas quantidades em um contexto não familial. Aparecem, geralmente, na puberdade e prevalecem em indivíduos jovens. Têm predileção por áreas expostas ao sol, especialmente, o tronco. O grande desafio em relação ao nevo atípico reside na controvérsia em se definir sua nomenclatura, diagnóstico clínico, critérios dermatoscópicos, diagnóstico histopatológico e aspectos moleculares. Esta revisão tem por objetivo trazer o conhecimento, facilitar o entendimento e responder às questões duvidosas concernentes ao nevo atípico.

show abstract

Sensitivity, specificity, and diagnostic accuracy of three dermoscopic algorithmic methods in the diagnosis of doubtful melanocytic lesions

Cited by 116 publications

References 27 publications

The Diagnostic Accuracy of in vivo Confocal Scanning Laser Microscopy Compared to Dermoscopy of Benign and Malignant Melanocytic Lesions: A Prospective Study

The Diagnostic Accuracy of in vivo Confocal Scanning Laser Microscopy Compared to Dermoscopy of Benign and Malignant Melanocytic Lesions: A Prospective Study

Diagnostic spectrum of nodular melanoma

Nevo displásico (nevo atípico)

Contact Info

Product

Resources

About