Sensitization to Anisakis simplex s.l. in a healthy population

Moreno, Alberto; Valero, Ana; Mayorga, Cristobalina; Gómez, Belén; Torres, M.J.; Hernández, Juan González; Ortiz, Mariaestela; Maldonado, J. Lozano

doi:10.1016/j.actatropica.2005.11.007

Cited by 39 publications

(24 citation statements)

References 20 publications

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“…These studies found an incidence of specific anti-Anisakis simplex IgE antibody reactivity ranging from 6.6% to 27.5% (Del Rey Moreno et al 2006, Audicana and Kennedy 2008, Puente et al 2008. In our study, as expected, a direct association between the frequency of fish intake and anti-Anisakis IgE positivity on ELISA could be established (Table II).…”

Section: Discussionsupporting

confidence: 68%

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Cross-sectional study of serum reactivity to Anisakis simplex in healthy adults in Niterói, Brazil

Figueiredo

Vericimo

Cardoso

et al. 2013

Acta Parasitologica

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Although the incidence of anisakiasis is rising worldwide, its frequency is still unknown in Brazil. The aim of this study was to verify immunoreactivity to Anisakis simplex antigens in healthy adults and determine its possible relationship with frequency of fish consumption and allergy symptoms. A prospective cross-sectional study was carried out with 67 volunteers recruited from a military facility in Niterói, Brazil. The subjects completed a structured questionnaire and serum titers of specific anti-Anisakis IgE and IgG antibodies were measured. The association between frequency of fish intake and IgE reactivity was evaluated by Fisher's exact test. Almost all subjects (97.0%, 65/67) that consumed seafood; 64.6% (42/65) ate fish at least once weekly. Of all seafood consumers, 56.9% (37/65) reported allergy symptoms, being gut allergies most often cited (35.5%). IgE seroreactivity to Anisakis simplex was found in 20.9% of subjects (14/67), with 13.4% (9/67) reacting exclusively to somatic antigen, 3.0% (2/67) exclusively to excretory/secretory antigens and 4.5% (3/67) to both antigens. There was a significant association between frequency of fish consumption and positive serology (p = 0.019). An immunoblot assay for Anisakis antigens showed different positive bands for IgG. The direct relationship between ELISA reactivity and frequency of fish intake and absence of association with allergy symptoms suggests previous contact with Anisakis simplex antigens.

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Section: Discussionsupporting

confidence: 68%

“…This evidence is of major public health importance (Del Rey Moreno et al 2006), as subclinical sensitization is common in healthy populations with high fish and seafood intake levels (Audicana et al 2002).…”

Section: Discussionmentioning

confidence: 99%

Cross-sectional study of serum reactivity to Anisakis simplex in healthy adults in Niterói, Brazil

Figueiredo

Vericimo

Cardoso

et al. 2013

Acta Parasitologica

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“…reported seroprevalence to A. simplex of 22.1% (n = 17 out of 77 random blood donors) tested by CAP-FEIA in a healthy Spanish population (“Antequera” hospital region). Other studies in healthy populations showed seroprevalence ranging between 6.6 and 27.5%4157. Valiñas et al 42.…”

Section: Discussionmentioning

confidence: 92%

“…is relatively common in some Spanish regions46 and subclinical sensitization (i.e. Anisakis -specific IgE detection in individuals who do not show allergic manifestations) may also occur4142575859. For instance, Del Rey Moreno et al 57.…”

Section: Discussionmentioning

confidence: 99%

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Assessing the risk of an emerging zoonosis of worldwide concern: anisakiasis

Bao

Pierce

Pascual

et al. 2017

Sci Rep

152

118

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Anisakiasis is an emerging zoonosis caused by the fish parasitic nematode Anisakis. Spain appears to have the highest reported incidence in Europe and marinated anchovies are recognised as the main food vehicle. Using data on fishery landings, fish infection rates and consumption habits of the Spanish population from questionnaires, we developed a quantitative risk assessment (QRA) model for the anchovy value chain. Spaniards were estimated to consume on average 0.66 Anisakis per untreated (non-frozen) raw or marinated anchovy meal. A dose-response relationship was generated and the probability of anisakiasis was calculated to be 9.56 × 10−5 per meal, and the number of annual anisakiasis cases requiring medical attention was predicted between 7,700 and 8,320. Monte Carlo simulations estimated post-mortem migration of Anisakis from viscera to flesh increases the disease burden by >1000% whilst an education campaign to freeze anchovy before consumption may reduce cases by 80%. However, most of the questionnaire respondents who ate untreated meals knew how to prevent Anisakis infection. The QRA suggests that previously reported figures of 500 anisakiasis per year in Europe is a considerable underestimate. The QRA tool can be used by policy makers and informs industry, health professionals and consumers about this underdiagnosed zoonosis.

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Anisakid Nematodes and Anisakiasis

Lymbery

Cheah

2007

World Class Parasites

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Sensitization to Anisakis simplex s.l. in a healthy population

Cited by 39 publications

References 20 publications

Cross-sectional study of serum reactivity to Anisakis simplex in healthy adults in Niterói, Brazil

Cross-sectional study of serum reactivity to Anisakis simplex in healthy adults in Niterói, Brazil

Assessing the risk of an emerging zoonosis of worldwide concern: anisakiasis

Anisakid Nematodes and Anisakiasis

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