Sensitization to minor cat allergen components is associated with type‐2 biomarkers in young asthmatics

Tsolakis, Nikolaos; Malinovschi, Andreï; Nordvall, Lennart; Mattsson, Lars; Lidholm, Jonas; Pedroletti, Christophe; Janson, Christer; Borres, Magnus P.; Alving, Kjell

doi:10.1111/cea.13135

Cited by 21 publications

(22 citation statements)

References 40 publications

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“…To date, eight cat‐origin allergens have been identified and registered through the World Health Organization/International Union of Immunological Societies (WHO/IUIS) Allergen Nomenclature Sub‐Committee . Fel d 1, a secretoglobin, is the major cat allergen . (Table ) Although monosensitization to Fel d 1 is common, individuals sensitized to the cat allergens Fel d 2 (an albumin allergen) and Fel d 4 (a lipocalin allergen) are usually also sensitized to Fel d 1 .…”

Section: Fel D1 the Major Cat Allergenmentioning

confidence: 99%

“…2,[10][11][12] Fel d 1, a secretoglobin, is the major cat allergen. 2,[5][6][7][8][9]13 (Table 1) Although monosensitization to Fel d 1 is common, individuals sensitized to the cat allergens Fel d 2 (an albumin allergen) and Fel d 4 (a lipocalin allergen) are usually also sensitized to Fel d 1. 3 Fel d 1 is a sufficiently dominant allergen that IgE sensitization to Fel d 1 is equivalent to cat extract in predicting cat allergy.…”

Section: Fel D1 the Ma Jor C At Allerg Enmentioning

confidence: 99%

“…Allergies to cats are the most common mammalian‐origin allergy in humans and affect approximately 1 in 5 adults worldwide . Fel d 1 is the major cat allergen, accounting for up to 96% of human allergic sensitization to cats and 60%‐90% of the overall antigenicity of cats and cat dander …”

Section: Introductionmentioning

confidence: 99%

“…4,5 Fel d 1 is the major cat allergen, accounting for up to 96% of human allergic sensitization to cats and 60%-90% of the overall antigenicity of cats and cat dander. 2,[5][6][7][8][9] Traditional care pathways for cat allergies focus on treating patients who are exposed to cat allergens. The following review expands on information presented during a sponsored symposium at the European Academy of Allergy and Clinical Immunology (EAACI) Annual Congress on June 4, 2019, in Lisbon, Portugal.…”

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confidence: 99%

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Keep the cat, change the care pathway: A transformational approach to managing Fel d 1, the major cat allergen

Satyaraj¹,

Wedner

Bousquet

2019

Allergy

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Background Allergies to cats are the most common animal‐origin allergy, and affect approximately 1 in 5 adults worldwide. The prevalence of allergy to furry animals has been increasing, and allergy to cats is a major risk factor for the development of asthma and rhinitis. The diagnosis of cat allergy is now well established. The exact significance of component‐resolved diagnosis in the diagnosis of cat allergy remains to be fully understood. Allergen avoidance is effective but often has a psychologic impact. Allergen immunotherapy is not well demonstrated. There is a need for innovative approaches to better manage cat allergens. Next‐generation care pathways for asthma and rhinitis will define the place of cat allergen avoidance. Methods and Results This manuscript, based on content presented at the European Academy of Allergy and Clinical Immunology Congress 2019, provides information on the prevalence and impact of cat allergies and the molecular biology of Fel d 1, the major cat allergen. Discussion The authors present the scientific basis of a novel care pathway that utilizes anti‐Fel d 1 IgY antibodies to safely and effectively neutralize Fel d 1 after its production by the cat but before human exposure. Conclusion Efficacy of a feline diet with an egg product ingredient containing anti‐Fel d 1 IgY antibodies was demonstrated in vitro, ex vivo, and in vivo, and further validated by a pilot exposure study involving cat‐allergic human participants.

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Section: Fel D1 the Major Cat Allergenmentioning

confidence: 99%

Section: Fel D1 the Ma Jor C At Allerg Enmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Keep the cat, change the care pathway: A transformational approach to managing Fel d 1, the major cat allergen

Satyaraj¹,

Wedner

Bousquet

2019

Allergy

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“…Novel data on sensitization patterns have emerged from recent studies that have used component-resolved diagnostics to increase knowledge on sensitization profiles and cross-reactivity [28, 49, 54, 55]. Numerous studies have demonstrated that sensitization, especially high pet-specific IgE levels and co-sensitization, are strongly associated with the prevalence, severity and persistence of asthma [5, 26, 49, 54, 56–58]. Among pet-sensitive individuals, increased exposure levels can have considerable public health effects.…”

Section: Bedroom Allergen Exposuresmentioning

confidence: 99%

Bedroom Allergen Exposure Beyond House Dust Mites

Salo

Cohn²,

Zeldin

2018

Curr Allergy Asthma Rep

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Purpose of the review: The review provides insight into recent findings on bedroom allergen exposures, primarily focusing on pet, pest and fungal exposures. Recent findings: Large-scale studies and improved exposure assessment technologies, including measurement of airborne allergens and of multiple allergens simultaneously, has extended our understanding of indoor allergen exposures and their impact on allergic disease. Practical, streamlined methods for exposure reduction have shown promise in some settings, and potential protective effects of early-life exposures have been further elucidated through the investigation of specific bacterial taxa. Advances in molecular allergology have yielded novel data on sensitization profiles and cross-reactivity. Summary: The role of indoor allergen exposures in allergic disease is complex and remains incompletely understood. Advancing our knowledge of various co-exposures, including the environmental and host microbiome, that interact with allergens in early life will be crucial for the development of efficacious interventions to reduce the substantial economic and social burden of allergic diseases including asthma.

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Sensitization patterns to cat molecular allergens in subjects with allergic sensitization to cat dander

Özuygur Ermis,

Norouzi,

Borres

et al. 2023

Clinical & Translational All

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BackgroundThe use of molecular allergology has increasingly become common in the diagnosis and management of allergic diseases. However, there is still a lack of data on cat molecular allergens in adults. Therefore, we aimed to uncover the sensitization patterns to cat molecular allergens.MethodsParticipants were recruited from the West Asthma Sweden Study, a population‐based study enriched with asthma subjects aged 16–75 years. Of 1872, 361 individuals were positive for cat dander immunoglobulin E and were further analysed for cat molecular allergens (Fel d 1/2/4/7). Sensitization patterns were classified as monosensitization, polysensitization, and concomitant sensitization, and were related to demographic and clinical measurements.ResultsAmong cat‐sensitized subjects, 84.2% were sensitized to secretoglobin, while 42.4% were sensitized to lipocalins. Nearly half of the subjects were monosensitized to Fel d 1. Polysensitization was observed in 20.2%, and concomitant sensitization to protein families was seen in 7.2%. Asthma prevalence, cat exposure, and rural living were associated with poly‐ and concomitant sensitization to protein families. Concomitant sensitization to single allergens was more common in those with asthma than in those without, while concomitant sensitization to both Fel d 1 and Fel d 4 was the most common pattern in individuals with asthma. Sensitization patterns also differed according to cat ownership and the degree of urbanization.ConclusionSensitization to molecular allergens was observed in 90.9% of cat‐sensitized subjects and showed variations across participants' background characteristics and the presence of asthma. Identification of sensitization patterns to cat allergens might provide better characterization of cat‐allergic subjects.

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Sensitization to minor cat allergen components is associated with type‐2 biomarkers in young asthmatics

Abstract: We suggest that measurement of IgE to minor cat allergen components may be useful when investigating asthma morbidity in cat allergic subjects.

Cited by 21 publications

References 40 publications

Keep the cat, change the care pathway: A transformational approach to managing Fel d 1, the major cat allergen

Keep the cat, change the care pathway: A transformational approach to managing Fel d 1, the major cat allergen

Bedroom Allergen Exposure Beyond House Dust Mites

Sensitization patterns to cat molecular allergens in subjects with allergic sensitization to cat dander

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